DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and Pabpc2

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_035163.1	Gene:	Pabpc2 / 18459	MGIID:	1349723	Length:	628	Species:	Mus musculus

Alignment Length:	652	Identity:	361/652 - (55%)
Similarity:	443/652 - (67%)	Gaps:	65/652 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNF 65
            |||||||||..||.|:.|::|||||||:|||||.||||||||||||.|||:||||||||||||||
Mouse    10 MASLYVGDLHPDVTEAMLYEKFSSAGPILSIRVYRDVITRRSLGYASVNFEQPADAERALDTMNF 74

  Fly    66 DLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSK 130
            |:::.||:||||||||||||||||||||||||::.|||||:|||||||||||||||.:||.| ||
Mouse    75 DVIKGKPVRIMWSQRDPSLRRSGVGNVFIKNLNKTIDNKALYDTFSAFGNILSCKVVSDENG-SK 138

  Fly   131 GYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFD 195
            |:|||||||||||..:|:|:||||||.:||:||:|..:||||.|||...|.|||||:|||.:..|
Mouse   139 GHGFVHFETEEAAERAIEKMNGMLLNDRKVFVGRFKSQKEREAELGTGTKEFTNVYIKNFGDRMD 203

  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQ 260
            ||.|...|..:|:|.|.|||:.|.|||||||||:||..|.|:.||..:|||:: .||.:||.|||
Mouse   204 DETLNGLFGRFGQILSVKVMTDEGGKSKGFGFVSFERHEDAQKAVDEMNGKEL-NGKHIYVGRAQ 267

  Fly   261 KKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGR 325
            ||.:|..|||.|||::.|.:.....|:|||||||||.|||:||:..|||:|.|||.|||| |.||
Mouse   268 KKDDRHTELKHKFEQVTQDKSIRYQGINLYVKNLDDGIDDERLQKEFSPFGTITSTKVMT-EGGR 331

  Fly   326 SKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLG- 389
            |||||||||::..|||.||:|:|||:|.:||||||||||||||:|||.:||::.|..:|.   |
Mouse   332 SKGFGFVCFSSPEEATKAVSEMNGRIVATKPLYVALAQRKEERQAHLTNQYIQRMASVRS---GP 393

  Fly   390 ---QIYQPNAASGFFVPTLPSNQRFF---GSQVATQMRNTPRWVPQVRPPAAIQGVQAGAAAAGG 448
               ..||| |:|.:.|..:|..|...   .||:| |.|.:.||:.|...|..
Mouse   394 NPVNPYQP-ASSSYSVAAVPQTQNCVPCCPSQIA-QPRPSARWIAQGSRPHP------------- 443

  Fly   449 FQGTAGAV-PTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQ-------TAAPNM 505
            |....||: |...||:....|.:...||.|     .|:.:.||.|: ||||:       ||.|..
Mouse   444 FPNVPGAIHPAAPRSSLTTVRPSSSHVQVT-----TAHRITNTSAQ-ITGQRPAPASSATATPVH 502

  Fly   506 QIPGAQIAGGAQQRTSNYKYTSNMRNPPVPQLHQTQPIPQQ----LQGKNSEKLIASLLANAKPQ 566
            .||             .|||.:.::|   .|.|....:.||    :||:  |...||:|..| ||
Mouse   503 SIP-------------QYKYAAGVQN---SQQHLNAQLAQQPAVCIQGQ--EPWTASMLVTA-PQ 548

  Fly   567 EQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTE 631
            |.||:|||||:|:|:.||..||||||||||:|:|||.|.|:|...:..::.|||||.||.|:|.|
Mouse   549 EPKQMLGERLFPLIQAMHPTLAGKITGMLLDIDNSEPLRMLESPVSRCSRAEEAVATLQAHQVKE 613

  Fly   632 PA 633
            .|
Mouse   614 AA 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	354/641 (55%)
Pabpc2	NP_035163.1	PABP-1234	11..607	CDD:130689	354/641 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5666
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I653
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53624
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	1	1.000	-	-		otm44188
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840