Protein Alignment Nup75 and nup85

DIOPT Version :9

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_595893.1
• Gene: nup85 / 2539829
• PomBaseID: SPBC17G9.04c
• Length: 675
• Species: Schizosaccharomyces pombe
• Alignment Length: 669
• Identity: 137/669 - (20%)
• Similarity: 232/669 - (34%)
• Gaps: 195/669 - (29%)

  Fly    20 GNTLTGVFVPGSRIALSAYRHVTHSSRDEPT---ENAGQVPVLIY-MAQESTLFD---------- 70
            |.|:.....|..|..|:   ::.:...||.|   :...:|..|:| .:..|||.:
pombe    31 GRTVAFKLHPFLRKGLA---YINNKEFDENTLKSDKFEEVESLVYEFSTPSTLIEPNYLLTAWHE 92

  Fly    71 ----------EPVLRSVLAEANATFATLQQLGSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSP 125
                      .|:|.|   |||....|          ..|..||..:||.:...||:|:.
pombe    93 LWEELQDTYMTPILDS---EANLLLLT----------QFYGKISSLFRSKIIQVLEELQS----- 139

  Fly   126 EVQTDEARLQRLCDAIVVFYAAECLWHLFEILYI--QSNQLVVPQLLDWARFHSPH--AEDRATD 186
            .:...|...|.:.|::   :..|..|...|.:|.  .|...:...:|||...:.|.  |:|   .
pombe   140 RINEGEKDCQPVLDSL---WEVESAWRCAEAIYFPPSSPYTLSTGILDWVNAYDPQPIADD---G 198

  Fly   187 LLLMGEEAS-ESDDYWSIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKSMPVYQEGY-- 248
            |.:|..... :..::|..|....:.|..:.|.:.|..   :|.|         |..||.:|..
pombe   199 LEIMAYRIPYQHPEFWPYVNKTAIRGLFEQTISCLEM---SGLT---------KEWPVLKETVDE 251

  Fly   249 -----------------ALQKFHSQWEFWH---------VDTERKIQSGLFATEPELEQLIRLVA 287
                             ::..|..:|:.|.         |...|.|.|.:.   .:...|:.::.
pombe   252 LIDILRYSPCTHQKRIRSVSDFERRWKLWRSRLANLRHVVKKHRDIDSEVL---DDFVVLLDILN 313

  Fly   288 GDSEQWDAGIKESQDFYEYLPGYLLFTKPTCK-PFEL----KIAAAKWLNRWCLLRPEREQCSMN 347
            |:.|.........|:::..|.  .|:....|| |.::    ::|..:....:.....|.||..:|
pombe   314 GNKEVIMLSCAHWQEYFSALA--FLYGPLDCKNPEDISLLYQLATGEDSKFYVNGTIEYEQICVN 376

  Fly   348 RMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKSYFDQNNIDLP-ALRHSMIYEYG 411
            ...::.::.....::.|.       ..:.||.||:...|.|:.|..:   :.| .||..:|.|||
pombe   377 LCSNEPLNAIKHAYLLDL-------GLAVHLADLLSKSGHLRDYITE---EYPITLREHLILEYG 431

  Fly   412 SYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRS-ERQATKLINLARQRGLISVEREICK 475
            ..::.|.|:||....|..|....|...|:..:|.:.|.. :.:.|.|              ::||
pombe   432 QCVLESRNLWQTSFAYWKCVADSGYQRIKACIPYVPLSDVDAKETAL--------------QLCK 482

  Fly   476 VLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFIL--KHYSKTGCMLCPDTIANVGG------- 531
            .|.                :|.:..|::|..||.::  .||.:  .::..|..||...
pombe   483 QLK----------------LRDEAQLVLTHWADELIARNHYGE--ALIALDNAANYSALNRVTWE 529

  Fly   532 ---------------------RMFASPR------------LVFLSKYFEFYEFYRTRDFLSASEL 563
                                 .:|:||:            ...:.:|| ||..::..  |:||||
pombe   530 LFDICIAEKKSFSPDKDELLYELFSSPKACTPTLASIISPAATIHQYF-FYLQHKKE--LNASEL 591

  Fly   564 LVNLLESKITPDYFWPSLL 582
            ||.||.....|...:|.||
pombe   592 LVGLLTMVDFPSSRFPKLL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:311504	128/627 (20%)
nup85	NP_595893.1	Nucleopor_Nup85	70..644	CDD:284900	128/627 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3027
eggNOG	1	0.900	-	-		E1_KOG2271
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I2000
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003500
OrthoInspector	1	1.000	-	-		oto101766
orthoMCL	1	0.900	-	-		OOG6_104020
Panther	1	1.100	-	-	LDO	PTHR13373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3890
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.890