DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and Raver1

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_082187.1	Gene:	Raver1 / 71766	MGIID:	1919016	Length:	748	Species:	Mus musculus

Alignment Length:	595	Identity:	128/595 - (21%)
Similarity:	207/595 - (34%)	Gaps:	154/595 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ERALDTMNFDLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKV 121
            |:.|..::.:.:|.   |:..::|....||    .:.|:.|...:.|:.::|..|.: .:..|.|
Mouse    33 EQELPPLDPEEIRK---RLEHTERQFRNRR----KILIRGLPGDVTNQEVHDLLSDY-ELKYCFV 89

  Fly   122 ATDEKGNSKGYGFVHFETEEAANTSIDKVNGMLLNGK--KVYVGKFIPRKEREKELGEKAK-LFT 183
                 ...||..||                 .||||:  :..:..|...:.||:||..:.: ...
Mouse    90 -----DKYKGTAFV-----------------TLLNGEQAEAAINTFHQSRLRERELSVQLQPTDA 132

  Fly   184 NVYVKNFTEDFDDEKLKEFFEPYGKI-TSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKD 247
            .:.|.|........:.:|...|:|.: ..:.|.|:..|.|||:||..:...::|..|...|.||.
Mouse   133 LLCVANLPPSLTQAQFEELVRPFGSLERCFLVYSERTGHSKGYGFAEYMKKDSAARAKSDLLGKP 197

  Fly   248 MGEGKSLYVARAQKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDD-DRLRIAFSPYG 311
            :|. ::|||               .:.:..|.....:....|.|.:|.....| |.||.|.|...
Mouse   198 LGP-RTLYV---------------HWTDAGQLTPALLHSRCLCVDHLPPGFSDVDALRRALSVVY 246

  Fly   312 NITSAKVMTDEEGRSKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQY 376
            ..|..::...::|:.|||..:.:..|..|..|....:|:.:|...|.|:........::.||:..
Mouse   247 TPTFCQLACGQDGQLKGFAVLEYETAEMAEAAQERADGQALGDSHLRVSFCAPGPPGRSMLAALI 311

  Fly   377 MRHMTGMRMQQLGQIYQPNAASGFFVPTLPSNQRFFGSQVATQMRNTPRWVPQVRPPAAIQGVQA 441
            ....|.:...: |.:.:||...      |.:|   .|...:.|:...|          .:.|
Mouse   312 AAQATALNRGK-GLLPEPNLLQ------LLNN---LGPSASLQLLLNP----------LLHG--- 353

  Fly   442 GAAAAGGFQGTAGAVPTQFRSAAAGARGAQPQVQGTHAAAA---------AANNMRNTGARAITG 497
               .|.|.||..||.|            |.|.:.|...:.|         :.|..:......|.|
Mouse   354 ---GASGKQGLLGAPP------------AMPLLSGPALSTALLQLALQSQSQNQSQGQKKPGILG 403

  Fly   498 -------QQTAAPNMQIPGAQIAGGA------QQRTSNYKYTSNM------------RNPPVPQL 537
                   |..|.|:..:.|...|||.      .:|.........:            ..||..||
Mouse   404 DSPLGTLQAGAQPSNSLLGELSAGGGLAPELPPRRGKPQPLLPPLLGPSGGDREPMGLGPPATQL 468

  Fly   538 HQTQPIPQQLQGKNSEKLIASLLANAKPQEQ--------KQILGE-------RLYPMIEHMH--- 584
             ...|.|..|:|.|...|         |::.        ..:|||       .|.|.: ::|
Mouse   469 -TPPPAPVGLRGSNHRGL---------PKDSGPLPTPPGVSLLGEPPKDYRIPLNPYL-NLHSLL 522

  Fly   585 --ANLAGKIT 592
              :|||||.|
Mouse   523 PSSNLAGKET 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	128/595 (22%)
Raver1	NP_082187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		2/11 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	45..60		5/21 (24%)
		RRM1_RAVER1	59..129	CDD:241107	21/96 (22%)
		RRM_SF	133..209	CDD:302621	22/91 (24%)
		RRM3_RAVER1	219..306	CDD:241111	21/86 (24%)
		Interaction with PTBP1. /evidence=ECO:0000269\|PubMed:11724819	307..401		24/131 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..505		25/124 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..647		6/8 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..731
		Nuclear localization signal. /evidence=ECO:0000255	743..746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810