Protein Alignment Naus and OTOG

DIOPT Version :10

• Sequence 1: NP_611299.2
• Gene: Naus / 37076
• FlyBaseID: FBgn0034308
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001264198.1
• Gene: OTOG / 340990
• HGNCID: 8516
• Length: 2925
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 69/272 - (25%)
• Similarity: 99/272 - (36%)
• Gaps: 87/272 - (31%)

  Fly   391 TPPMVNIAKIVQPTATVSSMPVSGPQTGIARSIAPGQNIRSAGIATAPT--GTATAAIAP-LTAV 452
            |||..::      ||:.||.||:.|                ..|:.:||  |:..|.:.| :|.|
Human  1645 TPPQPSL------TASPSSRPVASP----------------GAISRSPTSSGSHKAVLTPAVTKV 1687

  Fly   453 LNHTTTITTTTNNTTTSSNSNSSGSIGVAATAA--------------AVAASVETAATVTVPMVA 503
            ::.    |.....|...|.|:.|..:.||.|||              .|.::.:..|..:.||.:
Human  1688 ISR----TGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGS 1748

  Fly   504 PPSPSPAKM--------QPTATIQRAPGGKYAAL----AAAAALDQTT-----TP-------HPH 544
            |.||.|..:        |.|....|:|     ||    .|||:|...|     ||       .|.
Human  1749 PASPQPHPLPSAPPRPAQHTTMATRSP-----ALPPETPAAASLSTATDGLAATPFMSLESTRPS 1808

  Fly   545 PVPIAVPPVTVPPAGARGAPPPI----PTKPIVPPKREPSLSRLGSITGSSAIAAATAATT---- 601
            .:...:||.|..|....|...|:    |...::....:|..:.|.:.|.|..:....||.|
Human  1809 QLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1873

  Fly   602 -------AAGTA 606
                   |||||
Human  1874 PTHIAPPAAGTA 1885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_611299.2	CortBP2	78..274	CDD:462860
		SMC_prok_B	<187..>384	CDD:274008
		PHA03247	<496..587	CDD:223021	29/118 (25%)
OTOG	NP_001264198.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..69
		VWD	152..302	CDD:459671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..335
		C8	349..412	CDD:462584
		TIL	426..474	CDD:460351
		VWC_out	476..>511	CDD:214565
		VWD	514..669	CDD:459671
		C8	713..767	CDD:462584
		TIL	780..844	CDD:410995
		TIL	884..946	CDD:410995
		VWD	977..1131	CDD:214566
		C8	1166..1240	CDD:214843
		beta-trefoil_ABD_OTOG	1245..1396	CDD:467810
		PHA03247	<1476..2041	CDD:223021	69/272 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1540
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1679		14/55 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1693..1715		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1737..1788		16/55 (29%)
		VWD	2112..2266	CDD:459671
		C8	2304..2370	CDD:214843
		TIL	2373..2434	CDD:460351
		Rossmann-fold NAD(P)(+)-binding proteins	<2676..2736	CDD:473865
		CT	2842..2924	CDD:214482