DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10914 and noa1

DIOPT Version :9

Sequence 1:	NP_611297.3	Gene:	CG10914 / 37075	FlyBaseID:	FBgn0034307	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	XP_002937599.2	Gene:	noa1 / 100488516	XenbaseID:	XB-GENE-967857	Length:	693	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	227/647 - (35%)
Similarity:	328/647 - (50%)	Gaps:	102/647 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KDHEHVHYSSVLE----------TKIKPSFSIPETQQ---------------HLPDDWMDDYEFY 85
            ||.|.::...:||          ||..|..|....:|               |.||  :|:...:
Frog    68 KDTEDMYEKRLLEEYQKEKDLRTTKKDPHLSPALLKQVKTLHPFIEDLKRGNHKPD--LDEEVVF 130

  Fly    86 QGA------------QEGGNKQ------GTPDPSLPASKVPCNGCGADLHCTNASLPGYIPSEIF 132
            ..|            |:..|::      |.|||:||.|...|.||||.||....|||||:|||.:
Frog   131 TDADFTSVIKKLHFDQKDVNRKRQHKIYGNPDPNLPVSGEQCTGCGAVLHSLEPSLPGYLPSEKY 195

  Fly   133 RDRTQ-QELQTITCKRCHFLNHYNIALDVVVAPSTYVDTISRIQDKFALAIVLVDLLDFPCSIWP 196
            ....: ::...:.|:||..|.::..||.|.|:...|...:..||.|..|.:.:||:||.|.||:|
Frog   196 ASFLKCKDSNELMCQRCCLLIYHQKALHVKVSQEEYRSIVKSIQTKKGLVLFMVDMLDIPDSIFP 260

  Fly   197 GMQNILGAKRPVFLVGNKVDLLPRDSNIYLQHIKDSLQREFIKHGGGNGL-NIKNVSLISAKTGY 260
            .:.:|:|..:.:.::||||||||.||..||:::|..| .::....|.|.: ||.:|.|:||||||
Frog   261 DLIDIVGENKSILVLGNKVDLLPGDSPGYLKYLKGQL-HDYCTKAGLNWMGNITDVHLLSAKTGY 324

  Fly   261 GIEELITQLHKTWAYKGDVYLVGCTNVGKSSLFNILLNSDYCRPEASDLVRKATTCPWPGTTLKL 325
            |:||||::|.::|.|||||||||.||.|||:|||.||.||||:.:||:::::||..|||||||.|
Frog   325 GVEELISKLQQSWKYKGDVYLVGATNAGKSTLFNTLLQSDYCKEKASEIIKEATISPWPGTTLDL 389

  Fly   326 LRFPILRPSNDRVYQRFKRLVSERSEKAE------------MEKERRAVARETGSAAAAQPVAPV 378
            |:|||:.|...|::||.|||..:.|:..|            ::|....|.|...::..:|.::..
Frog   390 LKFPIVNPKPYRMFQRQKRLKEDFSKTEEDLSETELKQLKTLKKHSYVVGRVGRTSTKSQKMSKK 454

  Fly   379 GRTFDRR----------------ENLHDAFAMAGGSRPITTLNDRGKEYKEARWVYDTPGVMQPD 427
            ...||..                |||.:....        |.|    |.|:|.|.|||||:::..
Frog   455 DIEFDAELLSFSTEDDPEHGYLSENLREVNQF--------TYN----ELKDAHWFYDTPGIVKEG 507

  Fly   428 QISPLLTAEELVKLQPATMIRPRAFRLRPQMSILLGGLARLDLLEITSPRKHFDWLKVFVFASEH 492
            .:..||..:|:....|...|.||.|.|.|.|::.|..|.|:|.|:...|.    |..  |.||..
Frog   508 CVLNLLKDKEVKAALPTKAIIPRTFILSPGMTLFLAALGRIDFLQGERPA----WFS--VIASNL 566

  Fly   493 LPIMIADTQEAESVYKRYVGSPFLGVPFASENLEARLRRWPGLQCKDGDIVLASEGRNEETRLNC 557
            ||:.|....:|:.:|.::.|...||||...|.   |::.:|.|..:  ||.|...|   .:|...
Frog   567 LPVHITSLDKADDIYTKHAGGTLLGVPIGGEE---RMKEFPPLLPQ--DIKLKGIG---ASRAVA 623

  Fly   558 DITLSSAGWMGILLPGHSECRLRAWTPKAAGIYRREPALIPLADRLVGKHIRYSLAYNTAKP 619
            ||.||:|||:.:......:..||.:|||...:..|:|.|:||...:.|:.:|...||.|.||
Frog   624 DIKLSTAGWIAVTAHSGEQLHLRCFTPKGTSLTIRQPPLLPLVVNIKGERLRKGPAYATKKP 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10914	NP_611297.3	GTPase_YqeH	109..596	CDD:213834	193/516 (37%)
CG10914	NP_611297.3	YqeH	145..332	CDD:206748	95/187 (51%)
noa1	XP_002937599.2	PRK13796	172..659	CDD:237511	191/513 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10518
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2249
OMA	1	1.010	-	-		QHG49315
OrthoDB	1	1.010	-	-		D524165at33208
OrthoFinder	1	1.000	-	-		FOG0003459
OrthoInspector	1	1.000	-	-		oto104979
Panther	1	1.100	-	-	LDO	PTHR46406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R779
SonicParanoid	1	1.000	-	-		X4448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110