Protein Alignment CG5742 and ANKRD13B

DIOPT Version :10

• Sequence 1: NP_001261069.1
• Gene: CG5742 / 37072
• FlyBaseID: FBgn0034304
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_005257977.2
• Gene: ANKRD13B / 124930
• HGNCID: 26363
• Length: 779
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 175/606 - (28%)
• Similarity: 278/606 - (45%)
• Gaps: 145/606 - (23%)

  Fly    48 SPA---ERPPDKTSPTVAVAPTAKAASPLPTVKPA--------SEAL-------------DFPMH 88
            |||   .|||         ||..:|.:|.|::.|.        ..|:             .:|:|
Human   106 SPASRQRRPP---------APRPRAPAPAPSLLPGRAPRPRHEERAMIPANASARKGPEGKYPLH 161

  Fly    89 RSVFEDDIKSLQRRLLLSTAQDEVGRKDKHGNTPLHLAVMLGRKHAVRLLLAQNAPVKIKNNEGW 153
            ..|:.:..:.|::.  :...|.::.:.|..|.||||||..||.....|:|||..|.|..:|..||
Human   162 YLVWHNRHRELEKE--VRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGW 224

  Fly   154 SPLSEAISYGDRQTITQVLRMLKLQSREHMESRREKLVNALRQMQDFYMEFKWDFQSWLPLVSRI 218
            :.|.||:|..|.:.:..|||....|......:....|:..||:.||||:|.||:|.||:||||:|
Human   225 TVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKI 289

  Fly   219 LPSDICRLYKSGASIRLDTTLVDFNDMRWERGDISFLFRGEAPARESLVLLDNEQECFQRLRYEE 283
            .|||..:::|||.::|:||||:.|:.|.|:||:.||:|||:   ..|.|:::.:.:  :|:.|.|
Human   290 CPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQ---DTSAVVMEIDHD--RRVVYTE 349

  Fly   284 S----------------DMEDEVDVLMSTDILATQMSTKTIQFARAQRGWI-FRANRKELIGGQY 331
            :                ..|::|...::..::.||:.||.|.|.|.:.|.: :|:.:.|::.| |
Human   350 TLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNG-Y 413

  Fly   332 QCEIYTIQGLILKQRKRREHLSHEDLQKNRAIVETITKGASQQPDTRRSSLGSQHTATPPETNTP 396
            :.::|....:.|..|.|.||||.:...|        .||. :.|......:..||..  |:
Human   414 EAKVYGASNVELITRTRTEHLSEQHKGK--------VKGC-KTPLQSFLGIAEQHGG--PQ---- 463

  Fly   397 TAPNGISLPELPRRSSLQAPPPPTVTWRQYLDA--EVGKCPQLGRTPVHKQSNKT---------- 449
               ||..:.:     :|....|..:|..:|.:.  |:|. ..:|| |: :.:.||
Human   464 ---NGTLITQ-----TLSQANPTAITAEEYFNPNFELGN-RDMGR-PM-ELTTKTQNVPYPLGSG 517

  Fly   450 ---LRATVAMSKDFPLS----VDMLLDVLEVVAPLKHINKLREFVTLKLPTGFPVKIEIPVLHTV 507
               .:|.:.:.::.|||    |..::|::.|...|  ..|||:|:||:||.|||||||||:.|.:
Human   518 GGRFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNAL--FAKLRDFITLRLPPGFPVKIEIPIFHIL 580

  Fly   508 TAKVTFQKFEFRDN-IP----AKMFEVPSHYWEDVRRFQDLXPGDGEA----------------- 550
            .|::||......|. :|    :...|.||             ||...:
Human   581 NARITFGNLNGCDEPVPSVRGSPSSETPS-------------PGSDSSSVSSSSSTTSCRGCEIS 632

  Fly   551 -----APKAKAATGGPTGAAT 566
                 ||:..:..||...|||
Human   633 PALFEAPRGYSMMGGQREAAT 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5742	NP_001261069.1	ANKYR	<86..>175	CDD:440430	32/88 (36%)
		ANK repeat	86..116	CDD:293786	5/29 (17%)
		ANK repeat	118..149	CDD:293786	15/30 (50%)
		GPCR_chapero_1	234..534	CDD:463391	96/340 (28%)
ANKRD13B	XP_005257977.2	ANKYR	<146..>245	CDD:440430	31/100 (31%)
		ANK repeat	155..187	CDD:293786	5/33 (15%)
		ANK repeat	189..220	CDD:293786	15/30 (50%)
		GPCR_chapero_1	305..643	CDD:463391	100/384 (26%)