Protein Alignment Nup75 and nup85

DIOPT Version :10

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_001004817.1
• Gene: nup85 / 448067
• XenbaseID: XB-GENE-1008050
• Length: 653
• Species: Xenopus tropicalis
• Alignment Length: 638
• Identity: 195/638 - (30%)
• Similarity: 330/638 - (51%)
• Gaps: 52/638 - (8%)

  Fly    50 TENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQ----QLGSRATRAEYVNISRAYRSI 110
            :|.|.:.|.:..:..:..:: .||||.:..|:::.|..||    :...::.:|:.|.:||.|||:
 Frog    44 SETAARCPFMYLVRSDEDIY-SPVLRKLFNESHSIFVGLQKSAEENAGKSRKAQLVQVSRNYRSV 107

  Fly   111 VRSCLEK---LEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQS---NQLVVPQL 169
            :|:|:|:   |.::.:.|...|      :....|.:..|.|..|:|.|||:|:|   ..|:: .|
 Frog   108 LRACMEEMHALSESTREPSQNT------KYISQISILSAMELSWNLCEILFIESAPAGPLLI-LL 165

  Fly   170 LDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQNRK---AGQTSF 231
            |||.|.|....::...| :|..|..:|.:.:|..|...::.|.::..|.:|::...   :.::..
 Frog   166 LDWVRLHVCEVDNIVQD-VLRSERPTEHEKFWDGVTGYVLQGRMNEARQLLAKEASSSVSARSMC 229

  Fly   232 KAAEQILKSMPVYQEG--YALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLIRLVAGDSEQWD 294
            :..:.:||.||:....  ..|.:|..:|:.|..:.||.:|:|.|::.|.:|.:.|::.||.|.
 Frog   230 RVLDDLLKKMPMLNTAGTQTLTEFELKWQHWREECERHLQNGTFSSNPHMEVVCRVLVGDEEV-- 292

  Fly   295 AGIKESQD----FYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMD 355
              |.|.:|    :|.:|...|||..||.||.||...|...|:.:.......|  .::.::....:
 Frog   293 --ILEKRDLMTTWYHFLVSRLLFKHPTVKPTELHFYAQSSLDMFLAGNSSPE--PLDNILLAAFE 353

  Fly   356 HDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKS---YFDQNNIDLPALRHSMIYEYGSYLMTS 417
            .|:...|.:...::...||..||.||:.||...::   ||..|      :|..::.:|.|.|.:.
 Frog   354 FDIHQVIKEFSIVSSNWWFVAHLTDLLDHCQLFQAHNLYFGAN------MREFLLLDYASGLFSH 412

  Fly   418 HNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVEREICKVLSKRSY 482
            |::||||:||.|.|...|...:||.:.|:.|.:|::|.|.:.:..:|.:....|.|||.::.:|.
 Frog   413 HSLWQLGVDYFDYCPNLGHVYLELHMERVPLNTEKKALKALRICEKRQMTEQVRSICKTMAMQSL 477

  Fly   483 DNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFASPRLVFLSKYFE 547
            .|.|.|:||.|:||:||....|.::|..||.||:.|.....|.|.|:|..|..|.||.||.||.|
 Frog   478 CNGRLGSALSWSIRAKDAAFATLISDRFLKEYSERGNFTDLDLIDNLGSAMLLSDRLTFLGKYRE 542

  Fly   548 FYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESKDPKIFAKETVAILHHIETDL 612
            |:..|....|..|:.||::|:.::|.|..||.:||:|::||||.|.....|::|..::..:|
 Frog   543 FHRMYSQEQFSEAASLLLSLMTARIAPCSFWLTLLLDALPLLEQKQVIFSAEQTYELMRCLE--- 604

  Fly   613 VPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARALIIENTL 665
                :|..:|......:.:.|...|::..  :.:||||.|||||||::.|..|
 Frog   605 ----DRMAAKLDSTSPDEIQKQDSVDSTK--IEMLRLALARNLARAIVTEGAL 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:400113	174/572 (30%)
nup85	NP_001004817.1	Nucleopor_Nup85	54..605	CDD:400113	175/578 (30%)