DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and pabpc1a

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001026846.1	Gene:	pabpc1a / 606498	ZFINID:	ZDB-GENE-030131-3238	Length:	634	Species:	Danio rerio

Alignment Length:	646	Identity:	379/646 - (58%)
Similarity:	462/646 - (71%)	Gaps:	46/646 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNF 65
            |||||||||..||.|:.|::|||.|||:||||||||::|||||||||||||||||||||||||||
Zfish    10 MASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMMTRRSLGYAYVNFQQPADAERALDTMNF 74

  Fly    66 DLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSK 130
            |:::.:|:||||||||||||:|||||:||||||::|||||:|||||||||||||||..||.| ||
Zfish    75 DVIKGRPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENG-SK 138

  Fly   131 GYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFD 195
            |||||||||.|||..:|:|:||||||.:||:||:|..|||||.|:|.:||.|||||:|||.||.|
Zfish   139 GYGFVHFETHEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAEMGARAKEFTNVYIKNFGEDMD 203

  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQ 260
            ||||||.|..||...|.:||:.:.|||||||||:||..|.|:.||..:|||:| .||.:||.|||
Zfish   204 DEKLKEIFCKYGPALSIRVMTDDSGKSKGFGFVSFERHEDAQRAVDEMNGKEM-NGKQVYVGRAQ 267

  Fly   261 KKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGR 325
            ||.|||.|||||||::||.|.....|||||||||||.:||:|||..|||:|.|||||||. |.||
Zfish   268 KKGERQTELKRKFEQMKQDRMTRYQGVNLYVKNLDDGLDDERLRKEFSPFGTITSAKVMM-EGGR 331

  Fly   326 SKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRM--QQL 388
            |||||||||::..|||.||||:|||:|.:||||||||||||||:|||.||||:.|..:|.  ..:
Zfish   332 SKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTSQYMQRMASVRAVPNPV 396

  Fly   389 GQIYQPNAASGFFVPTLPSNQR---FFGSQVATQMRNTPRWVPQVRPPAAIQGVQAGAAAAGGFQ 450
            ...|||...||:|:..:|..|.   ::.:....|:|.:|||        |.|||:
Zfish   397 LNPYQPAPPSGYFMAAIPQAQNRAAYYPTSQLAQLRPSPRW--------ATQGVR---------- 443

  Fly   451 GTAGAVPTQFRSAA-AGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQIAG 514
                  |..|::.. |..|.:.|:.|..:....|:...|...::.: |.|...|.....|| ..|
Zfish   444 ------PQHFQNMPNAAVRPSAPRPQTFNPVRPASQVPRMMTSQRM-GSQAMGPRPAAAGA-ATG 500

  Fly   515 GAQQR-TSNYKYTSNMRNPPVPQLHQTQP-IPQQ-----LQGKNSEKLIASLLANAKPQEQKQIL 572
            .||.| ...|||...:|||  .|...||| :|.|     :||:  |.|.||:||.|.||||||:|
Zfish   501 PAQVRGVPQYKYAPGVRNP--QQRMPTQPQVPMQQPAVHVQGQ--EPLTASMLAAAPPQEQKQML 561

  Fly   573 GERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTEPA 633
            ||||:|:|::||.:||||||||||||:|||||||:|..|:|::||:|||||||.|:..|.|
Zfish   562 GERLFPLIQNMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAA 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	373/635 (59%)
pabpc1a	NP_001026846.1	PABP-1234	11..614	CDD:130689	373/635 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5579
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I658
OMA	1	1.010	-	-		QHG53624
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	1	1.000	-	-		otm25179
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2216
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870