DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and raver1

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_021326440.1	Gene:	raver1 / 553693	ZFINID:	ZDB-GENE-050522-99	Length:	749	Species:	Danio rerio

Alignment Length:	749	Identity:	136/749 - (18%)
Similarity:	240/749 - (32%)	Gaps:	268/749 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YVNFQQPADAERALDTMNFDLVRNKPI-----------------------------RIMWSQRDP 82
            |.|:.|.|:    ::|..|:..:|...                             |:..::|:.
Zfish    28 YSNYDQTAE----IETWGFETAKNTEAEDECSPTGSDCPRRLDDELTALSPEEIASRLERTRREF 88

  Fly    83 SLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSKGYGFVHFETEEAANTSI 147
            ..||    .:.||||...|.|:.:::....: ::..|.|     ...||..||.....|.|..:|
Zfish    89 YNRR----KIIIKNLPADISNQEVHELLGNY-DLKYCFV-----DKYKGTAFVTLLNGEQAQFAI 143

  Fly   148 DKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFDDEKLKEFFEPYGKI-TS 211
            .:.:..:|..:::.|           :|.....|   :.:.|....|..::.:|...|:|.| ..
Zfish   144 KEFHQYVLRDREISV-----------QLQPTDAL---LCIANLPRAFTQQQFEELVRPFGNIERC 194

  Fly   212 YKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMG-------------------EGKSLYVA 257
            :.|.|...|.|||:|||.:...::|..|...|.||.:|                   ..:.|.|.
Zfish   195 FLVHSATTGHSKGYGFVEYMKKDSAARAKSELLGKQLGSRMLYVHWTEVGSLTFTMLHSRCLCVD 259

  Fly   258 RAQKKAERQQELK----------------------RKFEELKQKRHESVFGVNLYVKNLD-DTID 299
            |..:.....|:|:                      |:|..|:....|....|.   :..| ..:.
Zfish   260 RLPQHILTAQDLRNVLTDTHAPVFCQLAQGQDCSFRRFAVLEFSTPEMAEDVQ---RQTDARALG 321

  Fly   300 DDRLRIAF----SPYGNITSAKVMTDEEGRSKGFGFVCFNAASEATCAVTELNG----------- 349
            |..:|::|    .|..::.:|.:.......::|.|.:   ....|...:|.||.
Zfish   322 DSHIRVSFCAPGPPGRSMLAALIAAQTMALNRGKGLL---PEPNAMQILTGLNNPATLKMLMASL 383

  Fly   350 ------RVVGSKP-------------LYVALAQRKEERKAHLAS----QYMRH------------ 379
                  .::|:.|             |...|.|.:.:::|.|.:    .::.|
Zfish   384 NPAHKQGLLGAAPAVPLLANPALSAALMQMLLQNQVQQQALLGNPLLWAHILHNKEYSLLPCAGL 448

  Fly   380 -----MTGMRMQQ----LGQIYQPNAASGFFVPTL------------PSNQRFFGSQVATQMRNT 423
                 :..:.:||    ||::.|     |...|.|            ||..|..|.:..|..  |
Zfish   449 LSDNPLAALPLQQGINMLGEMPQ-----GALAPALGLQNESLGPIKQPSLSRPLGRESETPA--T 506

  Fly   424 PRWVPQVRPPAAIQGVQ----AGAAAAGGF------------------QGTAGAVPTQFRSAAAG 466
            |...|....| .:||:.    :|...|.|.                  |....:.|:.|.|::|.
Zfish   507 PIGFPPASSP-VLQGMNMPLLSGILGADGLTLPGVSILGEPPKDVGVSQNPFLSSPSIFPSSSAS 570

  Fly   467 ARGAQPQVQGTHAAAAAANNMR-NTGARA-----------------------ITGQQTAAPNMQI 507
            .| |.|..:.|  ...:.:|:| |.|..:                       :..||....|..:
Zfish   571 TR-AHPYRKRT--PLGSMSNLRTNHGIHSNYNLRFQESCTPEFSLHQDPLSHLYEQQEVLENAAL 632

  Fly   508 PG-----AQIAG----------------------GAQQRTSNYKYTSNMRNPPV--PQLHQTQP- 542
            ||     ::.||                      ||.....:.:....:..|||  |.|....|
Zfish   633 PGYGLQNSRHAGFSDAGSLFSYPPSPPQSSYFSFGAHSNIPSTQLNKAVGMPPVTHPSLFSAAPG 697

  Fly   543 --IPQQLQGKNSEKLIASLLANAKPQEQKQILGE 574
              :...:.|:  ::|.:.|:.:.:|..:...:|:
Zfish   698 AGMKTPIGGQ--KRLFSRLIPSPEPSPEGGYVGQ 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	136/749 (18%)
raver1	XP_021326440.1	RRM1_RAVER1	92..162	CDD:241107	19/90 (21%)
		RRM2_RAVER1	166..242	CDD:241109	22/78 (28%)
		RRM_SF	252..343	CDD:327398	15/93 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810