DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITPR1 and Itpr

DIOPT Version :9

Sequence 1:	XP_011531983.1	Gene:	ITPR1 / 3708	HGNCID:	6180	Length:	2759	Species:	Homo sapiens
Sequence 2:	NP_730941.1	Gene:	Itpr / 40664	FlyBaseID:	FBgn0010051	Length:	2837	Species:	Drosophila melanogaster

Alignment Length:	2926	Identity:	1659/2926 - (56%)
Similarity:	2049/2926 - (70%)	Gaps:	281/2926 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSDKM---SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCP 62
            |.|.:   :||||:|||.|||||||..||:|||||||||.||.||.|||:.|||||||||.|:||
  Fly     1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65

Human    63 MNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGN-VIQLLHL 126
            |||||||||||||||..|:|.||..||.:|||||::|||||||||:|||||.||||. |:|||||
  Fly    66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130

Human   127 KSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQ 191
            |||||||||||||:|||||||||.||..|||||||||:||||||||||.||:||||:|:||||.|
  Fly   131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195

Human   192 P-LH-ASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254
            . || |::::|.|||||.|||.:|.:|||||.|||:..:|::.||||||||||||||||||||.|
  Fly   196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260

Human   255 EHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVD 319
            |::|:.|||||||||.|||:|||||||||:||||||.||||||.||||:||||||||||||||.:
  Fly   261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325

Human   320 PDFEEECLEFQPSVDPD---QDASR----------SRLRNAQEKMVYSLVSVPEGNDISSIFELD 371
            .|.....:....:...|   .|.|:          |.:.:..:...|.|||||...||:|:|.||
  Fly   326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLD 390

Human   372 PTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVS 436
            .||:...|||||::|||||:|:|:|||||:|:||||.:::||||..:..||:||||||||::|||
  Fly   391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455

Human   437 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTN--SGQDVLEVVF 499
            |.|||||||||||.|||.::..||:.|:|:.||||::..||:|:|||:.|..|  :....||...
  Fly   456 PVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTI 520

Human   500 SKPNRERQKLMREQNILKQIFKLLQAPFTD--CGDGPMLRLEELGDQRHAPFRHICRLCYRVLRH 562
            ..|.|:||||:|||.||||:||:||.||..  .||||.|||:||.|.:::|:::|.|||||:||.
  Fly   521 KNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRL 585

Human   563 SQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNR- 626
            ||||||||||||||.||.||||||||:||||||||||||||||||||||||||:|||.|||||.
  Fly   586 SQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMH 650

Human   627 --EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGEN--- 686
              :.||||||||||||..|:|.||||||||:||:..|.||||||::...|        ||..
  Fly   651 NWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALR--------TGSGPVR 707

Human   687 --------------ALEAGEDEE-------------------------------EVWLFWRDSNK 706
                          |.:||:||:                               |:.|.|   ..
  Fly   708 CYKGNSEDVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TG 769

Human   707 EIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSD 771
            :..|:|:.:||  :.:|.:.:..:|:|||:|||||:.|||:|||||:||:|.:||:||||:||||
  Fly   770 QPTSRSMADLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSD 832

Human   772 ENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKE---- 832
            |.:||:|||||||||||:||||||||.|||||||||||||||:::|.|||......|:.|:
  Fly   833 ETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRA 897

Human   833 RFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILD 897
            :|..|:.|||.||.:|..:.:.|:|:|:||||||||.|||:|||||||:|||||||||.||:|||
  Fly   898 KFNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILD 962

Human   898 CVHVTTIFPISKMAKGE---------ENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLP 953
            ||        |..:.||         |.:.|.:.|    ..|:|||..:..:||.:.|...|
  Fly   963 CV--------SDTSSGEFASTDIDSVEEETNAEAE----GGVLRSIGDINTVMTSLALGSVG--- 1012

Human   954 MTPMAAAPEGNVKQ----AEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDES 1014
              ...|||..:::|    ::..||..:||||||||||||||||:|||||||||||.|||||||||
  Fly  1013 --QAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDES 1075

Human  1015 N---SQTSETSSGNSSQEGPSNVPGA-----------------------------LDFEHIEEQA 1047
            .   |..|..:|...||:.....||:                             :|.|.|..||
  Fly  1076 EVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQA 1140

Human  1048 EGIFGGSEENTP-LDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQ 1111
            ||||.....:.. ||||..||||||||||||.||||.|||||||.||||||||||||||||:|||
  Fly  1141 EGIFDCERSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQ 1205

Human  1112 LLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGN---NKPQ 1173
            |||:..||::|||||.|||.||..||||||||||.:..||.  ||:.......:.|.|   ::.|
  Fly  1206 LLVSDSDVESYKQIKSDLDILRQSVEKSELWVYKAKATDEL--GATDAGGDAVSLEYNAALSQEQ 1268

Human  1174 KHESTSSYNYRVVKEILIRLSKLCVQES--ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAE 1236
            ::|      ||.|||||||::|.||..|  .||.|.||.:||||||:|.|.|||:|||.||::.:
  Fly  1269 RNE------YRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKD 1327

Human  1237 DTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERV 1301
            |..|:|:|.||||||||||.||||||.|||.|::||||||||||.|:..||.:|..||:|:.::|
  Fly  1328 DELMKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKV 1392

Human  1302 VQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQ 1366
            |||||||||.|||:|.|::||||:|:||.:||::||||||.||:||||||||||||:.||...:|
  Fly  1393 VQHFVHCIEIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQ 1457

Human  1367 MMRSERDRMD---ENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEV 1428
            ||:.:..||:   ::|||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:|||
  Fly  1458 MMQQQMLRMEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1522

Human  1429 KIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFE-NFLVDICRACNNTSDRKHADSILEKYVTEIV 1492
            |.||::||||||:||||||||||.|.|||.||| :|||||.:...|.:  ..::..|:.||...|
  Fly  1523 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPA--AASNKTLQAYVLNGV 1585

Human  1493 MSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRA 1557
            .:::.:||:|||||||..:|:||.:||||||...|:..|.||....:.:||:|||.|::.||.|:
  Fly  1586 TNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRS 1650

Human  1558 IAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAAS--RDYRNIIERLQDIVSAL 1620
            ||:|.:|:.||..:..|:..:.::|. .|.|:::. .:.::..|||  |..|:|||.||||||.|
  Fly  1651 IALPPELEQQVATMSSKTAMLTRQTT-KWLLASKQ-PKYEAQQAASLMRWDRSIIEGLQDIVSLL 1713

Human  1621 EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVL 1685
            ||:|:|:|:||||:|||:|:|.|||||..|:||::|||||||.||||||::||||.||::|:|||
  Fly  1714 EDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVL 1778

Human  1686 QTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENATEQELEPSPPLRQLEDHKRGEALRQVLV 1750
            :||||||..|..||||                                        |:||||.|:
  Fly  1779 RTLREMMAIDVNYGEK----------------------------------------GDALRQTLL 1803

Human  1751 NRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGG-GGGGSGSSSMSRGEMSLAEVQCHLDKEGAS 1814
            .||:.........|........||.  .|.|... ...|.|:..:.|...:|.|:|.|||:||||
  Fly  1804 LRYFQTKSTPRLPEDEVPLLAAPLM--DPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGAS 1866

Human  1815 NLVIDLIM-NASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQ 1878
            :||::|:: :..|..:|.|::.|.||||||||..||...|.:...|..::.|||||:::||.|||
  Fly  1867 DLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQ 1931

Human  1879 EIKATVTVNTSDLGNK----KKDDEVDRDAPSRKKA-KEPTTQITEEVRDQLLEASAATRKAFTT 1938
            |||:||||||:|:..|    |:|..::.|..:||.. |.....||||::.:|..|..||.:|:..
  Fly  1932 EIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGN 1996

Human  1939 FRREADPDDHYQPGEGTQATA-------------DKAKDDL----EMSAVITIMQPILRFLQLLC 1986
            .|       :...||.:.|.:             :|.||..    ::|..:.:||||||||||||
  Fly  1997 AR-------NIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLC 2054

Human  1987 ENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTE 2051
            ||||.|:||.||.||||||.|||.|||.||||||||||||||||||||||.||||||||||:|||
  Fly  2055 ENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTE 2119

Human  2052 YCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSE 2116
            ||||||||||||||||||||:|||||||||:|||||:.|||||||||||||||||||||||.|||
  Fly  2120 YCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSE 2184

Human  2117 NAERILYNMRPKELVEVIKKAYMQGEV--EFEDGE------NGEDGAASPRNVGHNIYILAHQLA 2173
            |||||||||.||:||||..|||.|.|:  |.:||:      :.:|...|||.||||||||.||||
  Fly  2185 NAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLA 2249

Human  2174 RHNKELQSMLKPGGQVDG-------DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKE 2231
            :|||||..:||.......       .:||.:||.|||||||||.|||:||||||:|.|||:||.:
  Fly  2250 QHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTD 2314

Human  2232 SKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLM 2296
            :|::|..|.|||:||||:.|||.::|::||||.||||||:||:|:|.:..||.||:|.||..|::
  Fly  2315 TKIKILNTAERDDQGSKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVI 2379

Human  2297 NLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQP 2361
            |::|||||||... ...|..|.|.|.|...:.||.||:|||:..|||..|.|.|||.||.:|.:.
  Fly  2380 NMIVAFFYPFDNT-VPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPES 2443

Human  2362 TLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLL 2426
            ||.|||...|..|.:.::|.:||.||..:....::.|.:.|||.:|:..|..||..|.|||||||
  Fly  2444 TLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLL 2508

Human  2427 FDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPE 2491
            ||:|||||||:|||:|||||||||:|||||||||||||||:||:||||||::.||....:.|.|.
  Fly  2509 FDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPP 2573

Human  2492 TGESLASEFLFSDVCRVESGENCSSP-------APREELVPAEETEQDKEHTCETLLMCIVTVLS 2549
            :.....|..:        ||::||:|       |.:|...|:....:.||.:|::|:|||||.|:
  Fly  2574 SVPLTLSVPV--------SGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLN 2630

Human  2550 HGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEE 2614
            .|||:|||:||:||.||.:|.||.|||||||||||:|||||||||||||||||||||||||:||.
  Fly  2631 QGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEA 2695

Human  2615 ILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKER 2679
            |||||||||.|.|..||||||:||||||.||||||||.|||||||||.||:|||||||..|:|..
  Fly  2696 ILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAG 2760

Human  2680 NLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGL 2744
            .|:||||:|||||.:.|::|||.|||::|.:|..|..|:.|||.||.||||.||||||||||:||
  Fly  2761 ILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGL 2825

Human  2745 L 2745
            |
  Fly  2826 L 2826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITPR1	XP_011531983.1	Ins145_P3_rec	4..225	CDD:285871	169/226 (75%)
		MIR	231..287	CDD:197746	45/55 (82%)
		MIR	232..433	CDD:280906	129/213 (61%)
		MIR	294..>321	CDD:197746	22/26 (85%)
		RYDR_ITPR	476..665	CDD:279676	132/195 (68%)
		RYDR_ITPR	1209..1340	CDD:279676	85/130 (65%)
		RIH_assoc	1974..2079	CDD:285630	93/104 (89%)
		Ion_trans	2351..2610	CDD:278921	149/265 (56%)
Itpr	NP_730941.1	Ins145_P3_rec	7..231	CDD:285871	169/223 (76%)
		MIR	237..293	CDD:197746	45/55 (82%)
		MIR	238..452	CDD:280906	129/213 (61%)
		RYDR_ITPR	495..691	CDD:279676	132/195 (68%)
		RYDR_ITPR	1294..1413	CDD:279676	77/118 (65%)
		RIH_assoc	2042..2147	CDD:285630	93/104 (89%)
		Ion_trans	2433..2691	CDD:278921	149/265 (56%)
		Sec2p	<2782..2819	CDD:283965	22/36 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	484	1.000	Domainoid score	I400
eggNOG	1	0.900	-	-		E1_KOG3533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1673
Inparanoid	1	1.050	2952	1.000	Inparanoid score	I18
Isobase	1	0.950	-	0	Normalized mean entropy	S3971
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D58374at33208
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		otm41564
orthoMCL	1	0.900	-	-		OOG6_102308
Panther	1	1.100	-	-	LDO	PTHR13715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3112
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820