DRSC/TRiP Functional Genomics Resources

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Protein Alignment adp and DCAF8L1

DIOPT Version :9

Sequence 1:NP_001286563.1 Gene:adp / 37073 FlyBaseID:FBgn0000057 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_001017930.1 Gene:DCAF8L1 / 139425 HGNCID:31810 Length:600 Species:Homo sapiens


Alignment Length:582 Identity:127/582 - (21%)
Similarity:199/582 - (34%) Gaps:224/582 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 LRRRLLASPA-----------YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||:|.|.|.|           :|.|...:.:|..|.|.|:.:.:...|..|||..||.||::||.
Human   161 LRQRQLGSSARFVYEACGARTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDW 225

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPN--ETLFSCICHFSRAK 159
            .|:|.|....:.|..||...||.|...:|.:|.|..|..:.|.::.:.:  |.......|...|.
Human   226 VRQKPVLNFESGHDINVIQAKFFPNCGDSTLAMCGHDGQVRVAELINASYCENTKRVAKHRGPAH 290

  Fly   160 RLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTE 224
            .||...|||:.|.::|||..:..:|:|:.   ||...:.|    ..:..:......:::||....
Human   291 ELALEPDSPYKFLTSGEDAVVFTIDLRQD---RPASKVVV----TRENDKKVGLYTISMNPANIY 348

  Fly   225 YLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTE 289
            ..|||.:|.|.|:||:|::.....||:   :..:.|..:|      ....|..||.:.::.:|||
Human   349 QFAVGGHDQFVRIYDQRRIDKKENNGV---LKKFTPHHLV------YCDFPTNITCVVYSHDGTE 404

  Fly   290 LLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKEGNDFLE 354
            ||.:...|.:|.|                                               |..|.
Human   405 LLASYNDEDIYLF-----------------------------------------------NSSLS 422

  Fly   355 NGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRL 419
            :|                                                               
Human   423 DG--------------------------------------------------------------- 424

  Fly   420 ARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFR 484
                                                                             
Human   425 ----------------------------------------------------------------- 424

  Fly   485 YLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIR 549
                           ..|::||.||.|..| ||..|:.|.:.||:.:|||.|:::.||..:.:|.
Human   425 ---------------AQYVKRYKGHRNNDT-IKCVNFYGPRSEFVVSGSDCGHVFFWEKSSSQII 473

  Fly   550 AVYRADSA-IVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDNQEK 610
            .....|.. ||||::|||.:.:|||||:|.:::||:|.|.:|.|...| .||.:  ::.||:
Human   474 QFMEGDRGDIVNCLEPHPYLPVLATSGLDQHVRIWTPTAKTATELTGL-KDVIK--KNKQER 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
adpNP_001286563.1 WD40 54..>242 CDD:295369 57/189 (30%)
WD40 59..>242 CDD:225201 55/184 (30%)
WD40 repeat 72..108 CDD:293791 13/35 (37%)
WD40 repeat 114..154 CDD:293791 9/41 (22%)
WD40 repeat 158..203 CDD:293791 15/44 (34%)
WD40 repeat 214..268 CDD:293791 15/53 (28%)
TPR_11 341..410 CDD:290150 3/68 (4%)
TPR repeat 342..370 CDD:276809 3/27 (11%)
TPR repeat 375..408 CDD:276809 0/32 (0%)
TPR_11 378..444 CDD:290150 0/65 (0%)
TPR repeat 413..441 CDD:276809 0/27 (0%)
TPR_6 415..445 CDD:289917 0/29 (0%)
WD40 repeat 513..553 CDD:293791 14/39 (36%)
WD40 <524..>584 CDD:225201 24/60 (40%)
WD40 <526..584 CDD:295369 24/58 (41%)
DCAF8L1NP_001017930.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..122
WD40 189..>508 CDD:225201 108/525 (21%)
WD40 192..508 CDD:295369 108/522 (21%)
WD 1 194..233 16/38 (42%)
WD40 repeat 199..237 CDD:293791 14/37 (38%)
WD 2 237..278 11/40 (28%)
WD40 repeat 243..284 CDD:293791 9/40 (23%)
WD 3 284..324 15/42 (36%)
WD40 repeat 289..330 CDD:293791 15/47 (32%)
WD 4 332..372 11/39 (28%)
WD40 repeat 338..380 CDD:293791 13/44 (30%)
WD 5 388..427 14/228 (6%)
WD40 repeat 393..432 CDD:293791 15/228 (7%)
WD 6 435..475 15/40 (38%)
WD40 repeat 440..477 CDD:293791 13/36 (36%)
WD 7 479..518 19/38 (50%)
WD40 repeat 484..508 CDD:293791 12/23 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 562..600
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1334
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270484at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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