DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and dcaf6

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_005167897.1	Gene:	dcaf6 / 564498	ZFINID:	ZDB-GENE-090206-2	Length:	988	Species:	Danio rerio

Alignment Length:	943	Identity:	187/943 - (19%)
Similarity:	279/943 - (29%)	Gaps:	402/943 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRT 107
            :|...|....:|.||:.||||..|:||||.:.|...|.::.|||||..::|.:|:.:|:...||:
Zfish    24 IRTNYLGRREFVQRLKLEAVLNVHDGCVNTISWNDTGEYILSGSDDTNLVITNPYNRKVKTTIRS 88

  Fly   108 KHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC--ICHFSRAKRLATAQDSPHV 170
            .|..|:||.||:|.||:..:.:|:.|..|:........|....|  .||:..|..:.|..:.|:.
Zfish    89 GHRANIFSAKFMPHTNDQQIVSCSGDGIIFYTHTEKSQEINRQCQFTCHYGTAYEIMTVPNDPYT 153

  Fly   171 FWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTEYLAVGTNDPFA 235
            |.|.||||.:...|:|....|..|:.....|:|.     ...|..::|.|....|||||.:|...
Zfish   154 FLSCGEDGTVRWFDLRMKTSCTKEDCKDDILINC-----RRAATSISICPLVPYYLAVGCSDSSV 213

  Fly   236 RVYDRRKLPST-----NGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTELLVNIG 295
            |:||||.|.:.     .|.|.:.....:.|..:.....|        :|.|.::.:|.|:||:..
Zfish   214 RIYDRRMLGTRATGNYMGRGTTGMCVRFVPAHLSTKSCR--------VTSLCYSEDGQEVLVSYS 270

  Fly   296 CEHVYRFDLNH-----------------AEPPV--------FYDL-PAFTSTLVHEEEPVKMPH- 333
            .:::|.||...                 .:|||        :.|. |........|.:..:.|:
Zfish   271 SDYIYLFDPKDDQARELKGPSEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNV 335

  Fly   334 -----------------------------RSRSLPTEIEVYKKE--GNDFLENGKLVDAI----- 362
                                         |.|....:.|....|  ....:.:|...:.:
Zfish   336 SLMQRMSDMLSRWFEEASEAQSSRARPQTRPRGTAAQAEGTSSETTAQAQVSSGVAAEGVMELET 400

  Fly   363 ----------------------------------------------DAYSAALAKYP------QG 375
                                                          .|.|::|...|      ||
Zfish   401 PTINPLPTPPAPAPPSEPLPKSVSSSSSGSSSTVTAPPPSSSSSMESATSSSLLSSPDTEQKSQG 465

  Fly   376 EVLYLNRATALMRRGWFGDIYAALRD-----------CHEALRL----DP--------------- 410
            ||.....||............|||.:           |....||    ||
Zfish   466 EVTPTPSATPTPSATPTASREAALSEYGPHRLPVSLVCRRLQRLLLLSDPPGQGRRTMPNVPMTS 530

  Fly   411 -----------------SYVKAHFR---------------------------------------- 418
                             |.|....|
Zfish   531 SSESSAQQATAAADSPSSVVNKQLRSMTLEEEQGVKSSGEAAVRVIGDQSTGVTEASPETTESVP 595

  Fly   419 --------------------------LARALLELHRPQDADQCLQALIQRFPDFAN--------- 448
                                      .|..:|.||...:........:    ||.:
Zfish   596 STSAPSLGTSPGNISVSTPSGSGRSGTAEPVLSLHYSTEGTTTSTIKL----DFTDEWSSPASGA 656

  Fly   449 -------NHGVLMLNKDIKE--------------------------------NRRQSKSPEAPEL 474
                   ..|.|..::..:|                                ::..|.|..||..
Zfish   657 KSSSGGQKSGELEESQSREEPPGHKSSSSSKSEPTPDGGQTASSSTEKPGISSKNSSASAPAPPG 721

  Fly   475 QPVEVDDGF-----------------------------------------------------RYL 486
            .|...|.|.                                                     ||.
Zfish   722 DPSTTDTGHPSEELQTAASEQLSEQCRTSENAGTASQGSTQPSRNNQDSDDSDDDPILIPSARYR 786

  Fly   487 RLKNAEYDLRSTA-RDYMQR------------------------------------YVGHCNVTT 514
            ..:...:..|.:| .|.|.|                                    |.||.|..|
Zfish   787 GGQGQRFSYRGSAVGDRMIRRSAAARIQELFRRRKERREMEESETQNIRRPSVKMMYKGHRNSRT 851

  Fly   515 DIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHN 579
            .|||:.:.||  .|:.:|||.|:::||:..||:...:..||:.:|||:||||...:||:||||::
Zfish   852 MIKESCFWGS--NFVMSGSDCGHIFIWDRHTGEHLMLLEADNHVVNCLQPHPYDPILASSGIDYD 914

  Fly   580 IKIWSPCAAS-------AEE---RPNLVADVTR 602
            ||:|||...|       |:|   |..|:.:.||
Zfish   915 IKLWSPLEQSPSFNRVLADEVIARNELMLEETR 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	68/189 (36%)
		WD40	59..>242	CDD:225201	65/184 (35%)
		WD40 repeat	72..108	CDD:293791	12/35 (34%)
		WD40 repeat	114..154	CDD:293791	12/41 (29%)
		WD40 repeat	158..203	CDD:293791	14/44 (32%)
		WD40 repeat	214..268	CDD:293791	17/58 (29%)
		TPR_11	341..410	CDD:290150	19/142 (13%)
		TPR repeat	342..370	CDD:276809	5/80 (6%)
		TPR repeat	375..408	CDD:276809	9/43 (21%)
		TPR_11	378..444	CDD:290150	17/178 (10%)
		TPR repeat	413..441	CDD:276809	6/93 (6%)
		TPR_6	415..445	CDD:289917	5/95 (5%)
		WD40 repeat	513..553	CDD:293791	15/39 (38%)
		WD40	<524..>584	CDD:225201	27/59 (46%)
		WD40	<526..584	CDD:295369	26/57 (46%)
dcaf6	XP_005167897.1	WD40	<39..>284	CDD:225201	80/257 (31%)
		WD40	40..>283	CDD:295369	80/255 (31%)
		WD40 repeat	52..89	CDD:293791	13/36 (36%)
		WD40 repeat	94..135	CDD:293791	12/40 (30%)
		WD40 repeat	145..178	CDD:293791	11/32 (34%)
		WD40 repeat	185..230	CDD:293791	16/49 (33%)
		WD40 repeat	253..279	CDD:293791	8/25 (32%)
		WD40	<833..919	CDD:295369	36/87 (41%)
		WD40	<833..>919	CDD:225201	36/87 (41%)
		WD40 repeat	894..920	CDD:293791	16/25 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55803
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930