DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pAbp and pab-1

DIOPT Version :9

Sequence 1:	NP_476667.1	Gene:	pAbp / 37070	FlyBaseID:	FBgn0265297	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001369814.1	Gene:	pab-1 / 172920	WormBaseID:	WBGene00003902	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	638	Identity:	352/638 - (55%)
Similarity:	426/638 - (66%)	Gaps:	42/638 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNF 65
            |||||||||..|||||.||:|||:||||||||||||..||.||||||||||||||||||:|||||
Worm    31 MASLYVGDLHPDVNESILFEKFSAAGPVLSIRVCRDNATRLSLGYAYVNFQQPADAERAMDTMNF 95

  Fly    66 DLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSK 130
            :.:..||:|||||||||::||||.||:||||||:.||||:||||||.||||||||||.||.|.||
Worm    96 EALHGKPMRIMWSQRDPAMRRSGAGNIFIKNLDKVIDNKSIYDTFSLFGNILSCKVAIDEDGFSK 160

  Fly   131 GYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFD 195
            |||||||||||||..:|.|||||||.||||:||||.||.:|.:||||.||.|||||||||.:.::
Worm   161 GYGFVHFETEEAAQNAIQKVNGMLLAGKKVFVGKFQPRAQRNRELGETAKQFTNVYVKNFGDHYN 225

  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDM-GEGKSLYVARA 259
            .|.|::.|..:|.|||.:||:.| |||||||||||...|.||.|||||:...: |....|:|.||
Worm   226 KETLEKLFAKFGNITSCEVMTVE-GKSKGFGFVAFANPEEAETAVQALHDSTIEGTDLKLHVCRA 289

  Fly   260 QKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEG 324
            |||:||..|||:|.|:.|.:|.:...||||||||||:|:|||.|:..|..|||||||||||||.|
Worm   290 QKKSERHAELKKKHEQHKAERMQKYQGVNLYVKNLDETVDDDGLKKQFESYGNITSAKVMTDENG 354

  Fly   325 RSKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLG 389
            ||||||||||....|||.||||:|.::|.|||||||:|||||:|:|.||||||:.:..|||.  |
Worm   355 RSKGFGFVCFEKPEEATSAVTEMNSKMVCSKPLYVAIAQRKEDRRAQLASQYMQRLASMRMH--G 417

  Fly   390 QI-----YQP-NAASGFFVPTLPSNQR-FFGSQVATQMRNTPRWVPQVRPPAAIQGVQAGAAAAG 447
            .:     |.| ....|::|......|| |.|.|  ..:|...||..|.:.|  :|.....|...|
Worm   418 NVPGAAMYNPTQPGPGYYVANPMQQQRNFAGGQ--QMVRPGGRWGMQNQYP--VQNQYMMAQGPG 478

  Fly   448 GFQGTAGAVPTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQ- 511
            .:|...|....|    ..|.||...|.          |.:...|.|     ....|..|.||.|
Worm   479 VYQNRMGRPQNQ----QGGPRGPPQQY----------NQVAQGGVR-----MQGPPRTQNPGVQQ 524

  Fly   512 --IAGGAQQRTSNYKYTSNMRNPPVP-QLHQTQPIPQQLQGKNSEKLIASLLANAKPQEQKQILG 573
              :....||:.......:..:.||.| |.:|.:  ||.:.....|.|.:::||.|.||||||:||
Worm   525 QNVPRPPQQQQQQRPAPTGPKAPPQPYQAYQQR--PQGIVIGGQEPLTSAMLAAAAPQEQKQLLG 587

  Fly   574 ERLYPMIEHMHANL--AGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVL 624
            ||:|.:||.::...  |||||||:|||:||||:.|::|.|..::||:||.:||
Worm   588 ERIYALIEKLYPGHKDAGKITGMMLEIDNSELIMMLQDSELFRSKVDEAASVL 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	351/637 (55%)
pab-1	NP_001369814.1	PABP-1234	32..640	CDD:130689	349/635 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I3840
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	609	1.000	Inparanoid score	I497
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53624
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	1	1.000	-	-		otm14629
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2216
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010