DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and DCAF6

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001185885.1	Gene:	DCAF6 / 55827	HGNCID:	30002	Length:	951	Species:	Homo sapiens

Alignment Length:	918	Identity:	195/918 - (21%)
Similarity:	301/918 - (32%)	Gaps:	362/918 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LHW--QRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYR 90
            |.|  :::..|.|....||.|.|....::.||:.||.|..|:||||.:.|...|.::.|||||.:
Human    10 LLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTK 74

  Fly    91 VMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC--IC 153
            ::|.:|:.:|::..||:.|..|:||.||||.||:..:.:|:.|..|:..::....||...|  .|
Human    75 LVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTC 139

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |:.....:.|..:.|:.|.|.||||.:...|.|....|..|:.....|:|.     ...|..:||
Human   140 HYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINC-----RRAATSVAI 199

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPST-----NGNGLSACVAYYAPGQIVKNISRNIVHEPRGI 278
            .|....|||||.:|...|:||||.|.:.     .|.|.:..||.:.|..:.....|        :
Human   200 CPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCR--------V 256

  Fly   279 TYLTFNGNGTELLVNIGCEHVYRFDLNH------------------AEPPV-------------- 311
            |.|.::.:|.|:||:...:::|.||...                  .:|||
Human   257 TSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGP 321

  Fly   312 --------------------FYDLPAFTSTLVHEEEPVKMPHRSR---------------SLPT- 340
                                ...:....|....|...|...:|.|               :|||
Human   322 RARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTV 386

  Fly   341 ----EIEVYK------KEGNDFLE-----------NGKLVDAIDAYSAALAKYPQGEVL------ 378
                ::||.:      .....||:           :.........:|..|...|..|..
Human   387 PSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEAS 451

  Fly   379 --YLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLA--------------------- 420
              :.:..:..:|    |...|.||...:.|||..:..:....||
Human   452 GHHTHHQSEFLR----GPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQD 512

  Fly   421 --------------------------------------RALLELH-------------------- 427
                                                  ..:|.||
Human   513 PHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS 577

  Fly   428 ----------------------------RPQDADQCLQALIQRFPDF------------ANNH-G 451
                                        :|.:.|...:|..:...|.            ..|| .
Human   578 SIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHIN 642

  Fly   452 VLMLNK--------------DIKENR-----------RQSKSPEA----------------PE-- 473
            :...:|              |:..:|           .::|.||.                ||
Human   643 ITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQ 707

  Fly   474 --------------------LQPVEVDD-------GFRYLRLKNAEYDLRSTA------------ 499
                                ||..:..|       |.||.......:::|.|.
Human   708 FQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVA 772

  Fly   500 --RDYMQR-----------------------YVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMY 539
              :::.:|                       |.||.|..|.|||||:.|:  .|:.:|||.|:::
Human   773 RIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGA--NFVMSGSDCGHIF 835

  Fly   540 IWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCAAS-------AEE---RP 594
            ||:..|.:...:..||:.:|||:||||...:||:||||::||||||...|       |:|   |.
Human   836 IWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRN 900

  Fly   595 NLVADVTR 602
            .|:.:.||
Human   901 ELMLEETR 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	68/189 (36%)
		WD40	59..>242	CDD:225201	66/184 (36%)
		WD40 repeat	72..108	CDD:293791	12/35 (34%)
		WD40 repeat	114..154	CDD:293791	14/41 (34%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	20/58 (34%)
		TPR_11	341..410	CDD:290150	16/93 (17%)
		TPR repeat	342..370	CDD:276809	5/44 (11%)
		TPR repeat	375..408	CDD:276809	7/40 (18%)
		TPR_11	378..444	CDD:290150	16/180 (9%)
		TPR repeat	413..441	CDD:276809	8/134 (6%)
		TPR_6	415..445	CDD:289917	8/136 (6%)
		WD40 repeat	513..553	CDD:293791	15/39 (38%)
		WD40	<524..>584	CDD:225201	26/59 (44%)
		WD40	<526..584	CDD:295369	26/57 (46%)
DCAF6	NP_001185885.1	WD40	<42..>281	CDD:225201	81/251 (32%)
		WD40	43..>292	CDD:295369	83/261 (32%)
		WD 1	49..88		15/38 (39%)
		WD40 repeat	55..92	CDD:293791	13/36 (36%)
		WD 2	92..133		15/40 (38%)
		WD40 repeat	97..138	CDD:293791	14/40 (35%)
		WD 3	139..179		13/39 (33%)
		WD40 repeat	148..181	CDD:293791	11/32 (34%)
		WD40 repeat	188..233	CDD:293791	17/49 (35%)
		WD 4	189..229		17/44 (39%)
		WD 5	251..290		10/46 (22%)
		WD40 repeat	256..282	CDD:293791	8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..340		3/51 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..392		7/36 (19%)
		WD40	<821..880	CDD:295369	27/60 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55803
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830