DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and dcaf8

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001016610.1	Gene:	dcaf8 / 549364	XenbaseID:	XB-GENE-989771	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	137/599 - (22%)
Similarity:	211/599 - (35%)	Gaps:	235/599 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRRRLLASP-----------AYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||:|.:.|.           .:|.|......|.||.||||.|.:...|.||||||||.:|::||.
Frog   164 LRQRQMGSSTRFIYDACGARGFVQRFRLLHGLDGHSGCVNTLHFNQRGTWLASGSDDLKVVVWDW 228

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153
            .|:|.|....:.|..|||..||||.:.:|.:|.||.|..:.|.:::..:     | |
Frog   229 VRRKPVLEFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAELSATH-----C-CKNTKRVAQ 287

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |...:.:||..:|||..|.|||||..:..:|:|:.   ||..    ||:...::.:......:.:
Frog   288 HKGASHKLALERDSPCTFLSAGEDAVVFTIDLRQD---RPAS----RLVVTKEKEKKVGLYTIYV 345

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283
            ||..|...|||..|.|.|:||:||:.....||:   :..:.|..:|.:.::      ..||.|.:
Frog   346 NPANTYQFAVGGRDQFVRIYDQRKINENVNNGV---LKKFCPHHLVTSEAK------ANITCLVY 401

  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348
            :.:|:|||.:...|.:|.|:.:|:
Frog   402 SHDGSELLASYNDEDIYLFNSSHS----------------------------------------- 425

  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413

Frog   426 ----------------------------------------------------------------- 425

  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478

Frog   426 ----------------------------------------------------------------- 425

  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543
              ||                 .:|::||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
Frog   426 --DG-----------------AEYIKRYKGHRNNAT-VKGVNFYGPRSEFVVSGSDCGHIFLWEK 470

  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNL--VADVTRFVE 605
            .:.:|......| ..:|||::|||.:.:|||||:|:::|||.|.|....|...|  |....:...
Frog   471 SSCQIVQFMDGDKGGVVNCLEPHPHLPVLATSGLDYDVKIWLPTAKEPTELNGLKEVIKKNKRER 535

  Fly   606 DNQEKMRLDPFELH 619
            |.......|.|:.|
Frog   536 DEDSLHHTDLFDNH 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	70/195 (36%)
		WD40	59..>242	CDD:225201	68/190 (36%)
		WD40 repeat	72..108	CDD:293791	16/35 (46%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	17/44 (39%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		TPR_11	341..410	CDD:290150	0/68 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR_11	378..444	CDD:290150	0/65 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		TPR_6	415..445	CDD:289917	0/29 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<524..>584	CDD:225201	24/60 (40%)
		WD40	<526..584	CDD:295369	24/58 (41%)
dcaf8	NP_001016610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..141
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	39..50
		WD40	191..511	CDD:421866	120/532 (23%)
		WD 1	197..236		22/38 (58%)
		WD40 repeat	204..240	CDD:293791	16/35 (46%)
		WD 2	240..281		16/46 (35%)
		WD40 repeat	246..287	CDD:293791	13/46 (28%)
		WD 3	287..327		16/46 (35%)
		WD40 repeat	292..333	CDD:293791	17/47 (36%)
		WD 4	335..375		13/39 (33%)
		WD40 repeat	341..389	CDD:293791	16/50 (32%)
		WD 5	391..430		13/234 (6%)
		WD40 repeat	396..435	CDD:293791	15/228 (7%)
		WD 6	438..478		14/40 (35%)
		WD40 repeat	443..480	CDD:293791	12/36 (33%)
		WD 7	482..522		19/39 (49%)
		WD40 repeat	487..511	CDD:293791	13/23 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950