Protein Alignment Nup75 and npp-2

DIOPT Version :10

• Sequence 1: NP_611300.2
• Gene: Nup75 / 37078
• FlyBaseID: FBgn0034310
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_492256.1
• Gene: npp-2 / 172611
• WormBaseID: WBGene00003788
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 633
• Identity: 133/633 - (21%)
• Similarity: 232/633 - (36%)
• Gaps: 111/633 - (17%)

  Fly    62 MAQESTLFDEPVLRSVLAEANATFATLQQLGSRATRAE---YVNISRAYRSIVRSCLEKLEQAKK 123
            ::|...:...|.||.::.|..:.|...|:..|.....:   ....||||||:    |.....:..
 Worm    39 VSQNRQILATPNLRRLVIEMYSVFDKCQKGSSPDAPLDTPTCCTFSRAYRSV----LYNAAVSHS 99

  Fly   124 SPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYI-QSNQLVVPQLLDWAR---FHSPHAEDRA 184
            |.:..||.|                 ||.|:|.|:. :.:..:...|:.||.   ..|..|.:.|
 Worm   100 SSDFMTDFA-----------------LWSLYEKLWFGRGDSSICADLISWANQSFTFSRGAMESA 147

  Fly   185 TDLLLMGEEASESDDYW-SIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKSMPVYQEGY 248
            .:.|..|:...|  :|| .:..||:.....|...  |.:....|.......|.:....|......
 Worm   148 VEYLHPGKTIPE--EYWKGVAVSLLSCNFSDCVE--LLELHGGGSECDAFIEALTFFNPENLVDE 208

  Fly   249 ALQKFHSQWEFWHVDTERK-IQSGLFATEPELEQLIRLVAGDSEQWDAGIKESQD-FYEYLPGYL 311
            ||....::|:    |..|: :.||.:.:....:.|.:|:.|:.....:......| ::.:||.::
 Worm   209 ALANTVNEWK----DIMRENLTSGKYGSNENFKYLTKLLLGEERYLVSMASRIFDTWWHFLPFFV 269

  Fly   312 LFTKPTCKPFELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFST 376
            |...|.....|| |..|.......:...|.|....|.:...|:..|   .|...|.:....|.:.
 Worm   270 LVKNPFAGHVEL-IELADECRTLFVGEEEEEGAKENDVFWCLISKD---DINFQQLIASNPWLAV 330

  Fly   377 HLIDLIHHCGQLKSYFDQNNIDLPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIEL 441
            ||:||||     ||..|.   :...:|...:.:|.|.|::...:|::|..||..|..||...:|.
 Worm   331 HLVDLIH-----KSTLDP---EFEVMRKMHMLDYASVLISHSPLWEIGAGYLIACGTEGLLRLET 387

  Fly   442 LLPRITLRSERQATKLINLARQRGLISVEREICKVLSKRSYDNERYGNALEWAIR---------- 496
            .:..:.:..:..|.:|:.:..:..|...:..:...::.|......:.:.|.||::
 Worm   388 HIEGLHIEDDEMAEQLLEICEEHRLEDAKSCVTNTMTFRYLKQGHWSSTLAWALKTGSKKTIDWT 452

  Fly   497 --------SKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFASPRLVFLSKYFEFYEFYR 553
                    |||.|....|...|..|                  .:.:.|.|.||..|..|.:...
 Worm   453 VSRIVGSSSKDELAALRVLSSITNH------------------SVLSLPSLTFLYSYQRFVKMMH 499

  Fly   554 TRDFLSASELLVNLLESKITPD----YFWPSLLIDSMPLLESKDPKI---FAKETVAILHHIETD 611
            ..|.|...:.|:.|:   :.||    |::.  |.|.:..:..:|.:.   |:||   ||:.:.|.
 Worm   500 CGDVLDCVQHLIPLI---MMPDVPTQYYYD--LFDYLITIIKEDGRAGIRFSKE---ILYELSTF 556

  Fly   612 LVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARAL 659
            |      ......||..   ..|..::.|..:..::.|....::|:.:
 Worm   557 L------STFTLDKHRD---LNDNYMKKVKVLKKMVMLKLTDSIAKGI 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup75	NP_611300.2	Nucleopor_Nup85	59..610	CDD:400113	125/582 (21%)
npp-2	NP_492256.1	Nucleopor_Nup85	35..559	CDD:400113	127/592 (21%)