DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and PHF1

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_077084.2	Gene:	PHF1 / 5252	HGNCID:	8919	Length:	567	Species:	Homo sapiens

Alignment Length:	737	Identity:	174/737 - (23%)
Similarity:	256/737 - (34%)	Gaps:	231/737 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 PPPPAPPVAAPSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSE---QWCEPD 394
            |..|| |.:.|.|.:...  :||..:..||..|||||  :|...:..|::|:|.|:   .|
Human    18 PASPA-PTSGPRPRLWEG--QDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLW---- 75

  Fly   395 KLRKLGGGSSITAGGGGASTTESTNTSPSG-P----MCVACKRSDIEDVVE-----ICERCGRGY 449
                                   .:.||:. |    :|..|:.   |.||.     .||:|...|
Human    76 -----------------------KDISPAALPGEELLCCVCRS---ETVVPGNRLVSCEKCRHAY 114

  Fly   450 HRGCTVEIVTGSG-----IWSCKRCAKPMKMQQ-------PVSHKITKPAGICRQLPYHADKLSW 502
            |:.|.|......|     .|.|::|...:..::       |.:..:   .|:...|||....|.|
Human   115 HQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAM---LGMKLSLPYGLKGLDW 176

  Fly   503 DEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGI 567
            |..|..|.:|.|||||.||:::..||||..|..|||..|.|...|.||.||.|:.|.|.||..|.
Human   177 DAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGP 241

  Fly   568 EFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMERL 632
            |.|||:|:.||||.|:.||:|.....:||.....:|.||..|....|.:.|...| |:.....||
Human   242 EKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDT-PKGERSSRL 305

  Fly   633 KQTLKDYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDE 697
            ...|..:.|||:.|||.|:....:.|....||                           |.||..
Human   306 LSALNSHKDRFISGREIKKRKCLFGLHARMPP---------------------------PVEPPT 343

  Fly   698 GANELPK---------RVPKDVYEFNTDEDDPVETSE----DEIPIKQIIEKAKKQAAQKADKHD 749
            |...|..         .|.:.:.:....|.:|:...:    :|:.....:....:...|:...|.
Human   344 GDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHL 408

  Fly   750 ELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSR 814
            :..|:..::.           |:|.|                                  :.|.:
Human   409 QRALQASVSP-----------PSPSP----------------------------------NQSYQ 428

  Fly   815 GTSSLDLIIPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMV 879
            |:|.        .||...:...|.::|.:.......|..|.              |||.:.....
Human   429 GSSG--------YNFRPTDARCLPSSPIRMFASFHPSASTA--------------GTSGDSGPPD 471

  Fly   880 RTIKRRLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKP 944
            |      |..::.||...::.:.....:|.:...:|:      ||..||
Human   472 R------SPLELHIGFPTDIPKSAPHSMTASSSSVSS------PSPGLP---------------- 508

  Fly   945 THGRLLRQRPQKQSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEP 1009
                              ||::..|....|.|.|.|..              ..|.:..:..|:|
Human   509 ------------------RRSAPPSPLCRSLSPGTGGG--------------VRGGVGYLSRGDP 541

  Fly  1010 FAIRAKRRMGNGQVQYLVEWGG 1031
            ..:.|:|...:|.|||||||||
Human   542 VRVLARRVRPDGSVQYLVEWGG 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	15/53 (28%)
		PHD_SF	426..469	CDD:304600	15/52 (29%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	27/50 (54%)
		Mtf2_C	985..1032	CDD:290768	15/47 (32%)
PHF1	NP_077084.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		6/13 (46%)
		Tudor_2	34..69	CDD:375553	13/36 (36%)
		PHD1_PHF1	89..139	CDD:276975	15/52 (29%)
		PHD2_PHF1	188..239	CDD:277057	27/50 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..441		22/187 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..537		23/155 (15%)
		Mtf2_C	<539..565	CDD:372898	14/25 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3343
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm41475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6663
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880