Protein Alignment adp and dcaf8

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_001016610.1
• Gene: dcaf8 / 549364
• XenbaseID: XB-GENE-989771
• Length: 604
• Species: Xenopus tropicalis
• Alignment Length: 599
• Identity: 137/599 - (22%)
• Similarity: 211/599 - (35%)
• Gaps: 235/599 - (39%)

  Fly    43 LRRRLLASP-----------AYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||:|.:.|.           .:|.|......|.||.||||.|.:...|.||||||||.:|::||.
 Frog   164 LRQRQMGSSTRFIYDACGARGFVQRFRLLHGLDGHSGCVNTLHFNQRGTWLASGSDDLKVVVWDW 228

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153
            .|:|.|....:.|..|||..||||.:.:|.:|.||.|..:.|.:::..:     | |
 Frog   229 VRRKPVLEFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAELSATH-----C-CKNTKRVAQ 287

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |...:.:||..:|||..|.|||||..:..:|:|:.   ||..    ||:...::.:......:.:
 Frog   288 HKGASHKLALERDSPCTFLSAGEDAVVFTIDLRQD---RPAS----RLVVTKEKEKKVGLYTIYV 345

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283
            ||..|...|||..|.|.|:||:||:.....||:   :..:.|..:|.:.::      ..||.|.:
 Frog   346 NPANTYQFAVGGRDQFVRIYDQRKINENVNNGV---LKKFCPHHLVTSEAK------ANITCLVY 401

  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348
            :.:|:|||.:...|.:|.|:.:|:
 Frog   402 SHDGSELLASYNDEDIYLFNSSHS----------------------------------------- 425

  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543
              ||                 .:|::||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
 Frog   426 --DG-----------------AEYIKRYKGHRNNAT-VKGVNFYGPRSEFVVSGSDCGHIFLWEK 470

  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNL--VADVTRFVE 605
            .:.:|......| ..:|||::|||.:.:|||||:|:::|||.|.|....|...|  |....:...
 Frog   471 SSCQIVQFMDGDKGGVVNCLEPHPHLPVLATSGLDYDVKIWLPTAKEPTELNGLKEVIKKNKRER 535

  Fly   606 DNQEKMRLDPFELH 619
            |.......|.|:.|
 Frog   536 DEDSLHHTDLFDNH 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	70/195 (36%)
		WD40 repeat	72..108	CDD:293791	16/35 (46%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	17/44 (39%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		Spy	338..>461	CDD:443119	0/122 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<526..584	CDD:475233	24/58 (41%)
dcaf8	NP_001016610.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..141
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q5TAQ9	39..50
		WD40	<190..511	CDD:441893	120/533 (23%)
		WD 1	197..236		22/38 (58%)
		WD40 repeat	204..240	CDD:293791	16/35 (46%)
		WD 2	240..281		16/46 (35%)
		WD40 repeat	246..287	CDD:293791	13/46 (28%)
		WD 3	287..327		16/46 (35%)
		WD40 repeat	292..333	CDD:293791	17/47 (36%)
		WD 4	335..375		13/39 (33%)
		WD40 repeat	341..389	CDD:293791	16/50 (32%)
		WD 5	391..430		13/234 (6%)
		WD40 repeat	396..435	CDD:293791	15/228 (7%)
		WD 6	438..478		14/40 (35%)
		WD40 repeat	443..480	CDD:293791	12/36 (33%)
		WD 7	482..522		19/39 (49%)
		WD40 repeat	487..511	CDD:293791	13/23 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..604