DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pcl and Phf19

DIOPT Version :10

Sequence 1:NP_476672.1 Gene:Pcl / 37069 FlyBaseID:FBgn0003044 Length:1043 Species:Drosophila melanogaster
Sequence 2:NP_082992.1 Gene:Phf19 / 74016 MGIID:1921266 Length:578 Species:Mus musculus


Alignment Length:782 Identity:188/782 - (24%)
Similarity:284/782 - (36%) Gaps:234/782 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 QTPPTTPEAMSSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPAPPVA 343
            :|....|..:.:.|.:||:.         .|::..|.:||.:.:                     
Mouse     2 ETQALEPGTLEAFGATSPNK---------GGLSKTKKNFKDLMS--------------------- 36

  Fly   344 APSPAVTYALQEDVFIKC--NDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSS 404
                    .:.|..|:.|  .||.:|||.|  :.......|:.|:|.|:.|.....::.      
Mouse    37 --------KVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQH------ 87

  Fly   405 ITAGGGGASTTESTNTSPSGPMCVAC--KRSDIEDVVEICERCGRGYHRGCTVEIVTGSG----- 462
              ||..|..           |.|..|  |.|...:.:.||.:||.|||:.|.:.|...:.     
Mouse    88 --AGVPGEE-----------PKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLT 139

  Fly   463 IWSCKRCAKPMKMQQPVSHK---ITKPAGICRQ-LPYHADKLSWDEKHRVNEEQIYCYCGKPGKF 523
            .|.|:||...:.:::..:.|   |.|.....:. |.|..::|.||..||.|::|.|||||.||::
Mouse   140 HWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEW 204

  Fly   524 DHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNL 588
            ...||||.:||.|||..|.|...:.::.||.|::|.|:|||.|.|::.|:.:.|||::|:|||||
Mouse   205 YLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNL 269

  Fly   589 RKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMER---LKQTLKDYSDRFVCGREFK 650
            .....::|.. ..:|..|:   .|...:.:..: |..|.:.||   |...|..|..||:||:|.|
Mouse   270 GVQSKKRYFD-FEEILAFV---NHHWELLQLGK-LTSTPMTERGPHLLNALNSYKSRFLCGKEIK 329

  Fly   651 RAPAFYALRHSGPPH-----IPKVFLEPHEELSDELLEKRFKLM--LMPEEPDEGANELPKRVPK 708
            :....:.||...||.     :|...|.|.::.:.|||.|:.|..  |:|:||.:....:.:|...
Mouse   330 KKKCIFRLRIRVPPAPPGKLLPDRALMPSDKGTSELLRKKGKSKPGLLPQEPQQQKRRVYRRKRS 394

  Fly   709 DVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAP 773
            ..            ..||.||....      .:|...|.|                         
Mouse   395 KF------------LLEDAIPSSDF------TSAWSTDHH------------------------- 416

  Fly   774 IPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFLGRNNPFLM 838
                             |:..:       |.:.||..|...|:|               ...|..
Mouse   417 -----------------LASIF-------DFTLDEIQSLKSGSS---------------GQTFFS 442

  Fly   839 ATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRRR 903
            ......:...|.|..|.:               |.:....|.:.||:|:||         |.|  
Mouse   443 DVDSTDAASTSGSASTSL---------------SYDSRWTVGSRKRKLTAK---------VHR-- 481

  Fly   904 TRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQS--PSQSRRNS 966
                                    |:.||.       ......||.......:.:  |.|.....
Mouse   482 ------------------------PLRAKQ-------RAAELEGRCASDSNAEGAVGPEQPDEGI 515

  Fly   967 TSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGG 1031
            .|.|..|     |.....|:..||.|:..|||.| .|:..||.:.:.|:|....|:||||:||.|
Mouse   516 DSHTLES-----ISGDDSSLSHLKSSITNYFGAA-GRLACGEKYRVLARRVTPEGKVQYLLEWEG 574

  Fly  1032 DT 1033
            .|
Mouse   575 TT 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PclNP_476672.1 PRK12323 <13..107 CDD:481241
Tudor_dPCL-like 350..401 CDD:410523 14/54 (26%)
PHD_SF 426..469 CDD:473978 15/49 (31%)
PHD2_MTF2_PHF19_like 514..565 CDD:276978 25/50 (50%)
Mtf2_C 985..1033 CDD:464077 21/47 (45%)
Phf19NP_082992.1 Tudor_PHF19 37..93 CDD:410522 16/63 (25%)
Histone H3K36me3 binding. /evidence=ECO:0000250 72..78 3/5 (60%)
PHD_SF 96..148 CDD:473978 17/51 (33%)
PHD2_PHF19 195..246 CDD:277056 25/50 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..390 12/41 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..528 9/53 (17%)
Interaction with SUZ12. /evidence=ECO:0000250|UniProtKB:Q5T6S3 529..578 22/49 (45%)
Mtf2_C 529..576 CDD:464077 21/47 (45%)
Important for PRC2 dimer stability. /evidence=ECO:0000250|UniProtKB:Q5T6S3 529..542 5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

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