DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and wdtc1

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001124078.1	Gene:	wdtc1 / 570606	ZFINID:	ZDB-GENE-030131-3224	Length:	674	Species:	Danio rerio

Alignment Length:	641	Identity:	251/641 - (39%)
Similarity:	339/641 - (52%)	Gaps:	60/641 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LHWQRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVM 92
            ||.|.:: ...||  .:|....:..::.||..||.|.||.||||||||...|..|||||||...:
Zfish    17 LHRQIRE-NRALD--FQRHYHVTDPFIKRLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHAI 78

  Fly    93 IWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCICHFSR 157
            ||||||...:..:.|.|..|:|||||||.:::.|:.|.|||..::|:|:. ..||:.....|.:|
Zfish    79 IWDPFRHSKLITMHTGHAANIFSVKFLPHSDDRILITGAADTKVHVHDVT-AKETIHMFSDHTNR 142

  Fly   158 AKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAINPRR 222
            .||:|||...|:.||||.|||.|.|.|:||..:   ...:.:.|.....||  .||||||:|||.
Zfish   143 VKRIATAPMWPNTFWSAAEDGLIRQYDLRESSK---RSDVLIDLTEYCGQL--VEAKCLAVNPRD 202

  Fly   223 TEYLAVGTNDPFARVYD-------RRKLPSTNGNGL-----------SACVAYYAPGQI-VK--- 265
            ..|||||.|.||.|:||       |:.|..::..|:           .....||..|.: ||
Zfish   203 NNYLAVGANGPFVRLYDIRMIHNHRKSLSQSSSAGVHTFCDKRKSIPDGAGQYYVAGHLPVKLPD 267

  Fly   266 --NISRNIVHEPRGITYLTFNGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLP--AFTSTLVHE- 325
              |..|.:|     .||:||:.:|||||||:|.|.||.|||...:.|..:.||  ..:||.|..
Zfish   268 YNNRLRVLV-----ATYVTFSPDGTELLVNMGGEQVYLFDLTFKQRPYTFLLPKKCHSSTDVQNG 327

  Fly   326 ------EEPVKMP-----------HRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAKYP 373
                  ...:.:|           ..|..||..:|..|:..||.....:...||..||..:.:..
Zfish   328 KTTNGVSNGIHLPASRLKLAKVSSSGSGDLPLHLERIKQRANDAFARQQWTQAIQLYSLGIHEAG 392

  Fly   374 QGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCLQA 438
            ...:||.|||.|.|:|.|.||.|.|||||.:||.|:|.::||||||||.|.||....:|.:||..
Zfish   393 PNAMLYGNRAAAYMKRKWDGDHYDALRDCLKALSLNPGHLKAHFRLARCLFELKYVAEALECLND 457

  Fly   439 LIQRFPDFANNHGVLMLNKDIKEN--RRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARD 501
            ...:||:.|::.....|:||||..  .:...|.:......:...:..|...:...|..||..:.|
Zfish   458 FKGKFPEQAHSSACDALDKDIKAALFSKTDASDDKKGNSSIRFHNFSRKESIPEDEIVLRERSFD 522

  Fly   502 YMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNCVQPHP 566
            |..||.||||.||||||||:.||:|::|.:|||||:.:|||.:|..:..:.:.|.:||||:||||
Zfish   523 YKHRYCGHCNTTTDIKEANFFGSKGQYIVSGSDDGSFFIWEKETTNLVRILQGDESIVNCLQPHP 587

  Fly   567 SICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELHTRN 622
            ..|.|||||||..:::|||......|...:|.|:....:.||.:|..||.|:...|
Zfish   588 GHCFLATSGIDPVVRLWSPRPECENENGRVVEDMEGAAQANQRRMNADPLEVMLLN 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	92/194 (47%)
		WD40	59..>242	CDD:225201	90/189 (48%)
		WD40 repeat	72..108	CDD:293791	18/35 (51%)
		WD40 repeat	114..154	CDD:293791	16/39 (41%)
		WD40 repeat	158..203	CDD:293791	19/44 (43%)
		WD40 repeat	214..268	CDD:293791	27/77 (35%)
		TPR_11	341..410	CDD:290150	28/68 (41%)
		TPR repeat	342..370	CDD:276809	8/27 (30%)
		TPR repeat	375..408	CDD:276809	19/32 (59%)
		TPR_11	378..444	CDD:290150	35/65 (54%)
		TPR repeat	413..441	CDD:276809	14/27 (52%)
		TPR_6	415..445	CDD:289917	14/29 (48%)
		WD40 repeat	513..553	CDD:293791	21/39 (54%)
		WD40	<524..>584	CDD:225201	29/59 (49%)
		WD40	<526..584	CDD:295369	28/57 (49%)
wdtc1	NP_001124078.1	WD40	<45..169	CDD:295369	63/124 (51%)
		WD40	48..>324	CDD:225201	121/286 (42%)
		WD40 repeat	57..93	CDD:293791	19/35 (54%)
		WD40 repeat	99..137	CDD:293791	16/38 (42%)
		WD40 repeat	143..184	CDD:293791	18/43 (42%)
		WD40 repeat	191..218	CDD:293791	18/26 (69%)
		WD40 repeat	238..277	CDD:293791	8/43 (19%)
		WD40 repeat	278..315	CDD:293791	19/36 (53%)
		TPR_11	365..429	CDD:290150	27/63 (43%)
		TPR repeat	365..389	CDD:276809	7/23 (30%)
		TPR repeat	394..427	CDD:276809	19/32 (59%)
		TPR_1	395..431	CDD:278916	21/35 (60%)
		TPR_16	401..466	CDD:290168	34/64 (53%)
		TPR repeat	432..456	CDD:276809	13/23 (57%)
		WD40	522..>605	CDD:295369	46/82 (56%)
		WD40 repeat	534..574	CDD:293791	21/39 (54%)
		WD40	<541..>605	CDD:225201	31/63 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580149
Domainoid	1	1.000	164	1.000	Domainoid score	I3910
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8997
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1883
OMA	1	1.010	-	-		QHG55803
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0005181
OrthoInspector	1	1.000	-	-		oto39722
orthoMCL	1	0.900	-	-		OOG6_104422
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	1	1.000	-	-		X4797
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800