Protein Alignment Naus and LUZP1

DIOPT Version :10

• Sequence 1: NP_611299.2
• Gene: Naus / 37076
• FlyBaseID: FBgn0034308
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_361013.3
• Gene: LUZP1 / 7798
• HGNCID: 14985
• Length: 1076
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 129/696 - (18%)
• Similarity: 219/696 - (31%)
• Gaps: 279/696 - (40%)

  Fly   119 TKRLQPNDPYAAIFRDKIALNGNLISRESSTQAAQAEMEV-RQ--------------------II 162
            ||.||..:......:||:      |..|.|..:..||:|| ||                    ::
Human    34 TKNLQKAEDELLDLQDKV------IQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLM 92

  Fly   163 EQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERN 227
            ::::|::..:..:.::.        .|.|:.....|::|||...:.:|...|   :...|..|||
Human    93 KEKLEEEENLTRELKSE--------IERLQKRMAELEKLEEAFSRSKNDCTQ---LCLSLNEERN 146

  Fly   228 ---KLKQDLEEERAQVAKMEKD---LKKLQETLEYERNRQKQIVLLLIAERKKILMKYIEEGKRS 286
               |:..:||..|.:|.::|..   |.|.:::|..|..:.|.:.|..::|||.:..|..|..|..
Human   147 LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLI 211

  Fly   287 EDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERK--VLFAKLAKEELR---- 345
            ::|.|.|.:.|:.:...........:..||:|:.:.....:.|..||  :.:.|..:.|.|
Human   212 KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE 276

  Fly   346 -----------VKELEQELNALRS--------EHE------------------------------ 361
                       ||:|.||:..|::        |.|
Human   277 NEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLE 341

  Fly   362 ----ALKKQQQL-------------------------GGSGSSVAAAKARQ-------------- 383
                .:|||::|                         .||.:||:...||:
Human   342 EIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406

  Fly   384 ---------FSDDACATPPMVNIAKIVQPTATVSSMPV---SGPQ-------------------- 416
                     .|:...::|...|     :..|..|.|.|   ||.|
Human   407 FALNNENYSLSNRQVSSPSFTN-----RRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKK 466

  Fly   417 -----TGIARSIAPGQNIRSAGIATAPTGTATAAIAPLTAVLNHTT-TITTTTNNT--------- 466
                 :.::|.....|....|...|:..||.:.    |...:..|| |.:.||:.:
Human   467 SREQPSVLSRYPPAAQEHSKAWKGTSKPGTESG----LKGKVEKTTRTFSDTTHGSVPSDPLGRA 527

  Fly   467 -------------------------TTSSNSNSSGSIGVAA-----TAAAVAASVETAATVTVPM 501
                                     |.::||..|.:||..|     ::..::...:.|..:....
Human   528 DKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADN 592

  Fly   502 VAPPSPSPAKM-------------------------QPTATIQ--------------RAPGGK-- 525
            ..|.|.:|...                         ||.|.:.              ::.|.:
Human   593 SCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKP 657

  Fly   526 -------YAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAP 564
                   .|:|..|..::.|.||.|.|.|   .|.:...|..||||
Human   658 DSDDDLDIASLVTAKLVNTTITPEPEPKP---QPNSREKAKTRGAP 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_611299.2	CortBP2	78..274	CDD:462860	42/181 (23%)
		SMC_prok_B	<187..>384	CDD:274008	61/309 (20%)
		PHA03247	<496..587	CDD:223021	22/117 (19%)
LUZP1	NP_361013.3	Mplasa_alph_rch	<29..355	CDD:275316	71/337 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..291		8/44 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..546		28/196 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..600		3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..746		12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..819
		Required for interaction with FLNA. /evidence=ECO:0000269|PubMed:30990684	833..883
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..913
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	929..998
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1076