DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naus and cttnbp2nla

DIOPT Version :9

Sequence 1:	NP_001286565.1	Gene:	Naus / 37076	FlyBaseID:	FBgn0034308	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_003198883.2	Gene:	cttnbp2nla / 100534706	ZFINID:	ZDB-GENE-140106-51	Length:	494	Species:	Danio rerio

Alignment Length:	555	Identity:	152/555 - (27%)
Similarity:	246/555 - (44%)	Gaps:	91/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 ATATNGRTRSEMPHSELVKMLY-YLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAI 131
            |..|..|...|......|.:|: .|||||:|||..|.||:.:.....:.: |..:...:||:.|:
Zfish     2 APTTEPRLNVEALSKRDVLLLFSVLEGELEARDFVIQALKAQHKDSYVCE-RYGKYNLSDPFLAL 65

  Fly   132 FRDKIALNGNLISRE---SSTQ------AAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNIL 187
            .||...|..:..:||   ||:|      .|:|..:...:::       .:|...|....:|:..|
Zfish    66 QRDSETLQSSSQTREDRASSSQRRDGVCGAKARSDPLAVLK-------LVVGHCRRMQEKMLKQL 123

  Fly   188 TESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQE 252
            ..:...::|::.:||||||||...||:|||:||.||.||.:|.|.||.|:::.::||::.|:|.:
Zfish   124 AAAENRHRRVIADLEEEKRKHAEDTAEGDDVTYILEKERERLLQQLEFEKSKTSRMERENKRLHD 188

  Fly   253 TLEYERNRQKQIVLLLIAERKKILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRM 317
            .|..::.:|||::..|..|.|:...:..||.:|:.:|:|.|..|:..:.|:...||||.|::::|
Zfish   189 QLNEQQVQQKQLMTALSRECKRSGTRAYEESQRAAELSQRLERERAANQTLRAELEEEKKRAMQM 253

  Fly   318 EEELEKQTHAMEQERKVLFAKLAKEELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKAR 382
            |...|:.....:.||:.|..:|.|||.|       .|||:.|.|.|.|:.....:|..::..
Zfish   254 EARREELLAEFDTEREQLGLRLRKEEAR-------CNALQEELETLGKETTDSVNGHHISMV--- 308

  Fly   383 QFSDDACATPPMVNIAKIVQPTATVSSMP--VSGPQTGIARSIAPGQNIRSAGIATAPTGTATAA 445
               :|| ..|.:::..    .|:..|..|  .:..|.||      .|...:|
Zfish   309 ---EDA-EKPSLLSNG----TTSQASQSPDIQAAYQAGI------HQRFHAA------------- 346

  Fly   446 IAPLTAVLNHTTTITTTTNNTTTSSNSNSSGSIGVAATAAAVAASVET-AATVTVPMVAPPSPSP 509
                    .|....|:..:....||..|....|....|:..:.:|.:. ..|:......|.|||
Zfish   347 --------RHKFQGTSDQDPNPVSSTINCPHDISPCPTSPDIISSKQAPRGTMLSRFSTPQSPS- 402

  Fly   510 AKMQPTATIQRAPGGKYAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAPPPIPTKPIVP 574
               :.|::.....|..|.|:..:..|..|         |..|  |:|.|. ||.|||||.|
Zfish   403 ---KSTSSNSSPFGTDYRAVVQSGMLSPT---------IRSP--TIPRAD-RGIPPPIPPK---- 448

  Fly   575 PKREPSLSRLGSITGSSAIAAATAATTAAGTAKQN 609
               :|.|:.  :....:.:.||..|....|..:.:
Zfish   449 ---KPGLAE--TPPSPATLRAAHFAHMTVGCGRNS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naus	NP_001286565.1	CortBP2	78..274	CDD:286770	67/205 (33%)
Naus	NP_001286565.1	Angiomotin_C	189..381	CDD:289044	68/191 (36%)
cttnbp2nla	XP_003198883.2	CortBP2	14..210	CDD:286770	66/203 (33%)
cttnbp2nla	XP_003198883.2	DUF342	<212..303	CDD:302792	31/97 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575134
Domainoid	1	1.000	102	1.000	Domainoid score	I6811
eggNOG	1	0.900	-	-		E1_KOG1103
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4704
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006973
OrthoInspector	1	1.000	-	-		otm24617
orthoMCL	1	0.900	-	-		OOG6_109427
Panther	1	1.100	-	-	O	PTHR23166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3610
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.780