DRSC/TRiP Functional Genomics Resources

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Protein Alignment adp and DCAF8L2

DIOPT Version :9

Sequence 1:NP_001286563.1 Gene:adp / 37073 FlyBaseID:FBgn0000057 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_001340377.1 Gene:DCAF8L2 / 347442 HGNCID:31811 Length:631 Species:Homo sapiens


Alignment Length:625 Identity:133/625 - (21%)
Similarity:214/625 - (34%) Gaps:253/625 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 QQYGHELDEML-----------------------RRRLLASP----------AYVDRLEQEAVLV 64
            :||..|.|:.|                       :|:|.:.|          |:|.|...:..|.
Human   161 EQYSLEEDQALEEWVSSETSALPRPRWQVVTALHQRQLGSRPRFVYEACGARAFVQRFRLQYRLA 225

  Fly    65 GHEGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVAT 129
            .|.||||.:.:...|..|||..||.:|::||..|::.|....:.|..|||..||||...:|.:|.
Human   226 DHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFESGHTNNVFQAKFLPNCGDSTLAM 290

  Fly   130 CAADKFIYVYDINDPNETLFS---CIC-HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHR 190
            ||.|..:.|.::  .|.:.|:   |:. |...|.:||...|||:.|.::|||..:..:|:|:.  
Human   291 CARDGQVRVAEL--INASYFNNTKCVAQHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQD-- 351

  Fly   191 CRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACV 255
             ||...:.|    ..:..:......:.:||..|...|||..|.|.|:||:||:.....||:   :
Human   352 -RPASKVVV----TRENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRKIDKKENNGV---L 408

  Fly   256 AYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTS 320
            ..:.|..:|.      ...|..||.:.::.:|||||.:...:.:|.|:.:|:             
Human   409 KKFTPHHLVN------CDFPTNITCVVYSHDGTELLASYNDDDIYLFNSSHS------------- 454

  Fly   321 TLVHEEEPVKMPHRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATA 385
                                                                             
Human   455 ----------------------------------------------------------------- 454

  Fly   386 LMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCLQALIQRFPDFANNH 450
                                                                             
Human   455 ----------------------------------------------------------------- 454

  Fly   451 GVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTD 515
                                          ||                 ..|.:|:.||.|.|| 
Human   455 ------------------------------DG-----------------AQYSKRFKGHRNNTT- 471

  Fly   516 IKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHN 579
            :|..|:.|.:.||:.:|||.|:::.||..:.:|....:.. ...:||::|||.:.:||.||:||:
Human   472 VKGVNFYGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHD 536

  Fly   580 IKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELH 619
            :|||:|.|.:|.|    :..:.:.::.|  |...|...||
Human   537 VKIWTPTAKAATE----LTGLKKVIKKN--KWERDEDSLH 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
adpNP_001286563.1 WD40 54..>242 CDD:295369 63/191 (33%)
WD40 59..>242 CDD:225201 61/186 (33%)
WD40 repeat 72..108 CDD:293791 11/35 (31%)
WD40 repeat 114..154 CDD:293791 14/43 (33%)
WD40 repeat 158..203 CDD:293791 15/44 (34%)
WD40 repeat 214..268 CDD:293791 17/53 (32%)
TPR_11 341..410 CDD:290150 0/68 (0%)
TPR repeat 342..370 CDD:276809 0/27 (0%)
TPR repeat 375..408 CDD:276809 0/32 (0%)
TPR_11 378..444 CDD:290150 0/65 (0%)
TPR repeat 413..441 CDD:276809 0/27 (0%)
TPR_6 415..445 CDD:289917 0/29 (0%)
WD40 repeat 513..553 CDD:293791 14/39 (36%)
WD40 <524..>584 CDD:225201 22/60 (37%)
WD40 <526..584 CDD:295369 22/58 (38%)
DCAF8L2NP_001340377.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..163 0/1 (0%)
WD40 224..540 CDD:330360 111/524 (21%)
WD 1 226..265 16/38 (42%)
WD40 repeat 233..269 CDD:293791 11/35 (31%)
WD 2 269..310 16/42 (38%)
WD40 repeat 275..316 CDD:293791 14/42 (33%)
WD 3 316..356 15/42 (36%)
WD40 repeat 321..362 CDD:293791 15/47 (32%)
WD 4 364..404 13/39 (33%)
WD40 repeat 370..418 CDD:293791 16/50 (32%)
WD 5 420..459 13/228 (6%)
WD40 repeat 425..464 CDD:293791 14/228 (6%)
WD 6 467..507 15/40 (38%)
WD40 repeat 472..509 CDD:293791 12/36 (33%)
WD 7 511..550 18/42 (43%)
WD40 repeat 516..540 CDD:293791 12/23 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..631
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1334
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270484at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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