Protein Alignment Nup75 and Nup85

DIOPT Version :9

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_001020572.1
• Gene: Nup85 / 287830
• RGDID: 1311942
• Length: 656
• Species: Rattus norvegicus
• Alignment Length: 653
• Identity: 204/653 - (31%)
• Similarity: 339/653 - (51%)
• Gaps: 65/653 - (9%)

  Fly    42 THSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQ----QLGSRATRAEYVN 102
            |..::.:.:|.....|.:..:.::..::.: :||.:..|::..|..||    :|..::.:|:.|.
  Rat    37 TSFNKTDKSEKVPSCPFIYIIRKDVDVYSQ-ILRKLFNESHGIFVGLQRLEEELSGKSRKAQLVR 100

  Fly   103 ISRAYRSIVRSCLEKLEQ---AKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQSNQL 164
            :|:.|||::|:|:|::.|   |.|.|      |..::....:.:..|.|.:|:|.|||:|:
  Rat   101 VSKNYRSVIRACMEEMHQVAIAAKDP------ASGRQFSSQVSILSAMELIWNLCEILFIE---- 155

  Fly   165 VVP------QLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQN 223
            |.|      .||||.|.|....:..:.| :|..:..|:.:.:|::|..|::.|.:|..|.:||:.
  Rat   156 VAPAGPLLLHLLDWVRLHVCEVDSLSAD-VLGSDHPSKHESFWNLVTVLVLQGRLDEARQMLSKE 219

  Fly   224 RKAGQTS---FKAAEQILKSMPVYQEG--YALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLI 283
            ..|..:|   .:....::::||:...|  ..|.:...:|:.|..:.||.:|...||..|.||.|.
  Rat   220 ADASPSSAGMCRVLGDLMRTMPILSPGNTQTLTELELKWQHWREECERHLQDNTFAANPHLESLC 284

  Fly   284 RLVAGDSEQWDAGIKESQD----FYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCLLRPEREQC 344
            :::.||    :|.:.|.::    :|.:|...||::.||.||.:|.:.|...|:.:  |..|....
  Rat   285 KIMLGD----EATLLEQKELMSNWYHFLVTRLLYSNPTVKPTDLHLYAQSSLDMF--LGGESSPE 343

  Fly   345 SMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKS---YFDQNNIDLPALRHSM 406
            .::.::....:.|:...|.:........||..||.||:.||..|:|   ||..|      :|..:
  Rat   344 PLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCRLLQSHNLYFGSN------MREFL 402

  Fly   407 IYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVER 471
            :.||.|.|...|::||||:||.|.|.:.|:.::||.:.||.|.:|::|.|::.:..||.:.....
  Rat   403 LLEYASGLFAHHSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVG 467

  Fly   472 EICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFAS 536
            .|||:|:.::..|.|.|:||.|:||:||....|.|:|..|:.|.:.||....|.|.|:|..|..|
  Rat   468 SICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLS 532

  Fly   537 PRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESKDPKIFAKET 601
            .||.||.||.||:..|..:.|..|:.||::|:.|:|.|..||.:||.|::||||.|.....|::|
  Rat   533 DRLTFLGKYREFHRLYGEKRFGDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQT 597

  Fly   602 VAILHHIETDLV----PIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARALIIE 662
            ..::..:| ||.    ...|.|..:......||.    :||       :||||.|||||||:|.|
  Rat   598 YELMRCLE-DLASRRPECGEPDAQRLQDDDIETT----KVE-------MLRLALARNLARAIIRE 650

  Fly   663 NTL 665
            .:|
  Rat   651 GSL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:311504	178/575 (31%)
Nup85	NP_001020572.1	Nucleopor_Nup85	53..606	CDD:284900	179/577 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336868
Domainoid	1	1.000	305	1.000	Domainoid score	I1326
eggNOG	1	0.900	-	-		E1_KOG2271
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11755
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2454
OMA	1	1.010	-	-		QHG58410
OrthoDB	1	1.010	-	-		D443305at33208
OrthoFinder	1	1.000	-	-		FOG0003500
OrthoInspector	1	1.000	-	-		oto98056
orthoMCL	1	0.900	-	-		OOG6_104020
Panther	1	1.100	-	-	LDO	PTHR13373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770