Protein Alignment CG10914 and NOA1

DIOPT Version :9

• Sequence 1: NP_611297.3
• Gene: CG10914 / 37075
• FlyBaseID: FBgn0034307
• Length: 624
• Species: Drosophila melanogaster
• Sequence 2: NP_115689.1
• Gene: NOA1 / 84273
• HGNCID: 28473
• Length: 698
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 199/575 - (34%)
• Similarity: 310/575 - (53%)
• Gaps: 71/575 - (12%)

  Fly    96 GTPDPSLPASKVPCNGCGADLHCTNASLPGYIPSEIFRDRTQQE--LQTITCKRCHFLNHYNIAL 158
            |.|||:||.|.|.|:||||:|||.:|.:|||:|.|.|....:.:  |....|:||..|:|:..||
Human   128 GHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRAL 192

  Fly   159 DVVVAPSTYVDTISRI--QDKFALAIVLVDLLDFPCSIWPGMQNILGAKRPVFLVGNKVDLLPRD 221
            .:.|:...|::.:|..  :...:|.:.:|||||.|.::.|.:..::|.|: :.::||||||||:|
Human   193 RLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQ-LIVLGNKVDLLPQD 256

  Fly   222 SNIYLQHIKDSLQREFIKHG-------------------GGNGLN--------IKNVSLISAKTG 259
            :..|.|.:::.|..:..:.|                   .|...|        :::|.|||||||
Human   257 APGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTG 321

  Fly   260 YGIEELITQLHKTWAYKGDVYLVGCTNVGKSSLFNILLNSDYCRPEASDLVRKATTCPWPGTTLK 324
            ||:||||:.|.::|.|:|||||||.||.|||:|||.||.||||..:.|:.:.:||..|||||||.
Human   322 YGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLN 386

  Fly   325 LLRFPILRPSNDRVYQRFKRLVSERSEK----AEMEKERRAVARETGSAAAAQPVAPVGRTF--- 382
            ||:|||..|:..|:::|.:||..:.::.    :|.|:.:..|.::.|..     |..|||||
Human   387 LLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYV-----VGRVGRTFLYS 446

  Fly   383 -DRRENL---HDAFAMA---------GGSRPITTLNDRGKEYKEARWVYDTPGVMQPDQISPLLT 434
             ::::|:   .||.::|         |..:....:....::.|:|.|.|||||:.:.:.|..|||
Human   447 EEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLT 511

  Fly   435 AEELVKLQPATMIRPRAFRLRPQMSILLGGLARLDLLEITSPRKHFDWLKVFVFASEHLPIMIAD 499
            .:|:..:.|...|.||.|.|:|.|.:.||.:.|:|.|:    .....|..  |.||..||:.|..
Human   512 EKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQ----GNQSAWFT--VVASNILPVHITS 570

  Fly   500 TQEAESVYKRYVGSPFLGVPFASENLEARLRRWPGLQCKDGDIVLASEGRNEETRLNCDITLSSA 564
            ...|:::|:::.|...|.:|...:.   |:..:|.|..:|   ::..||......: .||..|||
Human   571 LDRADALYQKHAGHTLLQIPMGGKE---RMAGFPPLVAED---IMLKEGLGASEAV-ADIKFSSA 628

  Fly   565 GWMGILLPGHSECRLRAWTPKAAGIYRREPALIPLADRLVGKHIRYSLAYNTAKP 619
            ||:.:.........||.:||:...:..| |.|:|....:.|:.|:.|:||.|.||
Human   629 GWVSVTPNFKDRLHLRGYTPEGTVLTVR-PPLLPYIVNIKGQRIKKSVAYKTKKP 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	181/537 (34%)
		YqeH	145..332	CDD:206748	88/215 (41%)
NOA1	NP_115689.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..66
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..134		4/5 (80%)
		RbgA	139..660	CDD:331156	182/540 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..306		2/26 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140679
Domainoid	1	1.000	138	1.000	Domainoid score	I4871
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10518
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2557
Isobase	1	0.950	-	0	Normalized mean entropy	S5832
OMA	1	1.010	-	-		QHG49315
OrthoDB	1	1.010	-	-		D524165at33208
OrthoFinder	1	1.000	-	-		FOG0003459
OrthoInspector	1	1.000	-	-		oto91198
orthoMCL	1	0.900	-	-		OOG6_102331
Panther	1	1.100	-	-	LDO	PTHR46406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R779
SonicParanoid	1	1.000	-	-		X4448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750