DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and phf19

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	XP_031746404.1	Gene:	phf19 / 779900	XenbaseID:	XB-GENE-920076	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	185/718 - (25%)
Similarity:	280/718 - (38%)	Gaps:	206/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 VTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGG 411
            |:.|..:.|..:..||.:|||.|  :..:....|:.|:|.|:.|.....::.        ||..|
Frog    37 VSQAEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLFKDIQH--------AGVPG 93

  Fly   412 ASTTESTNTSPSGPMCVAC--KRSDIEDVVEICERCGRGYHRGCTVEIVTGSG------IWSCKR 468
            ..           |.|..|  |.|...:.:.||.:||.|||:.|.:.:| .||      .|.|:|
Frog    94 EQ-----------PKCNVCTGKSSLPLNEILICGKCGLGYHQKCHIPVV-DSGENGPLEPWFCRR 146

  Fly   469 CAKPMKMQQ-------PVSHKITKPAGICRQLPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHN 526
            |...:.:::       |::..:   ..:...|.|...:|.||..||.|::|.|||||.||::...
Frog   147 CIFVLAVRKGGALKKGPIAKAL---QAVKMYLTYSPTELDWDSPHRTNQQQCYCYCGGPGEWYLK 208

  Fly   527 MLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKH 591
            |:||.:||.|||..|||...:.::.||.|:.|.|:|||.|.||::|:.:.|||::|:|||||...
Frog   209 MIQCYRCRQWFHEACMQCLNEPMMFGDRFYAFLCSVCNQGSEFLKRLPLRWVDIVHLALYNLGVL 273

  Fly   592 QHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMER---LKQTLKDYSDRFVCGREFKRAP 653
            ..:||.. ..:|..|:.:....|.:.:...||.|    ||   |...|..|..||:||:|.||..
Frog   274 SKKKYFD-FEEILTFVNDNWDHLQLGKIAATLVE----ERAHHLLDALNSYKSRFLCGKEIKRKK 333

  Fly   654 AFYALRHSGPPH-----IPKVFLEPHEELSDELLEK-RFKLMLMPEEPDEGANELPKRVPKDVYE 712
            ..:.||...||.     :|:..:...|..|.:|.:| |.|.        ...|.||       :|
Frog   334 CIFRLRIRVPPSPPGKLLPEKAVGTAESRSADLKKKGRSKY--------SHKNSLP-------HE 383

  Fly   713 FNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPL 777
            ........:...:.:..::..|..:...:|...:.|     ...:.|...::         |..|
Frog   384 CQRQRQQGIRRKQSKFLLEDAIPSSDFTSAWSTNHH-----LASIFDFTLDE---------IQSL 434

  Fly   778 LDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFLGRNNPFLMATPK 842
            ..|:|.:...:              ||.|::.:|:| |::|..|
Frog   435 KSASSGQNFTS--------------DLDSNDAASTS-GSASTSL--------------------- 463

  Fly   843 KASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRR---RT 904
                                         |.|....|.:.||:.::|..|   :.|.:||   ||
Frog   464 -----------------------------SCESRGNVGSRKRKFASKKYT---SFEAKRRAVDRT 496

  Fly   905 RRL----TTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRN 965
            .||    |.|.|.:.               |.|.|.                           .:
Frog   497 GRLNGCATEAAEYVG---------------ASDYQD---------------------------HS 519

  Fly   966 STSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWG 1030
            ..|.|..|.|.|..     |:..||.|:..|||.| .|:..||.:.:.|:|....|:|||||||.
Frog   520 IESRTFDSLSENDT-----SLSHLKSSITSYFGAA-GRMACGEKYQVLARRVTLEGKVQYLVEWE 578

  Fly  1031 GDT 1033
            |.|
Frog   579 GTT 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	13/50 (26%)
		PHD_SF	426..469	CDD:304600	17/50 (34%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	25/50 (50%)
		Mtf2_C	985..1032	CDD:290768	21/46 (46%)
phf19	XP_031746404.1	Tudor_PHF19	38..94	CDD:410522	15/63 (24%)
		PHD1_PHF19	97..149	CDD:277054	19/52 (37%)
		PHD2_PHF19	196..247	CDD:277056	25/50 (50%)
		Mtf2_C	534..581	CDD:404871	22/47 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12524
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12628
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100