DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naus and Cttnbp2

DIOPT Version :9

Sequence 1:	NP_001286565.1	Gene:	Naus / 37076	FlyBaseID:	FBgn0034308	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_525024.1	Gene:	Cttnbp2 / 30785	MGIID:	1353467	Length:	1648	Species:	Mus musculus

Alignment Length:	687	Identity:	165/687 - (24%)
Similarity:	250/687 - (36%)	Gaps:	247/687 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRE 146
            |||..:|..:||||:|||:.|.|||..| |::..|.|..|...|||:.|:.||..|..|:
Mouse    39 SELRMLLSVMEGELEARDLVIEALRARR-KEVFIQERYGRFNLNDPFLALQRDYEAGPGD----- 97

  Fly   147 SSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENT 211
                                        |::......::||...:.:.::|          .|..
Mouse    98 ----------------------------KEKPVCTNPLSILEAVMAHCRKM----------QERM 124

  Fly   212 TAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERKKIL 276
            :||       |....::.|: ||.|:.|:..:|::.|||...||.||.:.|.:||:|:.|.|::.
Mouse   125 SAQ-------LVAAESRQKK-LEMEKLQLQALEQEHKKLAAHLEEERGKNKHVVLMLVKECKQLS 181

  Fly   277 MKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAKLAK 341
            .|.:||.::.|::...|.|||:::..:.|.|..|.::|..||.:||||....:.||:.|.|||::
Mouse   182 GKVVEEAQKLEEVMAQLEEEKKKTSELEEQLSAEKQRSSGMEAQLEKQLSEFDTEREQLRAKLSR 246

  Fly   342 EELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKARQFSDD-----------------AC 389
            ||....:|::|::.::...|.:||     ||......:..|:..|.                 ||
Mouse   247 EEAHTTDLKEEIDKMKKMMEQMKK-----GSDGKPGLSLPRKTKDKRLASISVATEGPVTRSVAC 306

  Fly   390 AT------------------------PPMV------NI---AKIVQ----------------PTA 405
            .|                        .|:|      |:   |.:::                |||
Mouse   307 QTDVVTESTDPVKKLPLTVPIKPSTGSPLVPTNTKGNVGPSALLIRPGIDRQSSHSDLGPSPPTA 371

  Fly   406 TVSS---MPVSGPQTGIARSIAPGQNIRSAGIATAPTGTATAAI-APLTAVLNHTTTITTTT--- 463
            ..||   :..:||.||.|..:       |....:.|:.||.||. .|.||..||:...|..:
Mouse   372 LPSSANRIEENGPSTGNAPDL-------SNSTPSTPSSTAPAAAQTPGTAPQNHSQAPTVHSLHS 429

  Fly   464 -------------------------------NNTT------------------------------ 467
                                           |||.
Mouse   430 PCANTHPGLNPRIQAARFRFQGNANDPDQNGNNTQSPPSRDVSPTSRDNLVAKQLARNTVTQALS 494

  Fly   468 --TSSNSNSSGSIGV-----AATAAAVA-ASVETAATVTVPMVAPPSPSPAKMQPTATIQRAPGG 524
              ||..:.:|..:||     |.|...|. ..::|.....|....||...|.|          ||
Mouse   495 RFTSPQAGASSRLGVSPGGDAGTCPPVGRTGLKTPGAARVDRGNPPPIPPKK----------PG- 548

  Fly   525 KYAALAAAAALDQTTTPHPHP-------------VPIAVPPVTVPPAGARGAPPPIP--TKPIVP 574
                      |.||.:| |||             ..:|.||.|:|..........:|  :.|.:|
Mouse   549 ----------LSQTPSP-PHPQLRASNAGAKVDNKIVASPPSTLPQGTKVVNEENVPKSSSPQLP 602

  Fly   575 PKREPSLSRLGSITGS--SAIAAATAATTAAGTAKQN 609
            ||  ||:....:..|.  ||:|.:......|||...|
Mouse   603 PK--PSIDLTVAPAGCPVSALATSQVGAWPAGTPGLN 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_001286565.1	CortBP2	78..274	CDD:286770	54/191 (28%)
Naus	NP_001286565.1	Angiomotin_C	189..381	CDD:289044	57/191 (30%)
Cttnbp2	NP_525024.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		CortBP2	36..179	CDD:286770	54/191 (28%)
		HrpB7	108..258	CDD:286561	53/167 (32%)
		DUF4472	133..239	CDD:291409	39/106 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..250		21/49 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..439		26/123 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..476		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..608		35/139 (25%)
		Ank_2	674..764	CDD:289560
		ANK 1	699..729
		ANK repeat	702..731	CDD:293786
		ANK	728..853	CDD:238125
		ANK repeat	733..764	CDD:293786
		ANK 2	733..762
		Ank_2	738..829	CDD:289560
		ANK repeat	766..797	CDD:293786
		ANK 3	766..795
		ANK repeat	799..830	CDD:293786
		ANK 4	799..828
		Ank_2	804..925	CDD:289560
		ANK	828..>953	CDD:238125
		ANK 5	832..861
		ANK repeat	901..933	CDD:293786
		ANK 6	901..931
		PRK11331	<1071..1357	CDD:183088
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1438..1492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1522..1648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6696
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44041
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870