Protein Alignment Naus and CTTNBP2

DIOPT Version :10

• Sequence 1: NP_611299.2
• Gene: Naus / 37076
• FlyBaseID: FBgn0034308
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_219499.1
• Gene: CTTNBP2 / 83992
• HGNCID: 15679
• Length: 1663
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 160/634 - (25%)
• Similarity: 235/634 - (37%)
• Gaps: 183/634 - (28%)

  Fly    82 SELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRE 146
            |||..:|..:||||:|||:.|.|||..| |::..|.|..|...|||:.|:.||..|..|:...:.
Human    39 SELRMLLSVMEGELEARDLVIEALRARR-KEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKP 102

  Fly   147 SSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENT 211
            ..|...       .|:|..|....:|..:..|                  .|...|..::|
Human   103 VCTNPL-------SILEAVMAHCKKMQERMSA------------------QLAAAESRQKK---- 138

  Fly   212 TAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERKKIL 276
                                 ||.|:.|:..:|::.|||...||.||.:.||:||:|:.|.|::.
Human   139 ---------------------LEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS 182

  Fly   277 MKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAKLAK 341
            .|.|||.::.||:...|.|||::::.:.|.|..|.::|..||.::|||....:.||:.|.|||.:
Human   183 GKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNR 247

  Fly   342 EELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKARQFSDDACATPPMVNIAKIVQPTAT 406
            ||....:|::|::.:|...|.||:     ||.|..:.:..|:..|..     :|:|:...:.|.|
Human   248 EEAHTTDLKEEIDKMRKMIEQLKR-----GSDSKPSLSLPRKTKDRR-----LVSISVGTEGTVT 302

  Fly   407 VS--------------------SMPVSGPQTG--IARSIAPGQNIRSAGIATAP----------T 439
            .|                    :|||. |.||  :..:.|.|....||.:|...          .
Human   303 RSVACQTDLVTENADHMKKLPLTMPVK-PSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLI 366

  Fly   440 GTATAAIAPLTAVLNHTTTITTTTNNTTTSSNSNSSGSIGVAATAAAVAASVETAATVTVPMVAP 504
            |.:..|..|.:|              .....|..|:||.....::.....|.....|...|.:||
Human   367 GASVPAFPPPSA--------------NKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAP 417

  Fly   505 PS----PSPAKMQPTATIQRAPG------------------------------------------ 523
            .:    |..:...|.|.....||
Human   418 QNSQAPPMHSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNL 482

  Fly   524 --GKYAALAAAAALDQTTTPHP-HPVPIAVPPV----TVPPAGA------------RGAPPPIPT 569
              .:.|......||.:.|:|.. .|....|||.    |.||.|.            ||.|||||.
Human   483 VAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPP 547

  Fly   570 K----PIVPPKREPSL-----SRLGSITGSSAIAAATAATTAAGTAKQN 609
            |    ...|....|.|     |...|.||:. :...|.|:|.:...:.|
Human   548 KKPGLSQTPSPPHPQLKVIIDSSRASNTGAK-VDNKTVASTPSSLPQGN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_611299.2	CortBP2	78..274	CDD:462860	55/191 (29%)
		SMC_prok_B	<187..>384	CDD:274008	59/196 (30%)
		PHA03247	<496..587	CDD:223021	34/164 (21%)
CTTNBP2	NP_219499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		CortBP2	36..180	CDD:462860	55/191 (29%)
		DR0291	123..>264	CDD:441187	52/183 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..222		5/18 (28%)
		PHA03247	<351..718	CDD:223021	51/260 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..440		16/86 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..478		0/23 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..616		29/99 (29%)
		ANKYR	698..970	CDD:440430
		ANK 1	709..739
		ANK repeat	712..741	CDD:293786
		ANK repeat	743..774	CDD:293786
		ANK 2	743..772
		ANK repeat	776..807	CDD:293786
		ANK 3	776..805
		ANK repeat	809..840	CDD:293786
		ANK 4	809..838
		ANK 5	842..871
		ANK 6	912..942
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1449..1482
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1581..1663