DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and COP1

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_010136.1	Gene:	COP1 / 851410	SGDID:	S000002304	Length:	1201	Species:	Saccharomyces cerevisiae

Alignment Length:	701	Identity:	131/701 - (18%)
Similarity:	236/701 - (33%)	Gaps:	204/701 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSDELYRVKYSSSRYQRQHTPLNASSLHWQRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGH 66
            |.||..|: :..|..:::|:....||...|.....:.||..|...::           :.:|.||
Yeast   156 SLDETIRI-WDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSLGDCVV-----------KFILEGH 208

  Fly    67 EGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRTK-HLGNVFSVKFLPKTNNSIVATC 130
            ...||...:......:.|||||.:|.:|.....|...|...: |..||.||.|.|..|  ::.:.
Yeast   209 TRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIFHPHQN--LIISV 271

  Fly   131 AADKFIYVYDINDPNETLFSCICHFSRAK-RLATAQDSPHV--FWSAGEDG-CILQLDIREPHRC 191
            ..||.:.|:|::....     :..|.|.. |.......||:  |.:|.:.| .:.:||...|  |
Yeast   272 GEDKTLRVWDLDKRTP-----VKQFKRENDRFWLIAAHPHINLFGAAHDSGIMVFKLDRERP--C 329

  Fly   192 RPEEGIGVRLLNLHDQLEN----------------------TEAKCLAINPRRTEYLAVGTNDPF 234
            .......:..:|...|:::                      ...:.::.||.:...|....|..|
Yeast   330 SFIHQNQLFFVNAEKQIQSFNFQKRVASLPYASLKGIGQPWDAFRSISYNPSQHSVLVNEANGKF 394

  Fly   235 ARV---------YDRRKLPSTNGN-----GLSACVAYYAPGQIVK------NISRNIVHEPRGIT 279
            |.|         .:...:....||     |.:..|.|....:.|:      .::|||..| ..:.
Yeast   395 ALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVYNKNTESVEVRSLENKVTRNIKVE-ETVR 458

  Fly   280 YLTFNGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLP-------------AFTSTLVHEEEPVKM 331
            .:...|.|:.|::             |....:.||:.             .:.|..:..:....|
Yeast   459 TIVAAGPGSVLVI-------------HPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQYVALM 510

  Fly   332 PHRSRSLPTE--------IEVYKKEGNDFLENGKLV-DAIDAYSAALAKYPQG------EVLYLN 381
            ...:.:|.|:        .|..:.:...:.|.|.|: ..::....:|....:|      :.||:.
Yeast   511 SKHTITLATKKLELINSMHETIRIKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKTLYIT 575

  Fly   382 RATALMRRGWFGDIYAALRDCH-EALRLDPSYVKAHFRLARALLELHRPQDADQCLQALIQRFPD 445
            :....:       :|...|:.. |.|.:||:    .:|..:||:.               :.||:
Yeast   576 KVQGKL-------VYCLNREGEIEILTIDPT----EYRFKKALVN---------------KNFPE 614

  Fly   446 FANNHGVLMLNKD---IKEN----RRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARDYM 503
                  ||.|.||   :.:|    .::|..||.          ..::::..:..:||   |.:|
Yeast   615 ------VLRLIKDSNLVGQNIISYLQKSGYPEI----------ALQFVQDPHIRFDL---ALEY- 659

  Fly   504 QRYVGHCNVTTD-IKEANYLGSQGEFIAAGSDDGN-------------------MYIWEGDTGKI 548
                |:.:|..| .|:.|...:....|......||                   :|:..||..|:
Yeast   660 ----GNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQTQHSFDKLSFLYLVTGDVNKL 720

  Fly   549 RAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVAD 599
                   |.:.|..|.......:..:...:|         |.:||.::.|:
Yeast   721 -------SKMQNIAQTREDFGSMLLNTFYNN---------STKERSSIFAE 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	47/223 (21%)
		WD40	59..>242	CDD:225201	47/218 (22%)
		WD40 repeat	72..108	CDD:293791	9/35 (26%)
		WD40 repeat	114..154	CDD:293791	9/39 (23%)
		WD40 repeat	158..203	CDD:293791	10/48 (21%)
		WD40 repeat	214..268	CDD:293791	13/73 (18%)
		TPR_11	341..410	CDD:290150	12/84 (14%)
		TPR repeat	342..370	CDD:276809	4/28 (14%)
		TPR repeat	375..408	CDD:276809	7/39 (18%)
		TPR_11	378..444	CDD:290150	11/66 (17%)
		TPR repeat	413..441	CDD:276809	3/27 (11%)
		TPR_6	415..445	CDD:289917	4/29 (14%)
		WD40 repeat	513..553	CDD:293791	10/59 (17%)
		WD40	<524..>584	CDD:225201	11/78 (14%)
		WD40	<526..584	CDD:295369	11/76 (14%)
COP1	NP_010136.1	WD40	17..322	CDD:238121	46/184 (25%)
		WD40 repeat	17..51	CDD:293791
		WD40 repeat	59..93	CDD:293791
		WD40 repeat	99..135	CDD:293791
		WD40 repeat	140..206	CDD:293791	12/61 (20%)
		WD40 repeat	213..250	CDD:293791	10/36 (28%)
		WD40 repeat	256..292	CDD:293791	10/42 (24%)
		Coatomer_WDAD	343..770	CDD:397941	80/493 (16%)
		COPI_C	829..1199	CDD:399736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000