DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment adp and Dcaf8

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001344133.1	Gene:	Dcaf8 / 98193	MGIID:	91860	Length:	591	Species:	Mus musculus

Alignment Length:	599	Identity:	139/599 - (23%)
Similarity:	213/599 - (35%)	Gaps:	235/599 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRRRLLASPA-----------YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||.|.|.|.|           :|.|...:..|.||.||||.|.:...|.||||||||.:|::||.
Mouse   152 LRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDW 216

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153
            .|::.|....:.|..|||..||||.:.:|.:|.||.|..:.|.::     :...| |
Mouse   217 VRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAEL-----SATQC-CKNTKRVAQ 275

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |...:.:||...|||..|.|||||..:..:|:|:.   ||..    :|:...::.:......:.:
Mouse   276 HKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQD---RPAS----KLVVTKEKEKKVGLYTIYV 333

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283
            ||..|...|||..|.:.|:||:||:.....||:   :..:.|..:|.:.|:      ..||.|.:
Mouse   334 NPANTHQFAVGGRDQYVRIYDQRKIDENENNGV---LKKFCPHHLVNSESK------ANITCLVY 389

  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348
            :.:|||||.:...|.:|.|:.:|:
Mouse   390 SHDGTELLASYNDEDIYLFNSSHS----------------------------------------- 413

  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413

Mouse   414 ----------------------------------------------------------------- 413

  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478

Mouse   414 ----------------------------------------------------------------- 413

  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543
              ||.:|::                 ||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
Mouse   414 --DGAQYIK-----------------RYKGHRNNAT-VKGVNFYGPKSEFVVSGSDCGHIFLWEK 458

  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNL--VADVTRFVE 605
            .:.:|......| ..:|||::|||.:.:|||||:||::|||:|.|.::.|...|  |....:...
Mouse   459 SSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKEVIKKNKRER 523

  Fly   606 DNQEKMRLDPFELH 619
            |.......|.|:.|
Mouse   524 DEDSLHHTDLFDSH 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	67/195 (34%)
		WD40	59..>242	CDD:225201	65/190 (34%)
		WD40 repeat	72..108	CDD:293791	15/35 (43%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	16/44 (36%)
		WD40 repeat	214..268	CDD:293791	16/53 (30%)
		TPR_11	341..410	CDD:290150	0/68 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR_11	378..444	CDD:290150	0/65 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		TPR_6	415..445	CDD:289917	0/29 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<524..>584	CDD:225201	25/60 (42%)
		WD40	<526..584	CDD:295369	25/58 (43%)
Dcaf8	NP_001344133.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140
		2A1904	<17..177	CDD:273344	7/24 (29%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	40..51
		WD40	183..500	CDD:392136	121/529 (23%)
		WD 1	185..224		21/38 (55%)
		WD40 repeat	192..228	CDD:293791	15/35 (43%)
		WD 2	228..269		16/46 (35%)
		WD40 repeat	234..275	CDD:293791	13/46 (28%)
		WD 3	275..315		16/46 (35%)
		WD40 repeat	280..321	CDD:293791	16/47 (34%)
		WD 4	323..363		12/39 (31%)
		WD40 repeat	329..377	CDD:293791	15/50 (30%)
		WD 5	379..418		15/217 (7%)
		WD40 repeat	384..423	CDD:293791	16/228 (7%)
		WD 6	426..466		14/40 (35%)
		WD40 repeat	431..468	CDD:293791	12/36 (33%)
		WD 7	470..509		19/38 (50%)
		WD40 repeat	475..499	CDD:293791	14/23 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850