DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10914 and gnl3

DIOPT Version :9

Sequence 1:	NP_611297.3	Gene:	CG10914 / 37075	FlyBaseID:	FBgn0034307	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001002297.1	Gene:	gnl3 / 321897	ZFINID:	ZDB-GENE-030131-616	Length:	561	Species:	Danio rerio

Alignment Length:	357	Identity:	73/357 - (20%)
Similarity:	125/357 - (35%)	Gaps:	108/357 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LPGYIP--SEIFRDRTQ--QELQTI--------------------------------TCKRCHFL 151
            :|...|  .|:.|:..|  |||:|:                                ..|:...:
Zfish    51 VPNSAPFKEEVLREAEQRKQELETLKEQNKIVKQQEKAAKRKKEKDAASSVKEPAAKKAKKAAKI 115

  Fly   152 NHYNIALDVVVAPSTY----VDTISRIQDKFALAIVLVDLLD----FPCSIWPGMQNIL----GA 204
            .....|:..|.:..|:    ::.:....|      |:|::||    ..|.. |.::.::    |.
Zfish   116 KEARAAIVKVKSAKTFKCQELNKVIEASD------VIVEVLDARDPLGCRC-PQLEEMVLKHEGK 173

  Fly   205 KRPVFLVGNKVDLLPRDSNI-----YLQ------------HIKDSLQREFIKHGGGNGLNIKNVS 252
            |:.:|:: ||:||:|:| |:     :|:            .:||...::..:..|.|.:    :.
Zfish   174 KKLLFIL-NKIDLVPKD-NLEKWLHFLEAECPTFLFKSSMQLKDRTVQQKRQQRGTNAV----LD 232

  Fly   253 LISAKTGYGIEELITQLHKTWAYK-GDVYL----VGCTNVGKSSLFNILLNSDYCRP-------- 304
            ...|.:.:|.:.|:..|:.....| |:..|    ||..||||||:.|.|.....|..
Zfish   233 HSRAASCFGKDFLLQTLNDLANKKEGETMLKVGVVGFPNVGKSSIINSLKEMRACNAGVQRGLTR 297

  Fly   305 --EASDLVRKATTCPWPGTTLKLLRFPILRPSNDRVYQRFKRLVSERSEKAEMEKERRAVARETG 367
              :...:.:|......||....|        ||.......:.|..|..|::..|..|..:.:...
Zfish   298 CMQEVHITKKVKMIDSPGILAAL--------SNPGSAMALRSLQVEEKEESPQEAVRNLLKQCNQ 354

  Fly   368 SAAAAQPVAPVGRTFDRRENLH--DAFAMAGG 397
            .....|...|     |.|.:|.  ..|||..|
Zfish   355 QHVMLQYNVP-----DYRSSLEFLTTFAMKHG 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	73/357 (20%)
CG10914	NP_611297.3	YqeH	145..332	CDD:206748	48/230 (21%)
gnl3	NP_001002297.1	GN3L_Grn1	17..85	CDD:285863	9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..58		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..110		0/33 (0%)
		GTPase_YlqF	128..411	CDD:274669	61/280 (22%)
		Nucleostemin_like	144..316	CDD:206753	42/184 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830