DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and mtf2

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_001015829.2	Gene:	mtf2 / 550093	XenbaseID:	XB-GENE-1014957	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	719	Identity:	186/719 - (25%)
Similarity:	278/719 - (38%)	Gaps:	212/719 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 EDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTES 417
            :||..:.:||.||||||  |::......|.|:|.|:.|.....::.            ||..:|.
Frog    50 QDVLARWSDGLFYLGTIKKINKLRQSCFILFEDSSKSWVLWKDIQT------------GAIESEE 102

  Fly   418 TNTSPSGPMCVACKR--SDIEDVVEICERCGRGYHRGCTV-----EIVTGSGIWSCKRC------ 469
            .       :|..|:.  ||..:.:.||::||:|||:.|..     .::.....|.|::|
Frog   103 M-------VCSICQEEYSDAPNEIVICDKCGQGYHQLCHTPKIDPNVIETDEKWLCRQCVFASTT 160

  Fly   470 ---AKPMKMQQPVSHKITKPAGICRQLPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCC 531
               ..|.|.....:.::.|     :.|||:.:.|.||..|:.|.:|.|||||.||.:...|||||
Frog   161 KRGGAPKKGPNAKALQVMK-----QSLPYNLEDLEWDIGHKTNVQQCYCYCGGPGDWYLKMLQCC 220

  Fly   532 KCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKY 596
            ||:.|||..|:|..:|.:|.||.|:.|.|:|||:|.|:::|:.:.|||:.|:.||||.....:||
Frog   221 KCKQWFHEACVQCLEKPMLFGDRFYTFICSVCNSGPEYLKRLSLRWVDIAHLCLYNLSVIHKKKY 285

  Fly   597 HH-------LLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLKDYSDRFVCGREFKRAPA 654
            ..       .:||.|..|  |..:|      ...|.:...|.:...|.:....|:.|:|.|:...
Frog   286 FDSELELITYINDNWDRI--QPGEL------ADTPRSERYEHILDALNENKTMFMSGKEIKKKKH 342

  Fly   655 FYALRHSGPPHIPK--VFLEPHEELSDELL---EKRFKLMLMPEEPDEGANELPKRV----PKDV 710
            .:.||...||..|.  |.:|..|..|.|..   .|..|:..:.:|.:.|  |:.||.    |...
Frog   343 LFGLRIRVPPVPPNAAVKMEKEESTSHEFKIKGRKSSKVTPVTKEINNG--EVKKRKPVGRPPGS 405

  Fly   711 YEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIP 775
            :.....:::|.||                               |.||::...:      |....
Frog   406 HRRKILQNEPCET-------------------------------PSLANNMDTE------PVSEN 433

  Fly   776 PLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPP----VNFLGRNNPF 836
            .|||....|.||    .:..::|.::.||.:....|:...|||: :..|.|    |...||..|
Frog   434 SLLDTPEQRSRK----PEVTNSSSSNSDLETSGAVSAKETTSSI-VSSPQPDFRRVTRTGRTWP- 492

  Fly   837 LMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRR 901
             .:.|.:..:||                          .||      |.|...:..:..|.|.:
Frog   493 -ASIPPQKKRGR--------------------------LPR------RALQTHNSDLTKNDESK- 523

  Fly   902 RRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRNS 966
                                          :||||..           |.....|....|..:
Frog   524 ------------------------------EDLQPAG-----------LNTDIVKNLTEQDLQ-- 545

  Fly   967 TSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGG 1031
                               :..||.|:..|||.| .||..||.:.|.|:|...:|:|||||||.|
Frog   546 -------------------LNHLKNSITNYFGAA-GRIACGEKYRILARRVTLDGKVQYLVEWDG 590

  Fly  1032 DTAT 1035
            .||:
Frog   591 ATAS 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	16/45 (36%)
		PHD_SF	426..469	CDD:304600	14/49 (29%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	28/50 (56%)
		Mtf2_C	985..1032	CDD:290768	22/46 (48%)
mtf2	NP_001015829.2	TUDOR	45..95	CDD:197660	16/44 (36%)
		PHD1_MTF2	104..156	CDD:277053	15/51 (29%)
		PHD2_MTF2	203..254	CDD:277055	28/50 (56%)
		Mtf2_C	545..591	CDD:290768	22/67 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3313
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm48684
Panther	1	1.100	-	-	O	PTHR12628
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6663
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.180