DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10914 and Gnl2

DIOPT Version :9

Sequence 1:	NP_611297.3	Gene:	CG10914 / 37075	FlyBaseID:	FBgn0034307	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_663527.2	Gene:	Gnl2 / 230737	MGIID:	2385207	Length:	728	Species:	Mus musculus

Alignment Length:	395	Identity:	88/395 - (22%)
Similarity:	140/395 - (35%)	Gaps:	108/395 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 RIQDKFALAIVLVDLLDFPCSIWPGMQNILGAKRP---VFLVGNKVDLLP------------RDS 222
            ::.|...:.:.::|..|...:..|.::..|..::|   :..|.||.||:|            :|.
Mouse   212 KVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDY 276

  Fly   223 NIYLQHIKDSLQREFIKHGGGNGLNIKNVSLISAKTGYGIEELITQLHKTWAYKGDVYL--VGCT 285
            .....|.  ||...|     |.|..|               :|:.|..|....|..:.:  :|..
Mouse   277 PTLAFHA--SLTNPF-----GKGAFI---------------QLLRQFGKLHTDKKQISVGFIGYP 319

  Fly   286 NVGKSSLFNILLNSDYCR--PEASDLVRKATTCPWPGTTLKLLRFPILRPSNDRVYQRFKRLVSE 348
            ||||||:.|.|.:...|.  |.|.:      |..|...||....|.|..|.  .||.      ||
Mouse   320 NVGKSSVINTLRSKKVCNVAPIAGE------TKVWQYITLMRRIFLIDCPG--VVYP------SE 370

  Fly   349 RSE-----KAEMEKER-RAVARETGSAAAAQPVAPVGRTF--DRRENLHDAF---------AMAG 396
            .||     |..::.|: :|.....|:.........:.:|:  :..||..|..         .:.|
Mouse   371 DSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKG 435

  Fly   397 GSRPITT-----LND--RGK---EYKEARWVYDTPGVMQPDQISPL--------------LTAEE 437
            |...:.|     |||  ||:   ..|.......|...:.|.  |||              .|..|
Mouse   436 GEPDMLTVSKMVLNDWQRGRIPFFVKPPNAELPTDSQLPPS--SPLEVPTETTQNNPEEETTETE 498

  Fly   438 LVKLQPATMIRPRAFRLRPQMSILLGGLARLDLLEITSPRKHFDWLKVF-VFASEHL-PIMIADT 500
            :.:....|...|.....:.:.|.:...|||:        |::|..:.|. .|:::.| |:.::|.
Mouse   499 VERSDSITEKEPEGDCSQDRNSEMQQILARV--------RQNFGKINVGPQFSADDLVPVEMSDL 555

  Fly   501 QEAES 505
            ::.||
Mouse   556 EDLES 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	88/395 (22%)
CG10914	NP_611297.3	YqeH	145..332	CDD:206748	42/177 (24%)
Gnl2	NP_663527.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		NGP1NT	43..174	CDD:400461
		NGP_1	209..365	CDD:206751	43/182 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..521		9/60 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..595		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900