DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and iqw1

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_596313.1	Gene:	iqw1 / 2541121	PomBaseID:	SPBC609.03	Length:	809	Species:	Schizosaccharomyces pombe

Alignment Length:	775	Identity:	186/775 - (24%)
Similarity:	297/775 - (38%)	Gaps:	220/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LNASSLHWQRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSD 87
            ::..||..::..|.......:.|.:..:..::..::.:..|.||.||||.|:|:.||.:|.||||
pombe     1 MSGISLSLRQLDYRDWFQRKISRDIYGNSTWLTGIDLQKELTGHTGCVNTLDWSADGEFLLSGSD 65

  Fly    88 DYRVMIWDPFRK-KLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPN------ 145
            |.|:::||.|.: |..|:|.|.|:.|:||.||:|.:||..:.:.:.||.|.::|::...
pombe    66 DTRLIVWDVFNEYKPRHLISTGHVQNIFSAKFVPYSNNRQILSASGDKLIKLFDLDSSKEGGMDH 130

  Fly   146 --ETLFSC-ICHFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQ 207
              ||...| .|.....|.:... |:.|.|....|||...|.||||||.|..:......|:|.:..
pombe   131 GMETQTRCWSCALDSVKNIVPC-DNGHTFLVCSEDGTARQYDIREPHVCNQDLDCPSILVNYNPY 194

  Fly   208 LENTEAKCLAINPRRTEYLAVGTNDPFARVYDRRKLP---------STNGNGLSACVAYYAPGQI 263
            ..|...  :.::|....|.|:|...|:|.:||||.:.         :|:......||..::|...
pombe   195 RINLYT--ITMSPSNPYYFAIGGTHPYAFLYDRRMVKKSFRDDWTMNTSPEKDCRCVRKFSPDGS 257

  Fly   264 VKNISRNIVHEPRGITYLTFN-GNGTELLVNIGCEHVYRFDLNH--AEPPVFYDL------PAFT 319
            ..  |:.|:  .|.||...|: .|..||||:...::||.|.::.  :..|.|..:      |:..
pombe   258 CN--SQGIL--DRYITCCQFSAANPNELLVSWNSDYVYLFHVHEDKSYTPTFNKIEDSNKKPSKP 318

  Fly   320 STLVHEEEPVKMPHRS--------RSLP-----------------TEIEVYKKEGNDF-LENGKL 358
            |.|  :.:|:|..:.|        .|.|                 |..::|:.....| .|||.|
pombe   319 SLL--QTQPLKRKNYSPWYKNNFGASTPASRVSRNPYTAAQPRKHTFYQMYENIEKFFTTENGGL 381

  Fly   359 VDAI-----DAYSAALAKYPQGEVLYLN---------------RATAL----------------- 386
            .::|     ..:|.:: :|.:..:.:|.               |.:||
pombe   382 YESIVSGRLSHFSRSI-QYVKDAIYFLENYNYIPDSNGLNHSIRVSALRYWRACVSILALMDDTV 445

  Fly   387 -------MRRGWFGDIY----------AALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQ 434
                   ::.|| |.:|          ..:.| |.||::.|.     ..:||....|..|.:..:
pombe   446 SLEPNTIIQAGW-GWLYDFMNWVTRYLLGISD-HWALQMSPP-----TNVARQNFVLCDPDEPSR 503

  Fly   435 CL----QALIQRFPDFANN-----------HGV-----LMLNKDIKENRRQ---SKSPEAPELQP 476
            .|    ..:|:.|.....|           |.|     |:::.||...:.|   |.:.:....|.
pombe   504 VLFSNPSEMIRAFARIDTNDLSSVRRFFWIHKVLRGCLLLISSDIYWEQFQPWDSSTSDVTSSQR 568

  Fly   477 VEVDDGFRYLRLKNAEY--------------------DLRSTARDY------------------- 502
            ::.::||..|......|                    ||.....||
pombe   569 LDDENGFLTLLEPPVNYENEVESSSGENIVSMYTGHSDLNDDDDDYQDEESYSYASDDDDESDED 633

  Fly   503 ---------------------------MQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYI 540
                                       ::.|.|||||.: ||..|:.|...|::.:|||||..:|
pombe   634 SDEGPTLLSLRMKKRKAVEPNVPVNTHVKSYYGHCNVES-IKNVNFYGQNDEYVMSGSDDGRFFI 697

  Fly   541 WEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWS-----PCAASAEERPN 595
            |:.....|.|:...||..||.::.||....||.||||..:||::     |...|.....|
pombe   698 WDKLNASILAIIHGDSEAVNVIEGHPRCPTLAVSGIDSTVKIFNTENTPPSGCSRNHTSN 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	69/197 (35%)
		WD40	59..>242	CDD:225201	69/192 (36%)
		WD40 repeat	72..108	CDD:293791	17/36 (47%)
		WD40 repeat	114..154	CDD:293791	14/48 (29%)
		WD40 repeat	158..203	CDD:293791	16/44 (36%)
		WD40 repeat	214..268	CDD:293791	14/62 (23%)
		TPR_11	341..410	CDD:290150	21/123 (17%)
		TPR repeat	342..370	CDD:276809	8/33 (24%)
		TPR repeat	375..408	CDD:276809	12/81 (15%)
		TPR_11	378..444	CDD:290150	19/118 (16%)
		TPR repeat	413..441	CDD:276809	5/31 (16%)
		TPR_6	415..445	CDD:289917	7/33 (21%)
		WD40 repeat	513..553	CDD:293791	14/39 (36%)
		WD40	<524..>584	CDD:225201	24/59 (41%)
		WD40	<526..584	CDD:295369	24/57 (42%)
iqw1	NP_596313.1	WD40	32..>173	CDD:295369	51/141 (36%)
		WD40	<39..226	CDD:225201	68/189 (36%)
		WD40 repeat	49..87	CDD:293791	18/37 (49%)
		WD40 repeat	92..133	CDD:293791	11/40 (28%)
		WD40 repeat	139..183	CDD:293791	16/44 (36%)
		WD40 repeat	196..230	CDD:293791	11/35 (31%)
		WD40	<637..>761	CDD:225201	37/122 (30%)
		WD40	<659..741	CDD:295369	34/82 (41%)
		WD40 repeat	679..711	CDD:293791	11/31 (35%)
		WD40 repeat	716..742	CDD:293791	12/25 (48%)
		WD40 repeat	751..793	CDD:293791	2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I953
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005181
OrthoInspector	1	1.000	-	-		oto101198
orthoMCL	1	0.900	-	-		OOG6_104422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790