DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcl and phf19

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	XP_005166909.1	Gene:	phf19 / 560078	ZFINID:	ZDB-GENE-081105-128	Length:	563	Species:	Danio rerio

Alignment Length:	715	Identity:	176/715 - (24%)
Similarity:	267/715 - (37%)	Gaps:	235/715 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 FIKC--NDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTEST 418
            ::.|  :||.:|||.|  :..:.....:.|:|.|:.|.....::.        ||..|..
Zfish    43 YVLCCWSDGLYYLGKIQRVSTSKQSCFVSFEDNSKFWVLWKDIQH--------AGIPGEE----- 94

  Fly   419 NTSPSGPMCVACKRSDIE--DVVEICERCGRGYHRGC---TVEIVTGSGIWSCKRCAKPMKMQQP 478
                  |.|..|....::  :.:.||.:||.|:|:.|   |||.......|.|:||...:.:::.
Zfish    95 ------PKCSVCSDMSLDPGNEILICGKCGVGFHQLCHLPTVESSADPSPWFCRRCIFALAVRKG 153

  Fly   479 VSHK---ITKPAGICRQ-LPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHT 539
            .:.|   :.|.....:| |.|:.::|.||..||.|.:|.|||||.||::...||||.:|..|||.
Zfish   154 GALKKGQLAKDLQAMKQVLTYNPEELEWDSLHRTNHQQCYCYCGGPGQWYLKMLQCFRCEQWFHE 218

  Fly   540 QCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHL----- 599
            .|.|..:..::.||.|::|.|.|||.|:|:::|:.:.||||:|:|||||.....:||..|
Zfish   219 ACTQCLQDSMMFGDRFYLFICAVCNKGVEYIKRLALRWVDVVHLALYNLGVQSKKKYFELEEIVA 283

  Fly   600 -LNDIWPFILEQRHQLPICEKWRTLPETALMER---LKQTLKDYSDRFVCGREFKRAPAFYALRH 660
             :|:.|     .|.|:      ..|..|.|.||   :...|.:|..:|:||:|.|:....:.||.
Zfish   284 FINNNW-----DRFQM------GKLSNTPLPERGQLILDALNNYKSKFLCGKEIKKRKCIFRLRT 337

  Fly   661 SGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFNTDEDDPVETSE 725
            ..||:.|.                                   |..|
Zfish   338 RVPPNPPS-----------------------------------KLYP------------------ 349

  Fly   726 DEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKA-F 789
                     |||:|..|.:..|.         |...:::.||            |...||::| :
Zfish   350 ---------EKAQKSDAHRGRKK---------AVSRSSNSDP------------AEKRRKKRAKW 384

  Fly   790 RLSKRYDN-------SRNH-----CDLSSDE----NSSSSRGTSSLDLIIPPPVNFLGRNNPFLM 838
            .|.....|       |.||     .|.:.||    .|:||..|.|||           :::....
Zfish   385 LLEDAIPNNDLTSSWSTNHHMANIFDFTLDELQSLKSTSSGQTFSLD-----------QDSTDAA 438

  Fly   839 ATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRRR 903
            :|...|:...|......||                       :.||:|...:..:
Zfish   439 STSGSATTSVSYDFRKNVG-----------------------SRKRKLPTSNYNL---------- 470

  Fly   904 TRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRNSTS 968
               |.|..|::.                   :.|:|                ...|.:.|.....
Zfish   471 ---LATKRELVE-------------------REPSP----------------INMPGEERNVLME 497

  Fly   969 STATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGGDT 1033
            :...|.:...|.....|:|.||.|:..|||.| .|:..||.:.:.|:|....|:|||||||.|.|
Zfish   498 NGIDSHTFESISEDDSSLLHLKSSITSYFGAA-GRLTCGEKYQVLARRITPEGKVQYLVEWEGTT 561

Fly 1034 1033
Zfish 562 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	11/44 (25%)
		PHD_SF	426..469	CDD:304600	14/47 (30%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	24/50 (48%)
		Mtf2_C	985..1032	CDD:290768	22/46 (48%)
phf19	XP_005166909.1	TUDOR	38..85	CDD:197660	11/41 (27%)
		PHD_SF	96..146	CDD:304600	16/49 (33%)
		PHD2_PHF19	193..244	CDD:277056	24/50 (48%)
		Link_Domain	<233..349	CDD:295393	44/161 (27%)
		Mtf2_C	514..560	CDD:290768	22/46 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583822
Domainoid	1	1.000	47	1.000	Domainoid score	I12024
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12524
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3332
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm25418
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6663
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.020