DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naus and FILIP1

DIOPT Version :9

Sequence 1:	NP_001286565.1	Gene:	Naus / 37076	FlyBaseID:	FBgn0034308	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001276916.1	Gene:	FILIP1 / 27145	HGNCID:	21015	Length:	1216	Species:	Homo sapiens

Alignment Length:	298	Identity:	86/298 - (28%)
Similarity:	152/298 - (51%)	Gaps:	21/298 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EMPHSELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNL 142
            |:...:|:::|..:|||||||:..|..|:.|:.|..:.:......:|......:.||.|
Human    77 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAI------ 135

  Fly   143 ISRESSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRK 207
                    .||.:.....:.|:.:.:..::..||:.|:.||:..|..:.:.::|.:.|||.||.|
Human   136 --------LAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK 192

  Fly   208 HENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAER 272
            |.:...:.||.|..||.||.:||:.||:|:|..|:.||:..|....|..|..:.|...|:|:.||
Human   193 HTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER 257

  Fly   273 KKILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFA 337
            :..:.:...:.::.:||.|.|.||:::...|....:|:.:|.|::|.:.|.:.....||.:.:.|
Human   258 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 322

  Fly   338 KLAKEE-----LRVK--ELEQELNALRSEHEALKKQQQ 368
            |||.:|     ||:|  .|.|.:..|...::.|:|.::
Human   323 KLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_001286565.1	CortBP2	78..274	CDD:286770	59/195 (30%)
Naus	NP_001286565.1	Angiomotin_C	189..381	CDD:289044	59/187 (32%)
FILIP1	NP_001276916.1	CortBP2	77..258	CDD:286770	58/194 (30%)
		PRK03918	<208..741	CDD:235175	47/153 (31%)
		RILP-like	<262..364	CDD:304877	27/99 (27%)
		DUF972	389..>461	CDD:283750
		RILP-like	<428..532	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010