DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and DCAF8

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_056541.2	Gene:	DCAF8 / 50717	HGNCID:	24891	Length:	597	Species:	Homo sapiens

Alignment Length:	602	Identity:	141/602 - (23%)
Similarity:	216/602 - (35%)	Gaps:	239/602 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRRRLLASPA-----------YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||.|.|.|.|           :|.|...:..|.||.||||.|.:...|.||||||||.:|::||.
Human   158 LRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDW 222

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153
            .|::.|....:.|..|||..||||.:.:|.:|.||.|..:.|.::     :...| |
Human   223 VRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAEL-----SATQC-CKNTKRVAQ 281

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |...:.:||...|||..|.|||||..:..:|:|:.   ||..    :|:...::.:......:.:
Human   282 HKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQD---RPAS----KLVVTKEKEKKVGLYTIYV 339

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283
            ||..|...|||..|.|.|:||:||:.....||:   :..:.|..:|.:.|:      ..||.|.:
Human   340 NPANTHQFAVGGRDQFVRIYDQRKIDENENNGV---LKKFCPHHLVNSESK------ANITCLVY 395

  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348
            :.:|||||.:...|.:|.|:.:|:
Human   396 SHDGTELLASYNDEDIYLFNSSHS----------------------------------------- 419

  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413

Human   420 ----------------------------------------------------------------- 419

  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478

Human   420 ----------------------------------------------------------------- 419

  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543
              ||.:|::                 ||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
Human   420 --DGAQYVK-----------------RYKGHRNNAT-VKGVNFYGPKSEFVVSGSDCGHIFLWEK 464

  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDN 607
            .:.:|......| ..:|||::|||.:.:|||||:||::|||:|.|.::.|...| .||.:
Human   465 SSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGL-KDVIK----- 523

  Fly   608 QEKMRLDPFELHTRNAY 624
            :.|...|...||..:.:
Human   524 KNKRERDEDSLHQTDLF 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	68/195 (35%)
		WD40	59..>242	CDD:225201	66/190 (35%)
		WD40 repeat	72..108	CDD:293791	15/35 (43%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	16/44 (36%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		TPR_11	341..410	CDD:290150	0/68 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR_11	378..444	CDD:290150	0/65 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		TPR_6	415..445	CDD:289917	0/29 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<524..>584	CDD:225201	25/60 (42%)
		WD40	<526..584	CDD:295369	25/58 (43%)
DCAF8	NP_056541.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..147
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:22500989	39..50
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22500989	114..122
		WD40	189..506	CDD:392136	122/529 (23%)
		WD 1	191..230		21/38 (55%)
		WD40 repeat	198..234	CDD:293791	15/35 (43%)
		WD 2	234..275		16/46 (35%)
		WD40 repeat	240..281	CDD:293791	13/46 (28%)
		WD 3	281..321		16/46 (35%)
		WD40 repeat	286..327	CDD:293791	16/47 (34%)
		WD 4	329..369		13/39 (33%)
		WD40 repeat	335..383	CDD:293791	16/50 (32%)
		WD 5	385..424		15/217 (7%)
		WD40 repeat	390..429	CDD:293791	16/228 (7%)
		WD 6	432..472		14/40 (35%)
		WD40 repeat	437..474	CDD:293791	12/36 (33%)
		WD 7	476..515		19/38 (50%)
		WD40 repeat	481..505	CDD:293791	14/23 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..597
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950