DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and Dcaf6

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_036009808.1	Gene:	Dcaf6 / 74106	MGIID:	1921356	Length:	968	Species:	Mus musculus

Alignment Length:	935	Identity:	198/935 - (21%)
Similarity:	308/935 - (32%)	Gaps:	379/935 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LHW--QRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYR 90
            |.|  :::..|.|....||.|.|....::.||:.||.|..|:||||.:.|...|.::.|||||.:
Mouse    10 LLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTK 74

  Fly    91 VMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC--IC 153
            ::|.:|:.:|::..||:.|..|:||.||||.|::..:.:|:.|..|:..:|....||...|  .|
Mouse    75 LVISNPYSRKVLTTIRSGHRANIFSAKFLPCTDDKQIVSCSGDGVIFYTNIEQDAETNRQCQFTC 139

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |:.....:.|..:.|:.|.|.||||.:...|.|....|..|:.....|:|.     ...|..:||
Mouse   140 HYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINC-----RRAATSVAI 199

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPST-----NGNGLSACVAYYAPGQIVKNISRNIVHEPRGI 278
            .|....|||||.:|...|:||||.|.:.     .|.|.:..||.:.|..:.....|        :
Mouse   200 CPPVPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLSNKSCR--------V 256

  Fly   279 TYLTFNGNGTELLVNIGCEHVYRFDLNH------------------AEPPV-------------- 311
            |.|.::.:|.|:||:...:::|.||...                  .:|||
Mouse   257 TSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGP 321

  Fly   312 --------------------FYDLPAFTSTLVHEEEPVKMPHRSR---------------SLPT- 340
                                ...:....|....|...|...:|.|               :|||
Mouse   322 RARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRPRPRGGTNQPDVSTLPTV 386

  Fly   341 ----EIEVYK---------------KEGNDFLENGKLVDAIDA-YSAALAKYPQGEVL------- 378
                .:||.:               ....|.::......||:: .|::|...|..|..
Mouse   387 PSSPNLEVCETAMDVDMPAALLQPSTSSTDPVQAQAATAAIESPRSSSLLSCPDSEPRQSVEASG 451

  Fly   379 -YLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARA-------------------- 422
             :.:..:..:|    |...|.||...:.|||..:..:....||:|
Mouse   452 HHAHHQSEFLR----GPEIALLRKRLQQLRLKKAEQQRQQELAQAQHQPPTSTSDPPPHEGSSRD 512

  Fly   423 ----------------------------------------LLELH-------------------- 427
                                                    :|.||
Mouse   513 PRASDSPSSVVNKQLGSMSLDEQQDNSNERLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS 577

  Fly   428 -------------RPQDADQCL--QALIQ--------RFPDFANNHGVLM--------------- 454
                         :.:..::||  .:.:|        |.|:..:..|.|.
Mouse   578 STASSSRGNGSHCKSEGQEECLVPPSSVQPPEGDSETRAPEELSEKGTLPENLTQNQIDTAQLDN 642

  Fly   455 -------LNKDIKEN-------------------------------------------------- 462
                   .|...|.|
Mouse   643 FPAEPLDSNSGEKNNPSQDSPCGLPEEGTLSETDRETCEQASTESATRHASTKPELPSQTEAIEQ 707

  Fly   463 -------RRQSKSPEAPE----LQPV-------------EVDD---------GFRYLRLKNAEYD 494
                   |..|.:||.|.    :.|:             :.||         |.||.......::
Mouse   708 ASTESATRHTSANPELPSQTEAIAPLAHEDPSARDSALQDTDDSDDDPVLIPGARYRTGPGDRFN 772

  Fly   495 LRSTA--------------RDYMQR-----------------------YVGHCNVTTDIKEANYL 522
            :|.|.              :::.:|                       |.||.|..|.|||||:.
Mouse   773 IRGTTVGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFW 837

  Fly   523 GSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCA 587
            |:  .|:.:|||.|:::||:..|.:...:..||:.:|||:||||...:||:||||::||||||..
Mouse   838 GA--NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLE 900

  Fly   588 AS-------AEE---RPNLVADVTR 602
            .|       |:|   |..|:.:.||
Mouse   901 ESRIFNRKLADEVITRNELMLEETR 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	68/189 (36%)
		WD40	59..>242	CDD:225201	66/184 (36%)
		WD40 repeat	72..108	CDD:293791	12/35 (34%)
		WD40 repeat	114..154	CDD:293791	14/41 (34%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	20/58 (34%)
		TPR_11	341..410	CDD:290150	17/92 (18%)
		TPR repeat	342..370	CDD:276809	6/43 (14%)
		TPR repeat	375..408	CDD:276809	7/40 (18%)
		TPR_11	378..444	CDD:290150	18/176 (10%)
		TPR repeat	413..441	CDD:276809	8/122 (7%)
		TPR_6	415..445	CDD:289917	10/132 (8%)
		WD40 repeat	513..553	CDD:293791	15/39 (38%)
		WD40	<524..>584	CDD:225201	26/59 (44%)
		WD40	<526..584	CDD:295369	26/57 (46%)
Dcaf6	XP_036009808.1	WD40	43..>292	CDD:421866	83/261 (32%)
		WD40 repeat	55..92	CDD:293791	13/36 (36%)
		WD40 repeat	97..138	CDD:293791	14/40 (35%)
		WD40 repeat	148..181	CDD:293791	11/32 (34%)
		WD40 repeat	188..233	CDD:293791	17/49 (35%)
		WD40 repeat	256..282	CDD:293791	8/25 (32%)
		WD40	<838..897	CDD:421866	27/60 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55803
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820