Protein Alignment Nup75 and nup85

DIOPT Version :10

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_001003625.1
• Gene: nup85 / 445231
• ZFINID: ZDB-GENE-040801-145
• Length: 649
• Species: Danio rerio
• Alignment Length: 657
• Identity: 206/657 - (31%)
• Similarity: 341/657 - (51%)
• Gaps: 58/657 - (8%)

  Fly    29 PGSRIALSA-YRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQQL- 91
            ||..:.... |:....||...|         |:::.::......|:||.:..|::..|..||::
Zfish    29 PGDLLVYETNYKLRGSSSAGSP---------LVHVVRKDEDICSPILRKLFNESHLIFMGLQKIK 84

  Fly    92 ---GSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHL 153
               .|:..:.::|:|||.|||::|:|:|:|:|...:.:   |.:...:..|.:.:..|.|.:|:|
Zfish    85 EDAPSKNKKTQFVSISRNYRSVIRACMEELQQNAVTAQ---DGSLASQYGDQVSILLAIELIWNL 146

  Fly   154 FEILYIQ---SNQLVVPQLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDV 215
            .|:|:|:   :..|:: .||:|.|.|....:.||.: :|..|..::...||.:|.||::.|.:|.
Zfish   147 CEVLFIEAAPAGSLLL-HLLNWVRLHKSDVDTRARE-VLQSENPTQHPAYWDVVTSLVLQGRMDE 209

  Fly   216 TRAVLSQN---RKAGQTSFKAAEQILKSMPVYQEGYA--LQKFHSQWEFWHVDTERKIQSGLFAT 275
            .|.:||:.   |....:.||..:.:|::||::....|  |.:|..:|..||.:.:|.:|...||:
Zfish   210 ARQILSKQASLRMESSSVFKRMDTLLQTMPIFNPAGAQTLTEFDVKWRHWHEECDRCLQDHTFAS 274

  Fly   276 EPELEQLIRLVAGDSEQWDAGIKESQD----FYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCL 336
            ..|||.|.:::.||.:.    |.|.:|    :|.:|...||||.||.||.:|...|...:|.:
Zfish   275 SAELETLCKILLGDEDV----ILEQKDLMSTWYHFLVSRLLFTHPTIKPPDLHYYAQSSMNMF-- 333

  Fly   337 LRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKS---YFDQNNID 398
            |.|......::.::....:.||...|.|.....:..||..||.||:.||..|:|   :|..|
Zfish   334 LGPRATPEPLDIILLSAFEFDLHQVIKDCSIALNNWWFVAHLTDLLDHCKLLQSHNLHFGSN--- 395

  Fly   399 LPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQ 463
               ||..::.||.|.|.|.|::|||.:||||.|.:.|:..:||.:.|:.|.:||:|.|::.:...
Zfish   396 ---LREFLVLEYASGLFTHHSLWQLAVDYLDHCPEFGRVYLELQIERVPLDTERKANKVLRICED 457

  Fly   464 RGLISVEREICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIAN 528
            |.:....|.|||:::||:..|.|.|:||.|:||:||..|.|.:::..|:.||..|.....|.:.|
Zfish   458 RQMSEQVRSICKIMAKRALRNNRLGSALSWSIRAKDAALATLISERFLQDYSNKGSFTDLDVLDN 522

  Fly   529 VGGRMFASPRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESKD 593
            :|..|..|.||.||.||.||:..|....|..|::||::|:.:||.|...|.:||.|::||||.::
Zfish   523 LGPAMLLSDRLTFLGKYREFHRLYGENRFSDAAKLLLSLMMAKIAPRSLWMTLLTDALPLLEQEE 587

  Fly   594 PKIFAKETVAILHHIETDLVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARA 658
            ......:|..::..:|.     :........:...|...:..:.|       |||:|.|||||.|
Zfish   588 VIFTVDQTYELMSCLEE-----LNSGTKDSNQMEQEEDLESTKTE-------LLRVALARNLATA 640

  Fly   659 LIIENTL 665
            ::.|.|:
Zfish   641 IVKEGTI 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:400113	185/569 (33%)
nup85	NP_001003625.1	Nucleopor_Nup85	51..604	CDD:400113	185/569 (33%)