DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pAbp and Pabpc1

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_032800.2	Gene:	Pabpc1 / 18458	MGIID:	1349722	Length:	636	Species:	Mus musculus

Alignment Length:	648	Identity:	385/648 - (59%)
Similarity:	460/648 - (70%)	Gaps:	49/648 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNF 65
            |||||||||..||.|:.|::|||.|||:||||||||:||||||||||||||||||||||||||||
Mouse    10 MASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNF 74

  Fly    66 DLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSK 130
            |:::.||:||||||||||||:|||||:||||||::|||||:|||||||||||||||..||.| ||
Mouse    75 DVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENG-SK 138

  Fly   131 GYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFD 195
            |||||||||:|||..:|:|:||||||.:||:||:|..|||||.|||.:||.|||||:|||.||.|
Mouse   139 GYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMD 203

  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQ 260
            ||:|||.|..:|...|.|||:.|.|||||||||:||..|.|:.||..:|||:: .||.:||.|||
Mouse   204 DERLKELFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKEL-NGKQIYVGRAQ 267

  Fly   261 KKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGR 325
            ||.|||.|||||||::||.|.....|||||||||||.|||:|||..|||:|.|||||||. |.||
Mouse   268 KKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMM-EGGR 331

  Fly   326 SKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLGQ 390
            |||||||||::..|||.||||:|||:|.:||||||||||||||:|||.:|||:.|..:|......
Mouse   332 SKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPV 396

  Fly   391 I--YQPNAASGFFVPTLPSNQR----FFGSQVATQMRNTPRWVPQ-VRPPAAIQGVQAGAAAAGG 448
            |  |||...||:|:..:|..|.    :..||:| |:|.:|||..| .||..
Mouse   397 INPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIA-QLRPSPRWTAQGARPHP-------------- 446

  Fly   449 FQGTAGAV-PTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQI 512
            ||...||: |...|...:..|.|..||....:....||          |..||..|.   |.|..
Mouse   447 FQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVAN----------TSTQTMGPR---PAAAA 498

  Fly   513 AGG--AQQRTSNYKYTSNMRNP-----PVPQLHQTQPIPQQLQGKNSEKLIASLLANAKPQEQKQ 570
            |..  |.:....|||.:.:|||     ..||:...|| ...:||:  |.|.||:||:|.||||||
Mouse   499 AAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQP-AVHVQGQ--EPLTASMLASAPPQEQKQ 560

  Fly   571 ILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTEPA 633
            :|||||:|:|:.||.:||||||||||||:|||||||:|..|:|::||:|||||||.|:..|.|
Mouse   561 MLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAA 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	379/637 (59%)
Pabpc1	NP_032800.2	PABP-1234	11..615	CDD:130689	379/637 (59%)
Pabpc1	NP_032800.2	CSDE1-binding. /evidence=ECO:0000250	166..289		78/123 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5666
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I653
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53624
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	1	1.000	-	-		otm44188
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2216
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870