DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITPR1 and itpr1b

DIOPT Version :9

Sequence 1:	XP_011531983.1	Gene:	ITPR1 / 3708	HGNCID:	6180	Length:	2759	Species:	Homo sapiens
Sequence 2:	XP_021335554.1	Gene:	itpr1b / 100149388	ZFINID:	ZDB-GENE-070604-2	Length:	2767	Species:	Danio rerio

Alignment Length:	2794	Identity:	2385/2794 - (85%)
Similarity:	2551/2794 - (91%)	Gaps:	62/2794 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNR 65
            ||||||||||||||||||||||||||||||||||||||||||:|||||||||||||.|:||||||
Zfish     1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPESGDLNNPPKKFRDCQFRLCPMNR 65

Human    66 YSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNK 130
            ||||||||||||||.|||||.||||||||||||||||||:|||||||||||||||||||||||||
Zfish    66 YSAQKQFWKAAKPGGNSTTDTVLLNKLHHAADLEKKQNESENRKLLGTVIQYGNVIQLLHLKSNK 130

Human   131 YLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHA 195
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Zfish   131 YLTVNKRLPALLEKNAMRVTLDSAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHA 195

Human   196 SSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQ 260
            |||||||||||||||||||||||||||||||||||:.||||||||||||||||||||||||||||
Zfish   196 SSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKEAILKGGDVVRLFHAEQEKFLTCDEHRKKQ 260

Human   261 HVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAA---EVDPDF 322
            |||||||||||||||||||||||:||||||||||||||||||||||||||||||||   ||:||:
Zfish   261 HVFLRTTGRQSATSATSSKALWEIEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVSEVNPDY 325

Human   323 EEECLEFQPSV----------DPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRG 377
            |||..|.:.||          |.:.:|.|:|||...||::|||||||:|||||||||||||||||
Zfish   326 EEESQESRSSVADFSPFNFQLDSEHEALRARLRTPNEKVMYSLVSVPDGNDISSIFELDPTTLRG 390

Human   378 GDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRD 442
            ||||||||||||||||||||||||||.||||||||||||:||||.|||||||||||||.||||||
Zfish   391 GDSLVPRNSYVRLRHLCTNTWVHSTNNPIDKEEEKPVMLRIGTSAVKEDKEAFAIVPVPPAEVRD 455

Human   443 LDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQ 507
            |||||||||||.|||||||||||||||||.|||||||||:||....|:||||||::.:|||||||
Zfish   456 LDFANDASKVLASIAGKLEKGTITQNERRFVTKLLEDLVFFVVDIPNNGQDVLEIMVNKPNRERQ 520

Human   508 KLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQE 572
            ||||||||||||||||||||||.|||||||||||.||||||||||||||||||||||||||||||
Zfish   521 KLMREQNILKQIFKLLQAPFTDSGDGPMLRLEELNDQRHAPFRHICRLCYRVLRHSQQDYRKNQE 585

Human   573 YIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDL 637
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   586 YIAKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDL 650

Human   638 CVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWR 702
            ||||||||||||||||.|||||.||||||||||||||||.|    :||..:|:..|||||||||:
Zfish   651 CVSMNKSIPVTQELICNAVLNPANADILIETKLVLSRFEVE----SGEGPMESEIDEEEVWLFWK 711

Human   703 DSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILR 767
            :||||::|||:||||||||||||:|:||:||||||||||||||||||||||.:||||||||||||
Zfish   712 NSNKEVKSKSIRELAQDAKEGQKDDQDVISYYRYQLNLFARMCLDRQYLAIEKISGQLDVDLILR 776

Human   768 CMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKE 832
            |||||:||||||||||||||||||||||||||.|||||||||||||:|||||||:.|.|:|||||
Zfish   777 CMSDEDLPYDLRASFCRLMLHMHVDRDPQEQVMPVKYARLWSEIPSKIAIDDYDNDGTSRDEIKE 841

Human   833 RFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILD 897
            |||.||:|||.||||||.|..||||||||||||||||||||||||||||||||||||||||||||
Zfish   842 RFALTMDFVENYLRDVVLQNVPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILD 906

Human   898 CVHVTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 962
            ||||:||:||:||.||:|:         ||||||:|||||||||||||||||||||.|| ...|:
Zfish   907 CVHVSTIYPINKMEKGDES---------KSSNVMKSIHGVGELMTQVVLRGGGFLPTTP-TTPPD 961

Human   963 GNV--KQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGN 1025
            |:|  .|.|||||||:|||||||||||||||||||||||||||||||||||||||:||....:.|
Zfish   962 GDVVKTQTEPEKEDILVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNTQTDTAPAPN 1026

Human  1026 SSQEGPSNVPG--ALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSG 1088
            :  :||:::|.  |||||:||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1027 A--DGPNSIPNIPALDFENIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSG 1089

Human  1089 ALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETM 1153
            ||.|||||||||||||.|||||||||||||||||||||.|||||||.||||||||||.|| ||.|
Zfish  1090 ALHLLFRHFSQRQEVLMAFKQVQLLVTSQDVDNYKQIKSDLDQLRSNVEKSELWVYKRQG-DEGM 1153

Human  1154 DGASG---ENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLL 1215
            ||..|   |::|||..:..:..:|.:...|.|||.|||||:|||||||||..|.:||:|||||||
Zfish  1154 DGGDGLPAESDHKKKRDSGSDKKKTDGNGSDNYRDVKEILLRLSKLCVQEGPSGKKSKKQQQRLL 1218

Human  1216 RNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEA 1280
            ||||||:||||||||||||.||.:|||||:|||||||||||||||||||||||||||||||||||
Zfish  1219 RNMGAHSVVLELLQIPYEKGEDVRMQEIMKLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEA 1283

Human  1281 VTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELV 1345
            :|||||||||||||||:|||||||||||||||||:|||:||||||||||.||||||||:||||||
Zfish  1284 ITMQHIFMNNFQLCSEMNERVVQHFVHCIETHGRHVQYLKFLQTIVKAENKFIKKCQDIVMAELV 1348

Human  1346 NSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLL 1410
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Zfish  1349 NSGEDVLVFYNDRASFQTLVQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLL 1413

Human  1411 PLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTS 1475
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||.|||||
Zfish  1414 PLDDIVRVVTHKDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRVCNNTS 1478

Human  1476 DRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKA 1540
            ||||||:.||.||||.||||||||||||||||||:|||||||||||||||||||||:||:||||.
Zfish  1479 DRKHADTTLESYVTETVMSIVTTFFSSPFSDQSTSLQTRQPVFVQLLQGVFRVYHCSWLLPSQKG 1543

Human  1541 SVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRD 1605
            ||||||:|||||||||||||||||||||||||:||:::||||.:|||||||||:||||.|.||:|
Zfish  1544 SVESCIKVLSDVAKSRAIAIPVDLDSQVNNLFVKSNNVVQKTILNWRLSARNASRRDSTLTASKD 1608

Human  1606 YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTK 1670
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
Zfish  1609 YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFISKLIKHTK 1673

Human  1671 QLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISI-DELDNAELPPAPDSENATEQELEPSPPLR 1734
            ||||||||:||||||||||||||||||||||||:. ||||.|||.|.|:.|...| |.:|:.|.:
Zfish  1674 QLLEENEERLCIKVLQTLREMMTKDRGYGEKLIAFDDELDVAELAPPPEPEVPAE-EFDPNQPQK 1737

Human  1735 QLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEM 1799
            ||||.||.||||||||||||||.:|.|||:|||:|.||||:..|||..||||||.|.|:.||||:
Zfish  1738 QLEDQKRSEALRQVLVNRYYGNFKPGGRRDSLTNFSNGPLTPVGPGGGGGGGGGGGGSAGSRGEL 1802

Human  1800 SLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEK 1864
            ||||||||||:||||:|||||||||:|||:|.||||||||||||||..||.|||||||.|.||||
Zfish  1803 SLAEVQCHLDREGASDLVIDLIMNATSDRIFQESILLAIALLEGGNPVIQRSFFCRLTGDNKSEK 1867

Human  1865 FFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEV-DRDAPSRKKAKEPTTQITEEVRDQLLEA 1928
            ||||||:|||:|||||||||||||||||:|:||::. |:|..||||.|: ...||||||:|||||
Zfish  1868 FFKVFYERMKLAQQEIKATVTVNTSDLGSKRKDEDTNDKDVQSRKKVKD-VAVITEEVREQLLEA 1931

Human  1929 SAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDL 1993
            |..|:|||:|:|||||.|:|....||..:||:|.:|:.|||.:|||||||||.:|||||||||:|
Zfish  1932 STVTKKAFSTYRREADADEHLNATEGPSSTAEKNQDENEMSVIITIMQPILRLMQLLCENHNREL 1996

Human  1994 QNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCH 2058
            ||||||||||.|||||||||||||||||||||||||||||||||||||||||:||||||||||||
Zfish  1997 QNFLRCQNNKNNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTVESLTEYCQGPCH 2061

Human  2059 ENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILY 2123
            ||||||||||.||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Zfish  2062 ENQNCIATHECNGIDIIIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILY 2126

Human  2124 NMRPKELVEVIKKAYMQGEVEFE---DGENG-EDGAASPRNVGHNIYILAHQLARHNKELQSMLK 2184
            |||||||||||||||||||:|.|   ||||| |:.||||||||||||||||||||||||||:|||
Zfish  2127 NMRPKELVEVIKKAYMQGEIEVEHTDDGENGEEEHAASPRNVGHNIYILAHQLARHNKELQAMLK 2191

Human  2185 PGGQV-DGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSK 2248
            |||.. :||||||||||||||||||||||||||||||||:||||||:|||||:||||||||||||
Zfish  2192 PGGTYGEGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPNICEFLTQESKLRVYYTTERDEQGSK 2256

Human  2249 INDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFK--GVRG 2311
            |||||||||||||||||||||||||:||||:||||||||||||||||||||||||||.:  ||||
Zfish  2257 INDFFLRSEDLFNEMNWQKKLRAQPILYWCSRNMSFWSSISFNLAVLMNLLVAFFYPLEGGGVRG 2321

Human  2312 GTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKII 2376
            ||||||.|.|||.|||:||||||.||:|||||||||||||||||||||:|||||||||||.||:|
Zfish  2322 GTLEPHLSALLWAAMLVSLAIVIVLPQPHGIRALIASTILRLIFSVGLEPTLFLLGAFNVGNKVI 2386

Human  2377 FLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIK 2441
            ||||||||.|||||||:||::|||||||||||:||::|:|||.||||||||||:|||||||||||
Zfish  2387 FLMSFVGNRGTFTRGYKAMIMDVEFLYHLLYLIICSLGVFVHVFFYSLLLFDLIYREETLLNVIK 2451

Human  2442 SVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVC 2506
            |||||||||:||||||||||||||||||:.|||||||.|||:.|:|.  |...|...|||...||
Zfish  2452 SVTRNGRSIVLTAVLALILVYLFSIVGYIIFKDDFILTVDRISNKTL--EQSASKMGEFLAGAVC 2514

Human  2507 RVESGENCSSPAPREELVPAEETE------QDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKP 2565
            |.|  ||||:    |.::.|...:      :|||.||::||||||||||||||||||||||||||
Zfish  2515 RKE--ENCST----ETMMDAVGVQSSALVIEDKERTCDSLLMCIVTVLSHGLRSGGGVGDVLRKP 2573

Human  2566 SKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKF 2630
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
Zfish  2574 SKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEVLKTTCFICGLERDKF 2638

Human  2631 DNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSS 2695
            ||||||||||||.||||||||.||||||||||||:|||||||||||::.||||||||||||||||
Zfish  2639 DNKTVTFEEHIKVEHNMWHYLFFIVLVKVKDSTEFTGPESYVAEMIRDHNLDWFPRMRAMSLVSS 2703

Human  2696 DSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA 2759
            |:||||||:|:|||||||||||::|||.||:|||:||||||||||||||||||.||||||||||
Zfish  2704 DAEGEQNEIRSLQEKLESTMKLISNLSSQLTELKEQMTEQRKQKQRIGLLGHPQHMNVNPQQPA 2767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITPR1	XP_011531983.1	Ins145_P3_rec	4..225	CDD:285871	213/220 (97%)
		MIR	231..287	CDD:197746	52/55 (95%)
		MIR	232..433	CDD:280906	176/213 (83%)
		MIR	294..>321	CDD:197746	25/29 (86%)
		RYDR_ITPR	476..665	CDD:279676	173/188 (92%)
		RYDR_ITPR	1209..1340	CDD:279676	120/130 (92%)
		RIH_assoc	1974..2079	CDD:285630	97/104 (93%)
		Ion_trans	2351..2610	CDD:278921	206/264 (78%)
itpr1b	XP_021335554.1	Ins145_P3_rec	4..225	CDD:312293	213/220 (97%)
		MIR	233..446	CDD:308455	176/212 (83%)
		RYDR_ITPR	487..683	CDD:307497	180/195 (92%)
		RYDR_ITPR	1212..1325	CDD:307497	103/112 (92%)
		RIH_assoc	1977..2082	CDD:312080	97/104 (93%)
		Ion_trans	2370..2618	CDD:306908	197/255 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326833
Domainoid	1	1.000	1009	1.000	Domainoid score	I414
eggNOG	1	0.900	-	-		E1_KOG3533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1673
Inparanoid	1	1.050	4656	1.000	Inparanoid score	I54
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D3563at7742
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		oto48006
orthoMCL	1	0.900	-	-		OOG6_102308
Panther	1	1.100	-	-	LDO	PTHR13715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3112
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300