DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and dcaf6

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_012819655.1	Gene:	dcaf6 / 733780	XenbaseID:	XB-GENE-5738809	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	766	Identity:	185/766 - (24%)
Similarity:	286/766 - (37%)	Gaps:	208/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSLHW--QRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDD 88
            |.|.|  :::..|....:::|...|....:|.||:.||.|..|:||||.:.|.:.|.::.|||||
Frog     6 SGLIWDVRKRSLGLSEPDVVRSNYLGRREFVQRLKLEATLNIHDGCVNSISWGSTGEYILSGSDD 70

  Fly    89 YRVMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC-- 151
            ..::|.:|:.||::..||:.|..|:||.||||.||:..:.:|:.|..|:..||....:|...|
Frog    71 TTLVITNPYNKKVLTRIRSGHRANIFSAKFLPLTNDKQIISCSGDGVIFFTDIEKDADTNRQCQF 135

  Fly   152 ICHFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCL 216
            .||:..|..:.|..:.|:.|.|.||||.:...|.|....|..|:.....|:|.     ...|..:
Frog   136 TCHYGTAYEIMTVPNDPYTFLSCGEDGTVRWFDTRTKTSCTKEDCKDDILINC-----RRAATSI 195

  Fly   217 AINPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYL 281
            ||.|....|||||.:|...|:||||.|.:...|..|   .....|..|:.:..::.::...:|.|
Frog   196 AICPTAPYYLAVGCSDSSVRIYDRRMLGTRATNNYS---NRGTTGMCVRFVPSHLTNKSCRVTSL 257

  Fly   282 TFNGNGTELLVNIGCEHVYRFDLNH------------------AEPPV----------------- 311
            .::.:|.|:||:...:::|.||..:                  .:|||
Frog   258 CYSEDGQEVLVSYSSDYIYLFDPKNDQAKELKLPSSDQKREEVRQPPVKRLRLRGDWSDTGPRAR 322

  Fly   312 --------------------FYDL----------------------------------------- 315
                                ..|:
Frog   323 PESERERDGDQSTNASLMQRMSDMLSRWFEEASEVAQSSRRRNRLQNRAGTSQPISSASLSTSHT 387

  Fly   316 -----PAFTSTLVHEEEP-----VKMPHRSRSLPTE-IEVY-KKEGNDFLENGKLVDAIDAYSAA 368
                 ..|.......|:|     |:..|...|:.|| :|.: ..:|.....:...|.:....|.:
Frog   388 ETQASETFPEVAASSEQPSSSSNVEESHSMTSIATEQLETFASSDGGSNPADSPSVISKQLGSMS 452

  Fly   369 LAKYPQGEVLYLNRATALMRRGWFGDI----YAALRDCHEALRLD-----------PSYVKAHFR 418
            |.: ||      .||.....|.....:    |:........::||           ...||....
Frog   453 LDE-PQ------ERAKVTSEREKNEPVLQLHYSTEGTTTSTIKLDFTDEWSNRSSSSVAVKVGNN 510

  Fly   419 LARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPEL--------- 474
            .:.|..||.:|.:.:...::..|......::.|  |..:...::.|.|.:...|:.
Frog   511 ESTATTELTQPSEMEDTSESTEQHVETTCSDPG--MEQESPGKSNRSSNNEGLPDTSVTAATSVS 573

  Fly   475 ---QPVEVDD----------GFRYLRLKNAEYDLRSTARDYMQR--------------------- 505
               |..:.||          ....|.:.......|.|.|....|
Frog   574 STHQETDSDDDTVRVPSRTQSQNRLSVGGPSVSTRLTRRTAAARIQELFRRRKERKELEEMDMQN 638

  Fly   506 ---------YVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNC 561
                     |.||.|..|.||||.:.|.  .|:.:|||.|:::||:..|.....:..||:.:|||
Frog   639 VHQPSSKIVYKGHRNSRTMIKEAAFWGK--NFVMSGSDCGHIFIWDRHTANHLMLLEADNHVVNC 701

  Fly   562 VQPHPSICMLATSGIDHNIKIWSPCAAS-------AEE---RPNLVADVTR 602
            :||||...:||:||||:|||||||....       |||   |..|:.:.||
Frog   702 LQPHPYDPILASSGIDYNIKIWSPLEQDKCFNWRLAEEVISRNELMLEETR 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	72/189 (38%)
		WD40	59..>242	CDD:225201	69/184 (38%)
		WD40 repeat	72..108	CDD:293791	13/35 (37%)
		WD40 repeat	114..154	CDD:293791	15/41 (37%)
		WD40 repeat	158..203	CDD:293791	14/44 (32%)
		WD40 repeat	214..268	CDD:293791	19/53 (36%)
		TPR_11	341..410	CDD:290150	14/85 (16%)
		TPR repeat	342..370	CDD:276809	4/28 (14%)
		TPR repeat	375..408	CDD:276809	4/36 (11%)
		TPR_11	378..444	CDD:290150	13/80 (16%)
		TPR repeat	413..441	CDD:276809	6/27 (22%)
		TPR_6	415..445	CDD:289917	5/29 (17%)
		WD40 repeat	513..553	CDD:293791	14/39 (36%)
		WD40	<524..>584	CDD:225201	27/59 (46%)
		WD40	<526..584	CDD:295369	27/57 (47%)
dcaf6	XP_012819655.1	WD40	41..>284	CDD:392136	84/250 (34%)
		WD40 repeat	53..90	CDD:293791	14/36 (39%)
		WD40 repeat	95..136	CDD:293791	15/40 (38%)
		WD40 repeat	146..179	CDD:293791	11/32 (34%)
		WD40 repeat	186..229	CDD:293791	17/47 (36%)
		WD40	<665..724	CDD:392136	28/60 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010