DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naus and CTTNBP2NL

DIOPT Version :9

Sequence 1:	NP_001286565.1	Gene:	Naus / 37076	FlyBaseID:	FBgn0034308	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_061174.1	Gene:	CTTNBP2NL / 55917	HGNCID:	25330	Length:	639	Species:	Homo sapiens

Alignment Length:	656	Identity:	174/656 - (26%)
Similarity:	278/656 - (42%)	Gaps:	167/656 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRES 147
            ||:.:...|||||:|||:.|.||:.:.....|.: |..:...:||..|:.||...|      :|.
Human    10 ELLTLFSILEGELEARDLVIEALKAQHRDTFIEE-RYGKYNISDPLMALQRDFETL------KEK 67

  Fly   148 STQAAQA----EMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKH 208
            :....|.    .:.:.:::.:|.:...:          ||::.|..:...:::::.:||||:::|
Human    68 NDGEKQPVCTNPLSILKVVMKQCKNMQE----------RMLSQLAAAESRHRKVILDLEEERQRH 122

  Fly   209 ENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERK 273
            ...||:|||:||.||.||.:|.|.||.|::||.|.||:.|||...||.||:|.||:..:|:.|.|
Human   123 AQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK 187

  Fly   274 KILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAK 338
            |...|..|||:::.:|:..|.:||.|...:.|.|..|.|:.|:.|.::|||....:.||:.|.||
Human   188 KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAK 252

  Fly   339 LAKEELRVKELEQELNALR-------------SEHEALKKQQQLGGSGSSVAAAKARQFSDDACA 390
            |.:||.|.|.|::|:.:|:             |.:|.|||         .|..:|       ..|
Human   253 LNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK---------PVTVSK-------GTA 301

  Fly   391 TPPMV-------------------NIAKIVQ------PTATVSSMPVSG---PQTGIARSIAPGQ 427
            |.|::                   ||||:..      .|...|....:|   |:....|.:..|.
Human   302 TEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTRELTAGN 366

  Fly   428 NI------RSAGIATA----------PTG--TATAAIAPLTAVLNHTTTITTTTNNTTTS----- 469
            |:      |...:|.|          |.|  |.....:||::..:..:..:|.:::.|:|
Human   367 NVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTASSSLTSSPCSSP 431

  Fly   470 --------SNSNSSG-----SIGVAATAAAVAASVETAATVTVPMVAPPSPSPAKMQPTA----- 516
                    |:::|.|     .:|:.....|.....::.|..........||....:.||.
Human   432 VLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLIDNSA 496

  Fly   517 ----------------TIQRAP-----------GGKYAALAAAAALDQTTTPHPHPVPIAVP--P 552
                            |.|:.|           |..|..||..|.....|:..|.|..::.|  |
Human   497 AKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTANPRGDTSHSPTPGKVSSPLSP 561

  Fly   553 V-------TVPPAGARGAPPPI-PTKPIVPPKREPSL--------SRLGSITGSSAIAAATAATT 601
            :       |:|.| .||.|||| |.||.:.|  .||.        |:..|:|.:..:|::.::.|
Human   562 LSPGIKSPTIPRA-ERGNPPPIPPKKPGLTP--SPSATTPLTKTHSQAASLTTAEDLASSCSSNT 623

  Fly   602 AAGTAK 607
            .....|
Human   624 VVANGK 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_001286565.1	CortBP2	78..274	CDD:286770	65/194 (34%)
Naus	NP_001286565.1	Angiomotin_C	189..381	CDD:289044	77/204 (38%)
CTTNBP2NL	NP_061174.1	CortBP2	5..188	CDD:286770	65/194 (34%)
		RILP-like	<96..246	CDD:304877	61/149 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..430		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..490		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..609		29/100 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142159
Domainoid	1	1.000	104	1.000	Domainoid score	I6701
eggNOG	1	0.900	-	-		E1_KOG1103
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4235
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006973
OrthoInspector	1	1.000	-	-		otm41990
orthoMCL	1	0.900	-	-		OOG6_109427
Panther	1	1.100	-	-	O	PTHR23166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750