DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10914 and Gnl2

DIOPT Version :9

Sequence 1:	NP_611297.3	Gene:	CG10914 / 37075	FlyBaseID:	FBgn0034307	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001020907.1	Gene:	Gnl2 / 362593	RGDID:	1305006	Length:	734	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	91/417 - (21%)
Similarity:	141/417 - (33%)	Gaps:	140/417 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 KRPVFLVGNKVDLLP------------RDSNIYLQHIKDSLQREFIKHGGGNGLNIKNVSLISAK 257
            |..:|:: ||.||:|            :|......|.  ||...|     |.|..|
  Rat   248 KHLIFVL-NKCDLVPTWATKRWVAVLSKDYPTLAFHA--SLTNPF-----GKGAFI--------- 295

  Fly   258 TGYGIEELITQLHKTWAYKGDVYL--VGCTNVGKSSLFNILLNSDYCR--PEASDLVRKATTCPW 318
                  :|:.|..|....|..:.:  :|..||||||:.|.|.:...|.  |.|.:      |..|
  Rat   296 ------QLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGE------TKVW 348

  Fly   319 PGTTLKLLRFPILRPSNDRVYQRFKRLVSERSE-----KAEMEKER-RAVARETGSAAAAQPVAP 377
            ...||....|.|..|.  .||.      ||.||     |..::.|: :|.....|:.........
  Rat   349 QYITLMRRIFLIDCPG--VVYP------SEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEY 405

  Fly   378 VGRTF--DRRENLHDAF---------AMAGGSRPITT-----LNDRGKEYKEARWVY-------D 419
            :.:|:  :..||..|..         .:.||...:.|     |||    ::..|..:       :
  Rat   406 ISKTYKIESWENAEDFLEKLALRTGKLLKGGEPDLLTVSKMVLND----WQRGRIPFFVKPPNAE 466

  Fly   420 TPGVMQPDQISPLLTAEELVKLQPA------------TMI--RPRAFRLRPQMSILLGGLARLDL 470
            .|...|....|||....|..:..|.            ::|  .|.|...:.:.|.:...|||:
  Rat   467 MPTTPQLPPSSPLEVTTETTQNNPEEETIETEVERSDSVIEKEPEAGCSQDENSEMQQILARV-- 529

  Fly   471 LEITSPRKHFDWLKV--------FVFASEHLPIMIADTQEAESVYKRYVGSPFLGVPFASENLEA 527
                  |::|..:.|        .|...:.:|:.::|.::.||                ||..|.
  Rat   530 ------RQNFGKINVGPQFSADDLVPVDDLVPVDLSDLEDLES----------------SEEEEE 572

  Fly   528 RLRRWPGLQCKDGDIVLASEGRNEETR 554
            :.:..||   :|     |.|..:.:||
  Rat   573 QEQEQPG---ED-----AEEECSRDTR 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	91/417 (22%)
CG10914	NP_611297.3	YqeH	145..332	CDD:206748	37/142 (26%)
Gnl2	NP_001020907.1	NGP1NT	44..174	CDD:285379
		RbgA	190..488	CDD:224083	65/280 (23%)
		NGP_1	209..365	CDD:206751	38/147 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900