DRSC/TRiP Functional Genomics Resources

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Protein Alignment pAbp and NCL

DIOPT Version :9

Sequence 1:NP_476667.1 Gene:pAbp / 37070 FlyBaseID:FBgn0265297 Length:634 Species:Drosophila melanogaster
Sequence 2:NP_005372.2 Gene:NCL / 4691 HGNCID:7667 Length:710 Species:Homo sapiens


Alignment Length:373 Identity:96/373 - (25%)
Similarity:177/373 - (47%) Gaps:61/373 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SLYVGDLPQDVNES------GLFDKFSSAG-PVLSIRVCRDVITRRSLGYAYVNFQQPADAERAL 60
            :|:||:|  :.|:|      |:.|.|:... .|:.:|:   .:||:   :.||:|:...|.|:||
Human   308 NLFVGNL--NFNKSAPELKTGISDVFAKNDLAVVDVRI---GMTRK---FGYVDFESAEDLEKAL 364

  Fly    61 DTMNFDLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDE 125
            :.....:..|: |::...:...|.:......:..|||...:....:.:.|.....|.    ...:
Human   365 ELTGLKVFGNE-IKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIR----LVSK 424

  Fly   126 KGNSKGYGFVHFETEEAANTSIDKVNGMLLNGKKV---YVGKFIPRKEREKELGEKAKLFT---- 183
            .|.|||..::.|:||..|..:.::..|..::|:.:   |.|:   :.:.:...|.|...::    
Human   425 DGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGE---KGQNQDYRGGKNSTWSGESK 486

  Fly   184 NVYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDM 248
            .:.:.|.:....:|.|:|.||   |.|..||...::|||||:.|:.|.:.|.|:.|:.:.|.:::
Human   487 TLVLSNLSYSATEETLQEVFE---KATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREI 548

  Fly   249 GEGKSLYV----ARAQKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSP 309
             ||:::.:    .|....| |.|..|                 .|:||.|.:...::.|:.:|. 
Human   549 -EGRAIRLELQGPRGSPNA-RSQPSK-----------------TLFVKGLSEDTTEETLKESFD- 593

  Fly   310 YGNITSAKVMTDEE-GRSKGFGFVCFNAASEATCAVTEL-NGRVVGSK 355
             |:: .|:::||.| |.|||||||.||:..:|..|...: :|.:.|:|
Human   594 -GSV-RARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNK 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pAbpNP_476667.1 PABP-1234 2..625 CDD:130689 96/373 (26%)
NCLNP_005372.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..303
8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X 58..135
RRM1_NCL 307..381 CDD:240849 22/81 (27%)
RRM 379..628 CDD:223796 71/280 (25%)
RRM2_NCL 390..465 CDD:240850 16/78 (21%)
RRM3_NCL 485..557 CDD:240851 23/75 (31%)
RRM4_NCL 572..649 CDD:240852 27/88 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..710 96/373 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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