DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10914 and noa1

DIOPT Version :9

Sequence 1:	NP_611297.3	Gene:	CG10914 / 37075	FlyBaseID:	FBgn0034307	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001107900.1	Gene:	noa1 / 564706	ZFINID:	ZDB-GENE-080220-18	Length:	702	Species:	Danio rerio

Alignment Length:	599	Identity:	208/599 - (34%)
Similarity:	320/599 - (53%)	Gaps:	40/599 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LARERYKDHEHVHYSSVLETKIKPSFSIPE--TQQHLPDDWMDD-YEFYQGAQEGGNKQ-GTPDP 100
            |.|:.:.|...|...|.....::....:.:  .::|...|:.|: :..::..::...|. |:||.
Zfish   103 LQRKHHDDDGEVRTQSKQLRGLERQLELMKGPVEEHSLIDFHDEGFPLHKPKKKRPQKVFGSPDA 167

  Fly   101 SLPASKVPCNGCGADLHCTNASLPGYIPSEIFRDRTQ-QELQTITCKRCHFLNHYNIALDVVVAP 164
            ....|:..|:||||.||||:...|||:|||.::...: ..|:...|:||..:.|...||.|.::|
Zfish   168 QAALSETSCSGCGALLHCTDPQEPGYLPSEKYKPLLEGGGLERAVCQRCFLIQHQQRALSVRMSP 232

  Fly   165 STYVDTISRIQDKFALAIVLVDLLDFPCSIWPGMQNILGAKRPVFLVGNKVDLLPRDSNIYLQHI 229
            ..|...:..|:...||.::::||||.|.||.|.:..:||..:.|.::||||||||.|:..|||.:
Zfish   233 DQYRAVVGSIRPLSALVLLILDLLDLPHSIIPDLPQLLGRNKRVVVLGNKVDLLPGDAQNYLQRV 297

  Fly   230 KDSLQREFIKHGGGNGLNIKNVSLISAKTGYGIEELITQLHKTWAYKGDVYLVGCTNVGKSSLFN 294
            :..|..:..:  .|...:.::|.|||||||||||.||:.|.....::|||||:|..|.|||:|||
Zfish   298 RRQLMADCAR--AGISADPRDVHLISAKTGYGIETLISSLQTRGRHRGDVYLIGMANAGKSTLFN 360

  Fly   295 ILLNSDYCRPEASDLVRKATTCPWPGTTLKLLRFPILRPSNDRVYQRFKRLVSERSEKAEMEKER 359
            .||.||||:..|:|.:.:||..|||||||.||:||||.|:..|:.:|     :||.::.:.....
Zfish   361 TLLESDYCKSTAADAIHRATISPWPGTTLNLLKFPILNPTAHRLSRR-----AERLQQTQQNITA 420

  Fly   360 RAVARETGSAAAAQPVAPVGRTF--------DRRENLHDAFAMAGG------SRPITTLNDRGKE 410
            ..:.|.|..:.....:..|||||        |..|...|:.:..|.      ..|.........|
Zfish   421 DELRRITHYSRHGYLIGHVGRTFQLKRAHSKDEVEFDADSLSFGGDLDGDVQKSPKADAELSYNE 485

  Fly   411 YKEARWVYDTPGVMQPDQISPLLTAEELVKLQPATMIRPRAFRLRPQMSILLGGLARLDLLEITS 475
            .|:|.|.|||||:::.:.:..:||.:|:..:.|...|.||.|.|:|...:.||||||:|.|:
Zfish   486 IKDAHWCYDTPGIIKENDLLSVLTEQEVKLVVPTVAITPRTFLLKPGTVLFLGGLARIDYLQ--- 547

  Fly   476 PRKHFDWLKVFVFASEHLPIMIADTQEAESVYKRYVGSPFLGVPFASENLEARLRRWPGLQCKDG 540
             .::..|..  |.||..:|:.|....:|:.:|:::.|:..||||...|.   |::.:|.|..:|.
Zfish   548 -GQNSCWFT--VLASSRVPVHITSLDKADDIYQKHAGNTLLGVPCGGEE---RMKTFPPLIAQDF 606

  Fly   541 DIVLASEGRNEETRLNCDITLSSAGWMGILLPGHSECRLRAWTPKAAGIYRREPALIPLADRLVG 605
            ::    :|::.:|.: .||.:|||||:.:......:..||...|.|||:..|.|.|:|...||.|
Zfish   607 EL----QGQDCDTAI-ADIKISSAGWIAVTADAGDQLLLRTRAPAAAGVCLRTPPLLPHIVRLKG 666

  Fly   606 KHIRYSLAYNTAKP 619
            :.|..|.||.|.||
Zfish   667 QRIHRSAAYKTRKP 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	183/501 (37%)
CG10914	NP_611297.3	YqeH	145..332	CDD:206748	87/186 (47%)
noa1	NP_001107900.1	PRK13796	176..653	CDD:237511	181/497 (36%)
noa1	NP_001107900.1	YqeH	213..398	CDD:206748	87/186 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573391
Domainoid	1	1.000	141	1.000	Domainoid score	I4672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10518
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2349
OMA	1	1.010	-	-		QHG49315
OrthoDB	1	1.010	-	-		D524165at33208
OrthoFinder	1	1.000	-	-		FOG0003459
OrthoInspector	1	1.000	-	-		oto40834
orthoMCL	1	0.900	-	-		OOG6_102331
Panther	1	1.100	-	-	LDO	PTHR46406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R779
SonicParanoid	1	1.000	-	-		X4448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940