DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITPR1 and itr-1

DIOPT Version :9

Sequence 1:XP_011531983.1 Gene:ITPR1 / 3708 HGNCID:6180 Length:2759 Species:Homo sapiens
Sequence 2:NP_001023170.1 Gene:itr-1 / 177546 WormBaseID:WBGene00002173 Length:2892 Species:Caenorhabditis elegans


Alignment Length:3019 Identity:1147/3019 - (37%)
Similarity:1650/3019 - (54%) Gaps:506/3019 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQ 69
            ||||||.|||.|.|:|    ||:||||||||||:|:.:.|...:|||||||||||:||:|||:||
 Worm    83 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQ 147

Human    70 KQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYL 132
            |..|...|  ...:|..|..|:|||..|||.|:::||:|.:|.||.|||||:::||||:|||||:
 Worm   148 KHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYI 212

Human   133 TVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNP-----VNAG-- 190
            ||.|..||..|:|||:|.||.||||||||.|:|.||..:|||:|..|:|:.|.|     ..||  
 Worm   213 TVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHV 277

Human   191 -QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254
             ..||.||..|:|:....|||.:|..|.|::.:|:.:.:|:.:.:|.|||||||||:|:.|||.|
 Worm   278 KSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLD 342

Human   255 EHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLA 315
            ...|:..    ||||.|.|.||..||||:|||||:|||.:..|||...||..:|||||||..||:
 Worm   343 TIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 407

Human   316 AEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVP-----EG-------------- 361
            ||                 |.|...:..:...:..::||..:.|     :|              
 Worm   408 AE-----------------PSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQ 455

Human   362 -----------------NDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHST------N 403
                             .|.:.:|:|||:|....:..|||.|||||.|..::.|||:|      |
 Worm   456 NIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQN 520

Human   404 IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQN 468
            :....:.||. .:|:.....:.|||.||::||:|.|||||||||||.|.|.:....::.|.:...
 Worm   521 LHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISK 584

Human   469 ER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPF----- 527
            |. .|.|:||.|.:.|||..::...|.|::....|:|:||||:|||.:|.|:|.||:|||     
 Worm   585 ESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQG 649

Human   528 -TDCGDGPMLRL-EELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVL 590
             |:.  ||:|.. .||.|.|:..|:.:.:|||.:|::||..||||||::|::||.:|:|||:|::
 Worm   650 TTEL--GPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLM 712

Human   591 AEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKA 655
            ||||:||:||||.|||||::....::.||.|||.||:.:|||||:||||...::....|||||.:
 Worm   713 AEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS 777

Human   656 VLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
            ||:..:.||.::||::             :..:|.|         |        :.:.|:|. |.
 Worm   778 VLSSKHRDIFMDTKII-------------DGEIEVG---------W--------APNFRKLV-DI 811

Human   721 KEGQK---EDRDVLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENL 774
            .||.|   :|.:.|.|||:||:|.::||.::|||||:        .||.||..:|:|:||||..|
 Worm   812 AEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRL 876

Human   775 PYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKER 833
            |||||.||.|||||:||.|.  ..::.:::||||..||..:.:..|:|      |..|:..|.|.
 Worm   877 PYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEG 939

Human   834 FA-QTMEFVEEYLRDVVCQRFPFSDKEK-----NKLTFEVVNLARNLIYFGFYNFSDLLRLTKIL 892
            .| :.:..||.||..:..|    |.:|:     :|||:|:||||:.|..|.||:|:|||:||:.|
 Worm   940 IAHKVLATVETYLMGLRNQ----SMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNL 1000

Human   893 LAILDCVHVTTIFPISKMAKGEENKGNNDVEKLKSS-NVMRSIHGVGELMTQVVLRGGGFLPMTP 956
            |||::                 |......|...::. |.:|:       |::.::|||.......
 Worm  1001 LAIIN-----------------EGPATEQVPSHRAMVNAIRN-------MSKSMMRGGNKENSKD 1041

Human   957 MAAAPEGNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREF--DESNSQT 1018
            :|..|....::|...||. .:.:.|||.:.|||||:::||.||||:..|..||..|  ||..|..
 Worm  1042 LAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLM 1106

Human  1019 SETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYP 1083
            ...|               ::.....|..:.|:..|...  |.||...|:..|.:||.:||.|||
 Worm  1107 HSAS---------------INERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYP 1154

Human  1084 PLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG 1148
            ||.|.||::.||||:|.||:|:..|||||||::.||:||:||.:||..|:::.|||||||:..:.
 Worm  1155 PLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRH 1219

Human  1149 ---PDETMDGASGENEHKKTEEGNNKPQKHESTSSYN---------------------------- 1182
               ..:.:|......||...:.....|:..:|..|..                            
 Worm  1220 HSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKD 1284

Human  1183 --------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLEL 1227
                                |.:::::|:||:.:|.::...  |.....|:||:||..:.||||.
 Worm  1285 DRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRVYEVVLEF 1347

Human  1228 LQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINL-------FLNPGILEAV-TMQ 1284
            :.:|::|..|..|.:::.|:||||::||..|::||:.|:|.|:.       .|....:|.| |:.
 Worm  1348 ISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLV 1412

Human  1285 HIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGE 1349
            .||.||.:|.|.:.|.::.|.|..||.:.||..:::.||.:|....|.|:..|:.|..|:..:.:
 Worm  1413 AIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1477

Human  1350 DVLVFYNDRASFQTLIQMMRSERD----RMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLL 1410
            :|...|.|.|||:.|..||:.|::    ..|....|.|||.||.|||:||.|||..||:||.|.:
 Worm  1478 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQI 1542

Human  1411 PLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTS 1475
            |:|.||||||.:.|:.|||..|:..|.|||:||:.|||:.|.:.::..:..|.|.|| |:.....
 Worm  1543 PMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEK 1606

Human  1476 DRKHADSILEKYVTEIVMSIVTTFFSSPFS-------DQSTTLQTRQPVFVQLL---QGVFRVYH 1530
            ......:.||.|:...|..::..||.:|:|       |.....:|...|.::|.   :|..|...
 Worm  1607 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSK 1671

Human  1531 C--NWLMPSQKASVESCIRVLSDVAKSRAIAIPVDL-DSQVNNLFLKSHSIVQKTAMNWRLSARN 1592
            .  ||.      .|..||:.|:..|:...|.:|..| ..|::.    ..|:.||    |:.:|.:
 Worm  1672 SSRNWY------RVAECIKRLTKWAEEHNITLPATLAGPQMSG----QTSVRQK----WQQAASS 1722

Human  1593 AA---------RRDSVLAASRDY-----------RNIIERLQDIVSALEDRLRPLVQAELSVLVD 1637
            |.         |::::....|.|           .|::.....::...:..|.||..||.||||:
 Worm  1723 AKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 1787

Human  1638 VLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKL 1702
            |||.|||||||.:..|.:|..||.:.|||:|.|.|::..::.||.:|||||.:|.          
 Worm  1788 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMC---------- 1842

Human  1703 ISIDELDNAELPPAPDSENATEQELEPSPPLRQLEDHKRGEALRQVLVNRYYGNVR----PSGRR 1763
                              :.|:|:|.           .:|:.|||:|:.||:|:..    |..|:
 Worm  1843 ------------------DCTKQQLT-----------HQGQQLRQLLLQRYFGHHNNHHPPLDRQ 1878

Human  1764 ESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDR 1828
            :|..    |.:......|.        ..:.|: |..|..:||.|:..|||:||.|:|:...|..
 Worm  1879 QSKI----GEVIEAVKEKK--------EETWSQ-ERDLYAIQCKLNDAGASDLVTDIIIMEPSRE 1930

Human  1829 VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGN 1893
            :|.::|.||.|||..||..:||||:.|:.:....|.|||....|::.||..:|:.: ::.||  :
 Worm  1931 IFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSD--S 1992

Human  1894 KKKDDEVDRDAPSRKKAKEPTTQITE-----------EVRDQLLEASAATRKAFTTFRREADPD- 1946
            |.|   |...|...:::....|.:.:           ||..|:...|.:.....:.....:.|| 
 Worm  1993 KPK---VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDL 2054

Human  1947 DHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCE 2011
            ..||         |:.|....:...:.:::||||.|||||||||..||||||.|:::||:|||.|
 Worm  2055 APYQ---------DEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSE 2110

Human  2012 TLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIIT 2076
            ||.|||.:||||.|.||:.| .|.|.|.:||.|||.:|||:||||||||||.:|..| ||::||.
 Worm  2111 TLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIII 2173

Human  2077 ALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMR-----PKELVEVIKK 2136
            :|:||:|.||....|:|.||:|:.||||||||||||||.|||.|:|.||.     ||:||..||:
 Worm  2174 SLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQ 2238

Human  2137 AY------------------MQGEVE--------------------------------------F 2145
            ||                  .|.|.:                                      .
 Worm  2239 AYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSL 2303

Human  2146 EDGENGED-GAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIE 2206
            :|..|.:| .:..||.|||||||||||||.|:.||:..|....:...|   |||.:|.:.|||||
 Worm  2304 DDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIE 2368

Human  2207 IVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRA 2271
            |||.|||:|::|||:..||.:|||::|..:|..||||.||||:.:||...|.:::||.||:||:.
 Worm  2369 IVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 2433

Human  2272 QPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLL-------WTAMLIS 2329
            :..|.|||..:..|:.:||:.|.::|.|||.:||        |..|.:..:       |.|:..|
 Worm  2434 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP--------LPEHSNSSISLGNLYSWFAVFSS 2490

Human  2330 LAIVIALPKPHGIR-----------ALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVG 2383
            ..:.      |.:|           .::||....|:.|:|:..||::.|...:.|||:.:::||.
 Worm  2491 FLLA------HYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVS 2549

Human  2384 NCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGR 2448
            |.|...|....::......|.|:||.||.:||.||...|.:||||:::.||||.|||.|||||.:
 Worm  2550 NKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQ 2614

Human  2449 SIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGEN 2513
            ||:.|.:|||||:|.|||:|:|:|:.||.||||.:.|:::      :..|..:.|:.|   ..|.
 Worm  2615 SIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC---PSEG 2670

Human  2514 CSSPAPREELVPAEETEQDKE---HTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAAR 2575
            |..      |.|:|:.:.|.|   .:||||.|||:.....|||:|||:|||||.|:..|.:|..|
 Worm  2671 CPG------LQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWR 2729

Human  2576 VIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEH 2640
            |.||:.||.::|:||||||||||||||.|||:||.:||:|||..||||||:|.:|||::||||.|
 Worm  2730 VAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETH 2794

Human  2641 IKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELR 2705
            .:.|||:||||.:||::::||.||:||||||||:.:|:|||||||||:|:||..|:.:.:|:|::
 Worm  2795 RETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVK 2859

Human  2706 NLQEKLESTMKLVTNLSGQLSELKDQMTE 2734
            .::::|...|.|:..:..|..|.:..|.:
 Worm  2860 QMKDQLLQMMTLMREIISQNEESRAFMEQ 2888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITPR1XP_011531983.1 Ins145_P3_rec 4..225 CDD:285871 124/229 (54%)
MIR 231..287 CDD:197746 33/59 (56%)
MIR 232..433 CDD:280906 86/246 (35%)
MIR 294..>321 CDD:197746 15/26 (58%)
RYDR_ITPR 476..665 CDD:279676 93/195 (48%)
RYDR_ITPR 1209..1340 CDD:279676 49/138 (36%)
RIH_assoc 1974..2079 CDD:285630 66/104 (63%)
Ion_trans 2351..2610 CDD:278921 119/261 (46%)
itr-1NP_001023170.1 Ins145_P3_rec 78..312 CDD:285871 123/228 (54%)
MIR 320..548 CDD:280906 85/245 (35%)
RYDR_ITPR 593..787 CDD:279676 93/195 (48%)
RYDR_ITPR 1326..1473 CDD:279676 52/146 (36%)
RIH_assoc 2073..2176 CDD:285630 66/104 (63%)
GPI2 <2447..2539 CDD:283969 25/105 (24%)
glyco_rpt_poly 2452..>2640 CDD:275163 73/201 (36%)
PelG 2507..>2636 CDD:294999 56/128 (44%)
Ion_trans <2570..2764 CDD:278921 104/208 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I1289
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1673
Inparanoid 1 1.050 1707 1.000 Inparanoid score I26
Isobase 1 0.950 - 0 Normalized mean entropy S3971
OMA 1 1.010 - - QHG58623
OrthoDB 1 1.010 - - D58374at33208
OrthoFinder 1 1.000 - - FOG0001660
OrthoInspector 1 1.000 - - otm14885
orthoMCL 1 0.900 - - OOG6_102308
Panther 1 1.100 - - LDO PTHR13715
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3112
SonicParanoid 1 1.000 - - X1057
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.960

Return to query results.
Submit another query.