DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and Ncl

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_036881.2	Gene:	Ncl / 25135	RGDID:	3153	Length:	714	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	99/373 - (26%)
Similarity:	172/373 - (46%)	Gaps:	62/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLYVGDLPQD-------VNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERAL 60
            :|::|:|..:       |..|.||.|...|..        ||.|..:..:.||:|:...|.|:||
  Rat   313 NLFIGNLNPNKSVAELKVAISELFAKNDLAAV--------DVRTGTNRKFGYVDFESAEDLEKAL 369

  Fly    61 DTMNFDLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDE 125
            :.....:..|: |::...:...|.:......:..|||...|....:.:.|.   :.:..::.:.:
  Rat   370 ELTGLKVFGNE-IKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFE---DAVEIRLVSQD 430

  Fly   126 KGNSKGYGFVHFETEEAANTSIDKVNGMLLNGKKV---YVGKFIPRKEREKE----LGEKAKLFT 183
             |.|||..::.|::|..|..::::..|..::|:.|   |.|:...|:||..:    .||...|
  Rat   431 -GRSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTL-- 492

  Fly   184 NVYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDM 248
              .:.|.:....:|.|:|.||   |.|..||.....|||||:.|:.|.:.|.|:.|:.:.|..::
  Rat   493 --VLSNLSYSATEETLQEVFE---KATFIKVPQNPHGKSKGYAFIEFASFEDAKEALNSCNKMEI 552

  Fly   249 GEGKSLYV----ARAQKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSP 309
             ||:::.:    .|....| |.|..|                 .|:||.|.:...::.|:.:|.
  Rat   553 -EGRTIRLELQGPRGSPNA-RSQPSK-----------------TLFVKGLSEDTTEETLKESFE- 597

  Fly   310 YGNITSAKVMTDEE-GRSKGFGFVCFNAASEATCAVTEL-NGRVVGSK 355
             |:: .|:::||.| |.|||||||.||:..:|..|...: :|.:.|:|
  Rat   598 -GSV-RARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNK 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	99/373 (27%)
Ncl	NP_036881.2	8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	312..386	CDD:240849	21/81 (26%)
		RRM2_NCL	395..470	CDD:240850	16/78 (21%)
		RRM3_NCL	489..561	CDD:240851	24/79 (30%)
		RRM4_NCL	576..653	CDD:240852	27/88 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810