DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pAbp and Pabpc5

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001103836.1	Gene:	Pabpc5 / 688518	RGDID:	1587661	Length:	382	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	208/365 - (56%)
Similarity:	266/365 - (72%)	Gaps:	4/365 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNFD 66
            |:||||||..||.|..|:.||..|||:...|:|||.:||..|||.||||:.|||||.||:|||||
  Rat    18 AALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFD 82

  Fly    67 LVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSKG 131
            |:..||.|:||||.|..||:|||||:||||||::|||:|::..||||||||||||..|:.| |||
  Rat    83 LINGKPFRLMWSQPDDHLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNG-SKG 146

  Fly   132 YGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAK-LFTNVYVKNFTEDFD 195
            |.:|||::..|||.:|..:||:.||.::||||:|...:||..|:..:.: .||||:||||.:|.|
  Rat   147 YAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNFGDDID 211

  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQ 260
            |||||:.|..||...|.||:....|||||||||.:||.|||:.||..|:||.: :||.|.|.|||
  Rat   212 DEKLKKLFSEYGPTESVKVIRDATGKSKGFGFVRYETHEAAQKAVLELHGKSI-DGKVLCVGRAQ 275

  Fly   261 KKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGR 325
            ||.||..||:|:||.||.|......||.:|:||||:||:|::|:..||.:|:|:.||||. |.|:
  Rat   276 KKIERLAELRRRFERLKLKDKTRPPGVPIYIKNLDETINDEKLKEEFSLFGSISRAKVMM-EVGQ 339

  Fly   326 SKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRK 365
            .||||.|||::..||:.||.|:||||||||.|:|.|.|.:
  Rat   340 GKGFGVVCFSSFEEASKAVNEMNGRVVGSKTLHVTLGQAR 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	208/365 (57%)
Pabpc5	NP_001103836.1	RRM1_I_PABPs	22..98	CDD:240824	46/75 (61%)
		ELAV_HUD_SF	29..271	CDD:273741	139/243 (57%)
		RRM2_I_PABPs	104..179	CDD:240825	46/75 (61%)
		RRM3_I_PABPs	198..277	CDD:240826	47/79 (59%)
		RRM_SF	301..377	CDD:302621	44/76 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8281
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880