DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment adp and Dcaf8l

DIOPT Version :9

Sequence 1:	NP_001286563.1	Gene:	adp / 37073	FlyBaseID:	FBgn0000057	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_032847.2	Gene:	Dcaf8l / 18630	MGIID:	101758	Length:	747	Species:	Mus musculus

Alignment Length:	648	Identity:	137/648 - (21%)
Similarity:	220/648 - (33%)	Gaps:	251/648 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QRQHTPLNASSLHWQRQQYGHELDEM----------------------LRRRLLASPA------- 52
            |.:.:.::..:.....:||..|.|.:                      ||.|.|.|..
Mouse   270 QEESSEMHEETSEDSSEQYDIEDDSLIDEWIALETSPLPRPRWNVLSALRDRQLGSSGRFVYEAC 334

  Fly    53 ----YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRTKHLGNV 113
                :|.|...|.|..||.||||.:.:...|..|||||||.:|::||..:|:.|....:.|..|:
Mouse   335 GARLFVQRFSLEHVFEGHSGCVNTVHFNQHGTLLASGSDDLKVIVWDWLKKRSVLNFDSGHKNNI 399

  Fly   114 FSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFS--CICHFSRAKRLATAQDSPHVFWSAGE 176
            ...||||..|::|:|.|..|..:.|..::....|..:  .:.|...:.||....|||..|.::||
Mouse   400 LQAKFLPNCNDAILAMCGRDGQVRVAQLSAVAGTHMTKRLVKHGGASHRLGLEPDSPFRFLTSGE 464

  Fly   177 DGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTEYLAVGTNDPFARVYDRR 241
            |..:..:|:|:.|...       :||.:.|..:......:.:||......|||..|.|.|:||:|
Mouse   465 DAVVFNIDLRQAHPAS-------KLLVIKDGDKKVGLYTVFVNPANVYQFAVGGQDQFMRIYDQR 522

  Fly   242 KLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTELLVNIGCEHVYRFDLNH 306
            |:.....||:   :..:.|..::.:      ..|..||.|.::.:|||:|.:...|.:|.|:
Mouse   523 KIDENVNNGV---LKKFCPHHLLSS------DYPAHITSLMYSYDGTEILASYNDEDIYIFN--- 575

  Fly   307 AEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAK 371

Mouse   576 ----------------------------------------------------------------- 575

  Fly   372 YPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCL 436
                                                                     ..|:|
Mouse   576 ---------------------------------------------------------SSDSD--- 580

  Fly   437 QALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARD 501
                                                                          ...
Mouse   581 --------------------------------------------------------------GAQ 583

  Fly   502 YMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRAD-SAIVNCVQPH 565
            |.:||.||.|.:| :|...:.|.:.||:.:|||.|:::|||..:.:|.....|| ...:||:..|
Mouse   584 YAKRYKGHRNNST-VKGVYFYGPRSEFVMSGSDCGHIFIWEKSSCQIVQFLEADEGGTINCIDSH 647

  Fly   566 PSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELHTRNAYCFNN 628
            |.:.:||:||:||.:|||||.|..:::    :|.:...::.|  |::.|.|.|  |:...|||
Mouse   648 PYLPVLASSGLDHEVKIWSPIAEPSKK----LAGLKNVIKIN--KLKRDNFTL--RHTSLFNN 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_001286563.1	WD40	54..>242	CDD:295369	62/189 (33%)
		WD40	59..>242	CDD:225201	60/184 (33%)
		WD40 repeat	72..108	CDD:293791	13/35 (37%)
		WD40 repeat	114..154	CDD:293791	11/41 (27%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	15/53 (28%)
		TPR_11	341..410	CDD:290150	0/68 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR_11	378..444	CDD:290150	2/65 (3%)
		TPR repeat	413..441	CDD:276809	2/27 (7%)
		TPR_6	415..445	CDD:289917	2/29 (7%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<524..>584	CDD:225201	24/60 (40%)
		WD40	<526..584	CDD:295369	24/58 (41%)
Dcaf8l	NP_032847.2	WD40	345..666	CDD:392136	111/527 (21%)
		WD40 repeat	358..394	CDD:293791	13/35 (37%)
		WD40 repeat	400..441	CDD:293791	11/40 (28%)
		WD40 repeat	446..487	CDD:293791	14/47 (30%)
		WD40 repeat	495..543	CDD:293791	15/50 (30%)
		WD40 repeat	550..589	CDD:293791	14/228 (6%)
		WD40 repeat	597..634	CDD:293791	12/36 (33%)
		WD40 repeat	641..665	CDD:293791	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920