Protein Alignment Nup75 and NUP85

DIOPT Version :10

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_079120.1
• Gene: NUP85 / 79902
• HGNCID: 8734
• Length: 656
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 208/664 - (31%)
• Similarity: 346/664 - (52%)
• Gaps: 66/664 - (9%)

  Fly    29 PGSRIALSAYRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQ---- 89
            ||..:...     |..::.|.:|.....|.:..:.::..::.: :||.:..|::..|..||
Human    29 PGEMLVCE-----TSFNKKEKSEMVPSCPFIYIIRKDVDVYSQ-ILRKLFNESHGIFLGLQRIDE 87

  Fly    90 QLGSRATRAEYVNISRAYRSIVRSCLEKLEQ---AKKSPEVQTDEARLQRLCDAIVVFYAAECLW 151
            :|..::.:::.|.:|:.|||::|:|:|::.|   |.|.|      |..::....:.:..|.|.:|
Human    88 ELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDP------ANGRQFSSQVSILSAMELIW 146

  Fly   152 HLFEILYIQSNQLVVP------QLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIML 210
            :|.|||:|:    |.|      .||||.|.|....:..:.| :|..|..|:.|.:|::|..|::.
Human   147 NLCEILFIE----VAPAGPLLLHLLDWVRLHVCEVDSLSAD-VLGSENPSKHDSFWNLVTILVLQ 206

  Fly   211 GEIDVTRAVLSQNRKAGQTS---FKAAEQILKSMPVYQEG--YALQKFHSQWEFWHVDTERKIQS 270
            |.:|..|.:||:...|...|   .:....::::||:...|  ..|.:...:|:.||.:.||.:|.
Human   207 GRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQD 271

  Fly   271 GLFATEPELEQLIRLVAGDSEQWDAGIKESQD----FYEYLPGYLLFTKPTCKPFELKIAAAKWL 331
            ..|||.|.||.|::::.||    :|.:.|.::    :|.:|...||::.||.||.:|...|...|
Human   272 STFATSPHLESLLKIMLGD----EAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSL 332

  Fly   332 NRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKS---YFD 393
            :  ..|..|.....::.::....:.|:...|.:........||..||.||:.||..|:|   ||.
Human   333 D--LFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFG 395

  Fly   394 QNNIDLPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLI 458
            .|      :|..::.||.|.|....::||||:||.|.|.:.|:.::||.:.||.|.:|::|.|::
Human   396 SN------MREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVL 454

  Fly   459 NLARQRGLISVEREICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCP 523
            .:..||.:....|.|||:|:.::..|.|.|:||.|:||:||....|.|:|..|:.|.:.||....
Human   455 RICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDL 519

  Fly   524 DTIANVGGRMFASPRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPL 588
            |.|.|:|..|..|.||.||.||.||:..|..:.|..|:.||::|:.|:|.|..||.:||.|::||
Human   520 DLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPL 584

  Fly   589 LESKDPKIFAKETVAILHHIE--TDLVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLAC 651
            ||.|.....|::|..::..:|  |...|:       :|:..||.: :|..:|...  :.:|||:.
Human   585 LEQKQVIFSAEQTYELMRCLEDLTSRRPV-------HGESDTEQL-QDDDIETTK--VEMLRLSL 639

  Fly   652 ARNLARALIIENTL 665
            |||||||:|.|.:|
Human   640 ARNLARAIIREGSL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:400113	182/577 (32%)
NUP85	NP_079120.1	Nucleopor_Nup85	53..606	CDD:400113	181/576 (31%)